ATF2

GENERAL INFORMATION

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Gene name

ATF2

Gene description

Activating transcription factor 2

Protein class

Enzymes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

11
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA022134 , CAB003769
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ATF2 (HGNC Symbol)

Synonyms

CRE-BP1, CREB2, HB16, TREB7

Description

Activating transcription factor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

Chromosome

2

Cytoband

q31.1

Chromosome location (bp)

175072250 - 175168382

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115966 (version 78.38)

Entrez gene

1386

UniProt

P15336 (UniProt - Evidence at protein level)

neXtProt

NX_P15336

Antibodypedia

ATF2 antibodies


PROTEIN BROWSER

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ENST00000264110
 
ENST00000345739
 
ENST00000392544
 
ENST00000409437
 
ENST00000409499
 
ENST00000409635
 
ENST00000409833
 
ENST00000426833
 
ENST00000435004
 
ENST00000437522
 
ENST00000538946
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATF2-001 ENSP00000264110
ENST00000264110
P15336
Show all »
Show » Show » 505 54.5 No 0
ATF2-002 ENSP00000376327
ENST00000392544
P15336
Show all »
Show » Show » 505 54.5 No 0
ATF2-009 ENSP00000386526
ENST00000409833
P15336
Show all »
Show » Show » 209 23 No 0
ATF2-011 ENSP00000386326
ENST00000409437
B8ZZU6
Show all »
Show » Show » 389 42.3 No 0
ATF2-012 ENSP00000387093
ENST00000409635
P15336
Show all »
Show » Show » 447 48 No 0
ATF2-013 ENSP00000340576
ENST00000345739
P15336
Show all »
Show » Show » 447 48 No 0
ATF2-014 ENSP00000386282
ENST00000409499
P15336
Show all »
Show » Show » 144 15.4 No 0
ATF2-015 ENSP00000416854
ENST00000437522
C9JCI8
Show all »
Show » 189 20.3 No 0
ATF2-021 ENSP00000406995
ENST00000435004
Show » Show » 265 30 No 0
ATF2-201 ENSP00000407911
ENST00000426833
P15336
Show all »
Show » Show » 487 52.3 No 0
ATF2-202 ENSP00000437952
ENST00000538946
Show » Show » 329 35 No 0