GCG

GENE INFORMATION

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Gene name

GCG (HGNC Symbol)

Synonyms

GLP1, GLP2, GRPP

Description

Glucagon (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q24.2

Chromosome location (bp)

162142873 - 162152404

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115263 (version 78.38)

Entrez gene

2641

UniProt

P01275 (UniProt - Evidence at protein level)

neXtProt

NX_P01275

Antibodypedia

GCG antibodies
 

PROTEIN VIEW

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GCG-001
 
GCG-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GCG-001 ENSP00000387662
ENST00000418842
P01275
Show all »
Show » Show » 180 20.9 Yes 0
GCG-201 ENSP00000364647
ENST00000375497
P01275
Show all »
Show » Show » 180 20.9 Yes 0