TNFAIP3

GENERAL INFORMATION

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Gene name

TNFAIP3

Gene description

Tumor necrosis factor, alpha-induced protein 3

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

11
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Weak to moderate cytoplasmic immunoreactivity was observed in most normal tissues. Endothelial cells, plasma cells and macrophages were distinctly stained. Ovarian stroma and Purkinje cells showed strong positivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA002116
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

TNFAIP3 (HGNC Symbol)

Synonyms

A20, OTUD7C

Description

Tumor necrosis factor, alpha-induced protein 3 (HGNC Symbol)

Entrez gene summary

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

6

Cytoband

q23.3

Chromosome location (bp)

137867188 - 137883312

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118503 (version 78.38)

Entrez gene

7128

UniProt

P21580 (UniProt - Evidence at protein level)

neXtProt

NX_P21580

Antibodypedia

TNFAIP3 antibodies


PROTEIN BROWSER

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ENST00000237289
 
ENST00000420009
 
ENST00000421450
 
ENST00000433680
 
ENST00000612899
 
ENST00000614035
 
ENST00000614451
 
ENST00000615468
 
ENST00000619035
 
ENST00000620204
 
ENST00000621150
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFAIP3-001 ENSP00000237289
ENST00000237289
P21580
Show all »
Show » Show » 790 89.6 No 0
TNFAIP3-002 ENSP00000393577
ENST00000421450
Q5VXR0
Show all »
Show » 26 3 No 0
TNFAIP3-003 ENSP00000401562
ENST00000420009
Q5VXQ8
Show all »
Show » 162 19.2 No 0
TNFAIP3-004 ENSP00000409845
ENST00000433680
Q5VXQ9
Show all »
Show » 98 11.8 No 0
TNFAIP3-201 ENSP00000481570
ENST00000612899
P21580
Show all »
Show » Show » 790 89.6 No 0
TNFAIP3-202 ENSP00000481122
ENST00000614035
D3TTY9
Show all »
Show » Show » 470 54.3 No 0
TNFAIP3-203 ENSP00000481199
ENST00000614451
D3TTY7
Show all »
Show » 152 18 No 0
TNFAIP3-204 ENSP00000479556
ENST00000615468
D3TTZ6
Show all »
Show » 214 25.5 No 0
TNFAIP3-205 ENSP00000478438
ENST00000619035
D3TTZ2
Show all »
Show » Show » 749 84.9 No 0
TNFAIP3-206 ENSP00000481454
ENST00000620204
D3TTY5
Show all »
Show » Show » 669 76.2 No 0
TNFAIP3-207 ENSP00000484332
ENST00000621150
D3TTY6
Show all »
Show » Show » 531 61.1 No 0