BMP4

GENERAL INFORMATION

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Gene name

BMP4

Gene description

Bone morphogenetic protein 4

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Smooth muscle expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Uncertain based on 2 antibodies.
HPA066235 , CAB006863
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

BMP4 (HGNC Symbol)

Synonyms

BMP2B

Description

Bone morphogenetic protein 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q22.2

Chromosome location (bp)

53949736 - 53958761

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125378 (version 78.38)

Entrez gene

652

UniProt

P12644 (UniProt - Evidence at protein level)

neXtProt

NX_P12644

Antibodypedia

BMP4 antibodies


PROTEIN BROWSER

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ENST00000245451
 
ENST00000417573
 
ENST00000558961
 
ENST00000558984
 
ENST00000559087
 
ENST00000559501
 
ENST00000559642
 
ENST00000609748
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BMP4-001 ENSP00000245451
ENST00000245451
P12644
Show all »
Show » Show » 408 46.6 Yes 0
BMP4-002 ENSP00000453485
ENST00000559087
P12644
Show all »
Show » Show » 408 46.6 Yes 0
BMP4-003 ENSP00000454134
ENST00000558984
P12644
Show all »
Show » Show » 408 46.6 Yes 0
BMP4-004 ENSP00000453467
ENST00000559642
H0YM53
Show all »
Show » Show » 110 12.3 Yes 0
BMP4-006 ENSP00000453365
ENST00000559501
H0YLW3
Show all »
Show » Show » 271 31.6 No 0
BMP4-007 ENSP00000453691
ENST00000558961
H0YMP9
Show all »
Show » Show » 104 11.9 No 0
BMP4-008 ENSP00000476690
ENST00000609748
V9GYF1
Show all »
Show » 29 3.4 No 0
BMP4-201 ENSP00000394165
ENST00000417573
P12644
Show all »
Show » Show » 408 46.6 Yes 0