BCL6

GENERAL INFORMATION

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Gene name

BCL6

Gene description

B-cell CLL/lymphoma 6

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression, mainly in lymphoid tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA004899 , CAB000307
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

BCL6 (HGNC Symbol)

Synonyms

BCL5, BCL6A, LAZ3, ZBTB27, ZNF51

Description

B-cell CLL/lymphoma 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

3

Cytoband

q27.3

Chromosome location (bp)

187721377 - 187745727

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113916 (version 78.38)

Entrez gene

604

UniProt

P41182 (UniProt - Evidence at protein level)

neXtProt

NX_P41182

Antibodypedia

BCL6 antibodies


PROTEIN BROWSER

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ENST00000232014
 
ENST00000406870
 
ENST00000430339
 
ENST00000438077
 
ENST00000450123
 
ENST00000621333
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL6-001 ENSP00000384371
ENST00000406870
P41182
Show all »
Show » Show » 706 78.8 No 0
BCL6-004 ENSP00000232014
ENST00000232014
P41182
Show all »
Show » Show » 706 78.8 No 0
BCL6-007 ENSP00000414455
ENST00000438077
C9JL16
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Show » Show » 104 11.8 No 0
BCL6-008 ENSP00000415574
ENST00000430339
C9JCS5
Show all »
Show » Show » 122 13.9 No 0
BCL6-010 ENSP00000413122
ENST00000450123
P41182
Show all »
Show » Show » 650 72.4 No 0
BCL6-201 ENSP00000479784
ENST00000621333
P41182
Show all »
Show » Show » 650 72.4 No 0