ABCD4

GENE INFORMATION

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Gene name

ABCD4 (HGNC Symbol)

Synonyms

EST352188, P70R, PMP69, PXMP1L

Description

ATP-binding cassette, sub-family D (ALD), member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q24.3

Chromosome location (bp)

74285423 - 74303056

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119688 (version 78.38)

Entrez gene

5826

UniProt

O14678 (UniProt - Evidence at protein level)

neXtProt

NX_O14678

Antibodypedia

ABCD4 antibodies
 

PROTEIN VIEW

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ABCD4-001
 
ABCD4-021
 
ABCD4-023
 
ABCD4-026
 
ABCD4-028
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCD4-001 ENSP00000349396
ENST00000356924
O14678
Show all »
Show » Show » 606 68.6 No 5
ABCD4-021 ENSP00000451770
ENST00000556971
Show » Show » 205 23.8 No 3
ABCD4-023 ENSP00000451993
ENST00000557588
G3V4U7
Show all »
Show » Show » 203 23.7 No 2
ABCD4-026 ENSP00000450960
ENST00000556517
Show » 184 19.9 No 0
ABCD4-028 ENSP00000450982
ENST00000555904
Show » Show » 158 17.9 No 0