Tissue expression of EPHA4 - Summary - The Human Protein Atlas

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EPHA4

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	EPHA4
Gene description	EPH receptor A4
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Mixed
GTEx:	Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several different tissue types, highly abundant in brain.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Data reliability	Supportive based on 1 antibody. CAB028368
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Mixed

Organ

Expression

GTEx dataset

RNA tissue category:

Mixed

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	EPHA4 (HGNC Symbol)
Synonyms	Hek8, TYRO1
Description	EPH receptor A4 (HGNC Symbol)
Entrez gene summary	This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q36.1
Chromosome location (bp)	221418027 - 221574202
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116106 (version 78.38)
Entrez gene	2043
UniProt	P54764 (UniProt - Evidence at protein level)
neXtProt	NX_P54764
Antibodypedia	EPHA4 antibodies

PROTEIN BROWSER

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ENST00000281821		ENST00000409854		ENST00000409938		ENST00000419964		ENST00000434266		ENST00000441679		ENST00000443796		ENST00000541600

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
EPHA4-001	ENSP00000386829 ENST00000409938	P54764 Show all » « Hide P54764 [Direct mapping] Ephrin type-A receptor 4 A0A024R452 [Target identity:100%; Query identity:100%] EPH receptor A4, isoform CRA_a {ECO:0000313\|EMBL:EAW70786.1} E9PG71 [Target identity:96%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000386276} Q53TA0 [Target identity:72%; Query identity:100%] Putative uncharacterized protein EPHA4 {ECO:0000313\|EMBL:AAY24284.1} Q584H6 [Target identity:27%; Query identity:100%] Putative uncharacterized protein EPHA4 {ECO:0000313\|EMBL:AAX81994.1} F5GZZ5 [Target identity:15%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000444085} C9JEM6 [Target identity:12%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000410158} C9JIX8 [Target identity:9%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000404089}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005004 [GPI-linked ephrin receptor activity] GO:0005005 [transmembrane-ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008045 [motor neuron axon guidance] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0021957 [corticospinal tract morphogenesis] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031901 [early endosome membrane] GO:0032314 [regulation of Rac GTPase activity] GO:0032317 [regulation of Rap GTPase activity] GO:0042731 [PH domain binding] GO:0045211 [postsynaptic membrane] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048681 [negative regulation of axon regeneration] GO:0048710 [regulation of astrocyte differentiation] GO:0050770 [regulation of axonogenesis] GO:0061001 [regulation of dendritic spine morphogenesis] GO:0097155 [fasciculation of sensory neuron axon] GO:0097156 [fasciculation of motor neuron axon] GO:0097161 [DH domain binding] GO:2001108 [positive regulation of Rho guanyl-nucleotide exchange factor activity]	986	109.9	Yes	2
EPHA4-002	ENSP00000444085 ENST00000541600	F5GZZ5 Show all » « Hide F5GZZ5 [Target identity:100%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000444085} C9JIX8 [Target identity:61%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000404089}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0048013 [ephrin receptor signaling pathway]	149	17.2	Yes	0
EPHA4-003	ENSP00000386276 ENST00000409854	E9PG71 Show all » « Hide E9PG71 [Target identity:100%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000386276} Q584H6 [Target identity:28%; Query identity:100%] Putative uncharacterized protein EPHA4 {ECO:0000313\|EMBL:AAX81994.1} F5GZZ5 [Target identity:15%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000444085} C9JEM6 [Target identity:13%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000410158} C9JIX8 [Target identity:9%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000404089}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0048013 [ephrin receptor signaling pathway]	949	105.7	Yes	2
EPHA4-004	ENSP00000404089 ENST00000434266	C9JIX8 Show all » « Hide C9JIX8 [Target identity:100%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000404089}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0048013 [ephrin receptor signaling pathway]	91	10.3	Yes	0
EPHA4-005	ENSP00000410158 ENST00000419964	C9JEM6 Show all » « Hide C9JEM6 [Target identity:100%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000410158}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0048013 [ephrin receptor signaling pathway]	126	14.9	No	0
EPHA4-006	ENSP00000401405 ENST00000441679		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	189	20.1	No	0
EPHA4-012	ENSP00000395917 ENST00000443796	C9JFX5 Show all » « Hide C9JFX5 [Target identity:100%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000395917}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	177	19	Yes	0
EPHA4-201	ENSP00000281821 ENST00000281821	P54764 Show all » « Hide P54764 [Direct mapping] Ephrin type-A receptor 4 A0A024R452 [Target identity:100%; Query identity:100%] EPH receptor A4, isoform CRA_a {ECO:0000313\|EMBL:EAW70786.1} E9PG71 [Target identity:96%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000386276} Q53TA0 [Target identity:72%; Query identity:100%] Putative uncharacterized protein EPHA4 {ECO:0000313\|EMBL:AAY24284.1} Q584H6 [Target identity:27%; Query identity:100%] Putative uncharacterized protein EPHA4 {ECO:0000313\|EMBL:AAX81994.1} F5GZZ5 [Target identity:15%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000444085} C9JEM6 [Target identity:12%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000410158} C9JIX8 [Target identity:9%; Query identity:100%] Ephrin type-A receptor 4 {ECO:0000313\|Ensembl:ENSP00000404089}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005003 [ephrin receptor activity] GO:0005004 [GPI-linked ephrin receptor activity] GO:0005005 [transmembrane-ephrin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008045 [motor neuron axon guidance] GO:0008347 [glial cell migration] GO:0009986 [cell surface] GO:0014069 [postsynaptic density] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0021957 [corticospinal tract morphogenesis] GO:0030054 [cell junction] GO:0030175 [filopodium] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031594 [neuromuscular junction] GO:0031901 [early endosome membrane] GO:0032314 [regulation of Rac GTPase activity] GO:0032317 [regulation of Rap GTPase activity] GO:0032319 [regulation of Rho GTPase activity] GO:0042731 [PH domain binding] GO:0042802 [identical protein binding] GO:0042995 [cell projection] GO:0043197 [dendritic spine] GO:0043204 [perikaryon] GO:0043507 [positive regulation of JUN kinase activity] GO:0043679 [axon terminus] GO:0044295 [axonal growth cone] GO:0044297 [cell body] GO:0045211 [postsynaptic membrane] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048013 [ephrin receptor signaling pathway] GO:0048681 [negative regulation of axon regeneration] GO:0048710 [regulation of astrocyte differentiation] GO:0050770 [regulation of axonogenesis] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0061001 [regulation of dendritic spine morphogenesis] GO:0097155 [fasciculation of sensory neuron axon] GO:0097156 [fasciculation of motor neuron axon] GO:0097161 [DH domain binding] GO:2001108 [positive regulation of Rho guanyl-nucleotide exchange factor activity]	986	109.9	Yes	2

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx