FGF1 - Gene info - The Human Protein Atlas

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FGF1

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TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	FGF1 (HGNC Symbol)
Synonyms	AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, HBGF1
Description	Fibroblast growth factor 1 (acidic) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	142592178 - 142698070
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113578 (version 78.38)
Entrez gene	2246
UniProt	P05230 (UniProt - Evidence at protein level)
neXtProt	NX_P05230
Antibodypedia	FGF1 antibodies

PROTEIN VIEW

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FGF1-001		FGF1-002		FGF1-004		FGF1-006		FGF1-007		FGF1-008		FGF1-009		FGF1-010		FGF1-013		FGF1-201		FGF1-202		FGF1-203		FGF1-204

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
FGF1-001	ENSP00000352329 ENST00000359370	P05230 Show all » « Hide P05230 [Direct mapping] Fibroblast growth factor 1 A8K147 [Target identity:99%; Query identity:100%] Fibroblast growth factor {ECO:0000256\|RuleBase:RU049442} Q6LBM3 [Target identity:41%; Query identity:100%] Fibroblast growth factor {ECO:0000313\|EMBL:CAA41788.1} Q9UBK1 [Target identity:38%; Query identity:100%] Acidic fibroblast growth factor {ECO:0000313\|EMBL:AAA52447.1} C9JDC5 [Target identity:37%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000378005} C9JUP6 [Target identity:26%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction]	155	17.5	No	0
FGF1-002	ENSP00000338548 ENST00000337706	P05230 Show all » « Hide P05230 [Direct mapping] Fibroblast growth factor 1 A8K147 [Target identity:99%; Query identity:100%] Fibroblast growth factor {ECO:0000256\|RuleBase:RU049442} Q6LBM3 [Target identity:41%; Query identity:100%] Fibroblast growth factor {ECO:0000313\|EMBL:CAA41788.1} Q9UBK1 [Target identity:38%; Query identity:100%] Acidic fibroblast growth factor {ECO:0000313\|EMBL:AAA52447.1} C9JDC5 [Target identity:37%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000378005} C9JUP6 [Target identity:26%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction]	155	17.5	No	0
FGF1-004	ENSP00000378005 ENST00000394496	C9JDC5 Show all » « Hide C9JDC5 [Target identity:100%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000378005} C9JUP6 [Target identity:70%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005104 [fibroblast growth factor receptor binding] GO:0005634 [nucleus] GO:0008543 [fibroblast growth factor receptor signaling pathway]	58	6.5	No	0
FGF1-006	ENSP00000404742 ENST00000441680	P05230 Show all » « Hide P05230 [Direct mapping] Fibroblast growth factor 1 A8K147 [Target identity:99%; Query identity:100%] Fibroblast growth factor {ECO:0000256\|RuleBase:RU049442} Q6LBM3 [Target identity:41%; Query identity:100%] Fibroblast growth factor {ECO:0000313\|EMBL:CAA41788.1} Q9UBK1 [Target identity:38%; Query identity:100%] Acidic fibroblast growth factor {ECO:0000313\|EMBL:AAA52447.1} C9JDC5 [Target identity:37%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000378005} C9JUP6 [Target identity:26%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction]	155	17.5	No	0
FGF1-007	ENSP00000354231 ENST00000360966	P05230 Show all » « Hide P05230 [Direct mapping] Fibroblast growth factor 1 C9JUP6 [Target identity:68%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction]	60	6.7	No	0
FGF1-008	ENSP00000367285 ENST00000378046	P05230 Show all » « Hide P05230 [Direct mapping] Fibroblast growth factor 1 A8K147 [Target identity:99%; Query identity:100%] Fibroblast growth factor {ECO:0000256\|RuleBase:RU049442} Q6LBM3 [Target identity:41%; Query identity:100%] Fibroblast growth factor {ECO:0000313\|EMBL:CAA41788.1} Q9UBK1 [Target identity:38%; Query identity:100%] Acidic fibroblast growth factor {ECO:0000313\|EMBL:AAA52447.1} C9JDC5 [Target identity:37%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000378005} C9JUP6 [Target identity:26%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction]	155	17.5	No	0
