Tissue expression of TRIM32 - Summary - The Human Protein Atlas

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TRIM32

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	TRIM32
Gene description	Tripartite motif containing 32
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed moderate to strong nuclear and occasional cytoplasmic positivity. Lung, spleen, hematopoietic cells, glial cells in hippocampus were in general negative.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 1 antibody. HPA050060
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Mixed

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	TRIM32 (HGNC Symbol)
Synonyms	BBS11, HT2A, LGMD2H, TATIP
Description	Tripartite motif containing 32 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q33.1
Chromosome location (bp)	116687302 - 116701300
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000119401 (version 78.38)
Entrez gene	22954
UniProt	Q13049 (UniProt - Evidence at protein level)
neXtProt	NX_Q13049
Antibodypedia	TRIM32 antibodies

PROTEIN BROWSER

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ENST00000373983		ENST00000411410		ENST00000450136

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
TRIM32-001	ENSP00000363095 ENST00000373983	Q13049 Show all » « Hide Q13049 [Direct mapping] E3 ubiquitin-protein ligase TRIM32 A0A024R843 [Target identity:100%; Query identity:100%] Tripartite motif-containing 32, isoform CRA_a {ECO:0000313\|EMBL:EAW87447.1} Q5JVY0 [Target identity:26%; Query identity:100%] E3 ubiquitin-protein ligase TRIM32 {ECO:0000313\|Ensembl:ENSP00000412603}	Show » « Hide Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000209 [protein polyubiquitination] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005863 [striated muscle myosin thick filament] GO:0008270 [zinc ion binding] GO:0009411 [response to UV] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0017022 [myosin binding] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0030957 [Tat protein binding] GO:0031369 [translation initiation factor binding] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032897 [negative regulation of viral transcription] GO:0034612 [response to tumor necrosis factor] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043621 [protein self-association] GO:0045087 [innate immune response] GO:0045444 [fat cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045732 [positive regulation of protein catabolic process] GO:0045787 [positive regulation of cell cycle] GO:0045862 [positive regulation of proteolysis] GO:0046872 [metal ion binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0050769 [positive regulation of neurogenesis] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:1902187 [negative regulation of viral release from host cell] GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:2000147 [positive regulation of cell motility]	653	72	No
TRIM32-002	ENSP00000412603 ENST00000411410	Q5JVY0 Show all » « Hide Q5JVY0 [Target identity:99%; Query identity:100%] E3 ubiquitin-protein ligase TRIM32 {ECO:0000313\|Ensembl:ENSP00000412603}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding]	173	19.3	No
TRIM32-201	ENSP00000408292 ENST00000450136	Q13049 Show all » « Hide Q13049 [Direct mapping] E3 ubiquitin-protein ligase TRIM32 A0A024R843 [Target identity:100%; Query identity:100%] Tripartite motif-containing 32, isoform CRA_a {ECO:0000313\|EMBL:EAW87447.1} Q5JVY0 [Target identity:26%; Query identity:100%] E3 ubiquitin-protein ligase TRIM32 {ECO:0000313\|Ensembl:ENSP00000412603}	Show » « Hide Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000209 [protein polyubiquitination] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005863 [striated muscle myosin thick filament] GO:0008270 [zinc ion binding] GO:0009411 [response to UV] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0017022 [myosin binding] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0030957 [Tat protein binding] GO:0031369 [translation initiation factor binding] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032897 [negative regulation of viral transcription] GO:0034612 [response to tumor necrosis factor] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043621 [protein self-association] GO:0045087 [innate immune response] GO:0045444 [fat cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045732 [positive regulation of protein catabolic process] GO:0045787 [positive regulation of cell cycle] GO:0045862 [positive regulation of proteolysis] GO:0046872 [metal ion binding] GO:0048147 [negative regulation of fibroblast proliferation] GO:0050769 [positive regulation of neurogenesis] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:1902187 [negative regulation of viral release from host cell] GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:2000147 [positive regulation of cell motility]	653	72	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx