CDK2

GENERAL INFORMATION

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Gene name

CDK2

Gene description

Cyclin-dependent kinase 2

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

A fraction of cells in lymphoid tissues, squamous epithelia and gastrointestinal tract displayed strong nuclear staining, occasionally combined with positivity in the cytoplasm. Most other normal tissues were negative or displayed weak nuclear and cytoplasmic positivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB013115
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CDK2

Synonyms

Description

Cyclin-dependent kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

12

Cytoband

q13.2

Chromosome location (bp)

55966769 - 55972784

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123374 (version 78.38)

Entrez gene

1017

UniProt

P24941 (UniProt - Evidence at protein level)

neXtProt

NX_P24941

Antibodypedia

CDK2 antibodies


PROTEIN BROWSER

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ENST00000266970
 
ENST00000354056
 
ENST00000440311
 
ENST00000553376
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK2-001 ENSP00000266970
ENST00000266970
P24941
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Show » Show » 298 33.9 No 0
CDK2-002 ENSP00000243067
ENST00000354056
P24941
Show all »
Show » Show » 264 30 No 0
CDK2-003 ENSP00000393605
ENST00000440311
E7ESI2
Show all »
Show » Show » 238 27.2 No 0
CDK2-007 ENSP00000452514
ENST00000553376
G3V5T9
Show all »
Show » Show » 346 39.2 No 0