FKBP1B

GENERAL INFORMATION

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Gene name

FKBP1B

Gene description

FK506 binding protein 1B, 12.6 kDa

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed weak to moderate cytoplasmic positivity. Decidual cells and cells in renal tubules, parathyroid and fallopian tube showed strong cytoplasmic immunoreactivity. Remaining tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA051798
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

FKBP1B (HGNC Symbol)

Synonyms

FKBP12.6, FKBP1L, FKBP9, OTK4, PPIase

Description

FK506 binding protein 1B, 12.6 kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p23.3

Chromosome location (bp)

24049701 - 24063681

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119782 (version 78.38)

Entrez gene

2281

UniProt

P68106 (UniProt - Evidence at protein level)

neXtProt

NX_P68106

Antibodypedia

FKBP1B antibodies


PROTEIN BROWSER

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ENST00000380986
 
ENST00000380991
 
ENST00000452109
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FKBP1B-001 ENSP00000370373
ENST00000380986
P68106
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Show » Show » 108 11.8 No 0
FKBP1B-002 ENSP00000370379
ENST00000380991
P68106
Show all »
Show » Show » 80 8.8 No 0
FKBP1B-006 ENSP00000406593
ENST00000452109
F8W6G9
Show all »
Show » Show » 79 8.7 No 0