AGO2

GENERAL INFORMATION

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Gene name

AGO2

Gene description

Argonaute RISC catalytic component 2

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB019309
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

AGO2 (HGNC Symbol)

Synonyms

EIF2C2, hAGO2, Q10

Description

Argonaute RISC catalytic component 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

8

Cytoband

q24.3

Chromosome location (bp)

140531165 - 140635619

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123908 (version 78.38)

Entrez gene

27161

UniProt

Q9UKV8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UKV8

Antibodypedia

AGO2 antibodies


PROTEIN BROWSER

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ENST00000220592
 
ENST00000519980
 
ENST00000524328
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AGO2-001 ENSP00000220592
ENST00000220592
Q9UKV8
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Show » Show » 859 97.2 No 0
AGO2-002 ENSP00000430176
ENST00000519980
Q9UKV8
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Show » Show » 825 93.6 No 0
AGO2-006 ENSP00000431056
ENST00000524328
E5RJY2
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Show » Show » 36 4.5 No 0