Tissue expression of CD86 - Summary - The Human Protein Atlas

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CD86

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	CD86
Gene description	CD86 molecule
Protein class	CD markers FDA approved drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate cytoplasmic positivity. Stromal cells, glial cells and myocytes were generally negative.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 1 antibody. CAB004319
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Mixed

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enhanced (spleen)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CD86 (HGNC Symbol)
Synonyms	B7-2, B7.2, CD28LG2
Description	CD86 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Chromosome	3
Cytoband	q13.33
Chromosome location (bp)	122055366 - 122121139
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114013 (version 78.38)
Entrez gene	942
UniProt	P42081 (UniProt - Evidence at protein level)
neXtProt	NX_P42081
Antibodypedia	CD86 antibodies

PROTEIN BROWSER

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ENST00000264468		ENST00000330540		ENST00000393627		ENST00000469710		ENST00000478741		ENST00000482356		ENST00000493101

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CD86-001	ENSP00000332049 ENST00000330540	P42081 Show all » « Hide P42081 [Direct mapping] T-lymphocyte activation antigen CD86 C9JXS1 [Target identity:50%; Query identity:100%] T-lymphocyte activation antigen CD86 {ECO:0000313\|Ensembl:ENSP00000419116}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001878 [response to yeast] GO:0002224 [toll-like receptor signaling pathway] GO:0002309 [T cell proliferation involved in immune response] GO:0002668 [negative regulation of T cell anergy] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031295 [T cell costimulation] GO:0032496 [response to lipopolysaccharide] GO:0034341 [response to interferon-gamma] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042102 [positive regulation of T cell proliferation] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0042493 [response to drug] GO:0043011 [myeloid dendritic cell differentiation] GO:0043017 [positive regulation of lymphotoxin A biosynthetic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051607 [defense response to virus] GO:0070062 [extracellular vesicular exosome] GO:0071222 [cellular response to lipopolysaccharide] GO:0071248 [cellular response to metal ion] GO:0071345 [cellular response to cytokine stimulus]	329	37.7	Yes	1
CD86-002	ENSP00000377248 ENST00000393627	P42081 Show all » « Hide P42081 [Direct mapping] T-lymphocyte activation antigen CD86 C9JXS1 [Target identity:51%; Query identity:100%] T-lymphocyte activation antigen CD86 {ECO:0000313\|Ensembl:ENSP00000419116}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031295 [T cell costimulation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042110 [T cell activation] GO:0043017 [positive regulation of lymphotoxin A biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0070062 [extracellular vesicular exosome]	323	37	Yes	1
CD86-003	ENSP00000418988 ENST00000469710	P42081 Show all » « Hide P42081 [Direct mapping] T-lymphocyte activation antigen CD86	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031295 [T cell costimulation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042110 [T cell activation] GO:0043017 [positive regulation of lymphotoxin A biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0070062 [extracellular vesicular exosome]	247	28.4	No	1
CD86-004	ENSP00000420230 ENST00000493101	P42081 Show all » « Hide P42081 [Direct mapping] T-lymphocyte activation antigen CD86	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031295 [T cell costimulation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042110 [T cell activation] GO:0043017 [positive regulation of lymphotoxin A biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0070062 [extracellular vesicular exosome]	217	24.8	Yes	1
CD86-005	ENSP00000417195 ENST00000478741	C9JXS1 Show all » « Hide C9JXS1 [Target identity:60%; Query identity:100%] T-lymphocyte activation antigen CD86 {ECO:0000313\|Ensembl:ENSP00000419116}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	277	31.4	Yes	0
CD86-007	ENSP00000419116 ENST00000482356	C9JXS1 Show all » « Hide C9JXS1 [Target identity:100%; Query identity:100%] T-lymphocyte activation antigen CD86 {ECO:0000313\|Ensembl:ENSP00000419116}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	167	19	Yes	0
CD86-201	ENSP00000264468 ENST00000264468	P42081 Show all » « Hide P42081 [Direct mapping] T-lymphocyte activation antigen CD86 C9JXS1 [Target identity:60%; Query identity:100%] T-lymphocyte activation antigen CD86 {ECO:0000313\|Ensembl:ENSP00000419116}	Show » « Hide CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031295 [T cell costimulation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042110 [T cell activation] GO:0043017 [positive regulation of lymphotoxin A biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0070062 [extracellular vesicular exosome]	275	31.3	Yes	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx