APOA1 - Gene info - The Human Protein Atlas

Gene name

APOA1

Synonyms

Description

Apolipoprotein A-I (HGNC Symbol)

Entrez gene summary

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q23.3

Chromosome location (bp)

116835751 - 116837950

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118137 (version 78.38)

Entrez gene

335

UniProt

P02647 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOA1-001

ENSP00000236850
ENST00000236850

P02647
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P02647 [Direct mapping]
Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I
A0A024R3E3 [Target identity:100%; Query identity:100%]
Apolipoprotein A-I, isoform CRA_a {ECO:0000313|EMBL:EAW67276.1}

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001523 [retinoid metabolic process]
GO:0001540 [beta-amyloid binding]
GO:0001932 [regulation of protein phosphorylation]
GO:0001935 [endothelial cell proliferation]
GO:0002576 [platelet degranulation]
GO:0002740 [negative regulation of cytokine secretion involved in immune response]
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008203 [cholesterol metabolic process]
GO:0008211 [glucocorticoid metabolic process]
GO:0008289 [lipid binding]
GO:0009986 [cell surface]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0014012 [peripheral nervous system axon regeneration]
GO:0015485 [cholesterol binding]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0019899 [enzyme binding]
GO:0019915 [lipid storage]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0030301 [cholesterol transport]
GO:0030325 [adrenal gland development]
GO:0031100 [organ regeneration]
GO:0031410 [cytoplasmic vesicle]
GO:0031982 [vesicle]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034190 [apolipoprotein receptor binding]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034365 [discoidal high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034774 [secretory granule lumen]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042157 [lipoprotein metabolic process]
GO:0042158 [lipoprotein biosynthetic process]
GO:0042493 [response to drug]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043534 [blood vessel endothelial cell migration]
GO:0043627 [response to estrogen]
GO:0043691 [reverse cholesterol transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045499 [chemorepellent activity]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0050821 [protein stabilization]
GO:0050919 [negative chemotaxis]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051347 [positive regulation of transferase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0055102 [lipase inhibitor activity]
GO:0060192 [negative regulation of lipase activity]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060354 [negative regulation of cell adhesion molecule production]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070062 [extracellular vesicular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070508 [cholesterol import]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0071682 [endocytic vesicle lumen]
GO:0071813 [lipoprotein particle binding]
GO:0072562 [blood microparticle]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]

267

30.8

Yes

APOA1-002

ENSP00000364469
ENST00000375320

P02647
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GO:0001523 [retinoid metabolic process]
GO:0001540 [beta-amyloid binding]
GO:0002576 [platelet degranulation]
GO:0002740 [negative regulation of cytokine secretion involved in immune response]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006869 [lipid transport]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0015485 [cholesterol binding]
GO:0017127 [cholesterol transporter activity]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030168 [platelet activation]
GO:0030301 [cholesterol transport]
GO:0031410 [cytoplasmic vesicle]
GO:0031982 [vesicle]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034190 [apolipoprotein receptor binding]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034774 [secretory granule lumen]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043691 [reverse cholesterol transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045499 [chemorepellent activity]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0050821 [protein stabilization]
GO:0050919 [negative chemotaxis]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060354 [negative regulation of cell adhesion molecule production]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070062 [extracellular vesicular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070508 [cholesterol import]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]

267

30.8

Yes

APOA1-003

ENSP00000364472
ENST00000375323

P02647
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267

30.8

Yes

APOA1-004

ENSP00000352471
ENST00000359492

P02647
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267

30.8

Yes

APOA1-005

ENSP00000364478
ENST00000375329

F8W696
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F8W696 [Target identity:100%; Query identity:100%]
Truncated apolipoprotein A-I {ECO:0000313|Ensembl:ENSP00000364478}

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SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]

245

27.9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.