FGF1-009	ENSP00000383969 ENST00000407758	B5MCF4 Show all » « Hide B5MCF4 [Target identity:100%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000383969} C9JUP6 [Target identity:44%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005104 [fibroblast growth factor receptor binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0008083 [growth factor activity] GO:0008543 [fibroblast growth factor receptor signaling pathway]	93	10.4	No	0
FGF1-010	ENSP00000396195 ENST00000419524	P05230 Show all » « Hide P05230 [Direct mapping] Fibroblast growth factor 1 A8K147 [Target identity:99%; Query identity:100%] Fibroblast growth factor {ECO:0000256\|RuleBase:RU049442} Q6LBM3 [Target identity:41%; Query identity:100%] Fibroblast growth factor {ECO:0000313\|EMBL:CAA41788.1} Q9UBK1 [Target identity:38%; Query identity:100%] Acidic fibroblast growth factor {ECO:0000313\|EMBL:AAA52447.1} C9JDC5 [Target identity:37%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000378005} C9JUP6 [Target identity:26%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction]	155	17.5	No	0
FGF1-013	ENSP00000399458 ENST00000411960	C9JUP6 Show all » « Hide C9JUP6 [Target identity:100%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005104 [fibroblast growth factor receptor binding] GO:0008543 [fibroblast growth factor receptor signaling pathway]	41	4.6	No	0
FGF1-201	ENSP00000481868 ENST00000610990	P05230 Show all » « Hide P05230 [Direct mapping] Fibroblast growth factor 1 A8K147 [Target identity:99%; Query identity:100%] Fibroblast growth factor {ECO:0000256\|RuleBase:RU049442} Q6LBM3 [Target identity:41%; Query identity:100%] Fibroblast growth factor {ECO:0000313\|EMBL:CAA41788.1} Q9UBK1 [Target identity:38%; Query identity:100%] Acidic fibroblast growth factor {ECO:0000313\|EMBL:AAA52447.1} C9JDC5 [Target identity:37%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000378005} C9JUP6 [Target identity:26%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction]	155	17.5	No	0
FGF1-202	ENSP00000479024 ENST00000612258	P05230 Show all » « Hide P05230 [Direct mapping] Fibroblast growth factor 1 A8K147 [Target identity:99%; Query identity:100%] Fibroblast growth factor {ECO:0000256\|RuleBase:RU049442} Q6LBM3 [Target identity:41%; Query identity:100%] Fibroblast growth factor {ECO:0000313\|EMBL:CAA41788.1} Q9UBK1 [Target identity:38%; Query identity:100%] Acidic fibroblast growth factor {ECO:0000313\|EMBL:AAA52447.1} C9JDC5 [Target identity:37%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000378005} C9JUP6 [Target identity:26%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction]	155	17.5	No	0
FGF1-203	ENSP00000480980 ENST00000619447	P05230 Show all » « Hide P05230 [Direct mapping] Fibroblast growth factor 1 A8K147 [Target identity:99%; Query identity:100%] Fibroblast growth factor {ECO:0000256\|RuleBase:RU049442} Q6LBM3 [Target identity:41%; Query identity:100%] Fibroblast growth factor {ECO:0000313\|EMBL:CAA41788.1} Q9UBK1 [Target identity:38%; Query identity:100%] Acidic fibroblast growth factor {ECO:0000313\|EMBL:AAA52447.1} C9JDC5 [Target identity:37%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000378005} C9JUP6 [Target identity:26%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction]	155	17.5	No	0
FGF1-204	ENSP00000480791 ENST00000621536	P05230 Show all » « Hide P05230 [Direct mapping] Fibroblast growth factor 1 A8K147 [Target identity:99%; Query identity:100%] Fibroblast growth factor {ECO:0000256\|RuleBase:RU049442} Q6LBM3 [Target identity:41%; Query identity:100%] Fibroblast growth factor {ECO:0000313\|EMBL:CAA41788.1} Q9UBK1 [Target identity:38%; Query identity:100%] Acidic fibroblast growth factor {ECO:0000313\|EMBL:AAA52447.1} C9JDC5 [Target identity:37%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000378005} C9JUP6 [Target identity:26%; Query identity:100%] Fibroblast growth factor 1 {ECO:0000313\|Ensembl:ENSP00000399458}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0001759 [organ induction] GO:0001934 [positive regulation of protein phosphorylation] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030154 [cell differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030544 [Hsp70 protein binding] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction]	155	17.5	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.