TBP - Gene info - The Human Protein Atlas

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TBP

TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	TBP (HGNC Symbol)
Synonyms	GTF2D1, SCA17, TFIID
Description	TATA box binding protein (HGNC Symbol)
Entrez gene summary	Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	170554302 - 170572870
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112592 (version 78.38)
Entrez gene	6908
UniProt	P20226 (UniProt - Evidence at protein level)
neXtProt	NX_P20226
Antibodypedia	TBP antibodies

PROTEIN VIEW

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TBP-001		TBP-002		TBP-003		TBP-004		TBP-201		TBP-202		TBP-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
TBP-001	ENSP00000230354 ENST00000230354	P20226 Show all » « Hide P20226 [Direct mapping] TATA-box-binding protein Q32MN7 [Target identity:99%; Query identity:100%] TATA box binding protein {ECO:0000313\|EMBL:AAI09054.1}; TATA box binding protein, isoform CRA_a {ECO:0000313\|EMBL:EAW47418.1} B4DPC1 [Target identity:93%; Query identity:100%] cDNA FLJ51920, highly similar to TATA-box-binding protein {ECO:0000313\|EMBL:BAG60533.1} Q7Z6S5 [Target identity:61%; Query identity:100%] TATA-box-binding protein {ECO:0000313\|Ensembl:ENSP00000400008} C0LUL1 [Target identity:48%; Query identity:100%] TATA-box binding protein N-terminal domain splice variant {ECO:0000313\|EMBL:ACN86311.1} Q7Z6S4 [Target identity:44%; Query identity:100%] TATA-box-binding protein {ECO:0000313\|Ensembl:ENSP00000416482} D2CT63 [Target identity:34%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04969.1} D2CT64 [Target identity:33%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04970.1} D2CT65 [Target identity:33%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04971.1} D2CT66 [Target identity:33%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04972.1}	Show » « Hide Predicted intracellular proteins Transcription factors beta-Sheet binding to DNA Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0005672 [transcription factor TFIIA complex] GO:0005719 [nuclear euchromatin] GO:0006352 [DNA-templated transcription, initiation] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006361 [transcription initiation from RNA polymerase I promoter] GO:0006362 [transcription elongation from RNA polymerase I promoter] GO:0006363 [termination of RNA polymerase I transcription] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] GO:0008134 [transcription factor binding] GO:0008219 [cell death] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0044212 [transcription regulatory region DNA binding] GO:0070491 [repressing transcription factor binding]	339	37.7	No	0
TBP-002	ENSP00000404905 ENST00000446829		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0006352 [DNA-templated transcription, initiation]	101	11.5	No	0
TBP-003	ENSP00000416482 ENST00000423353	Q7Z6S4 Show all » « Hide Q7Z6S4 [Target identity:99%; Query identity:100%] TATA-box-binding protein {ECO:0000313\|Ensembl:ENSP00000416482} D2CT63 [Target identity:76%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04969.1} D2CT66 [Target identity:76%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04972.1} D2CT64 [Target identity:74%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04970.1} D2CT65 [Target identity:74%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04971.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0006352 [DNA-templated transcription, initiation]	151	16.7	No	0
TBP-004	ENSP00000400008 ENST00000421512	Q7Z6S5 Show all » « Hide Q7Z6S5 [Target identity:100%; Query identity:100%] TATA-box-binding protein {ECO:0000313\|Ensembl:ENSP00000400008} C0LUL1 [Target identity:79%; Query identity:100%] TATA-box binding protein N-terminal domain splice variant {ECO:0000313\|EMBL:ACN86311.1} Q7Z6S4 [Target identity:72%; Query identity:100%] TATA-box-binding protein {ECO:0000313\|Ensembl:ENSP00000416482} D2CT63 [Target identity:55%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04969.1} D2CT66 [Target identity:55%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04972.1} D2CT64 [Target identity:54%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04970.1} D2CT65 [Target identity:53%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04971.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0006352 [DNA-templated transcription, initiation]	208	22.9	No	0
TBP-201	ENSP00000375942 ENST00000392092	P20226 Show all » « Hide P20226 [Direct mapping] TATA-box-binding protein Q32MN7 [Target identity:99%; Query identity:100%] TATA box binding protein {ECO:0000313\|EMBL:AAI09054.1}; TATA box binding protein, isoform CRA_a {ECO:0000313\|EMBL:EAW47418.1} B4DPC1 [Target identity:93%; Query identity:100%] cDNA FLJ51920, highly similar to TATA-box-binding protein {ECO:0000313\|EMBL:BAG60533.1} Q7Z6S5 [Target identity:61%; Query identity:100%] TATA-box-binding protein {ECO:0000313\|Ensembl:ENSP00000400008} C0LUL1 [Target identity:48%; Query identity:100%] TATA-box binding protein N-terminal domain splice variant {ECO:0000313\|EMBL:ACN86311.1} Q7Z6S4 [Target identity:44%; Query identity:100%] TATA-box-binding protein {ECO:0000313\|Ensembl:ENSP00000416482} D2CT63 [Target identity:34%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04969.1} D2CT64 [Target identity:33%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04970.1} D2CT65 [Target identity:33%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04971.1} D2CT66 [Target identity:33%; Query identity:100%] TATA-box binding protein {ECO:0000313\|EMBL:ACJ04972.1}	Show » « Hide Predicted intracellular proteins Transcription factors beta-Sheet binding to DNA Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001939 [female pronucleus] GO:0001940 [male pronucleus] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0005672 [transcription factor TFIIA complex] GO:0005719 [nuclear euchromatin] GO:0005737 [cytoplasm] GO:0006352 [DNA-templated transcription, initiation] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006361 [transcription initiation from RNA polymerase I promoter] GO:0006362 [transcription elongation from RNA polymerase I promoter] GO:0006363 [termination of RNA polymerase I transcription] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] GO:0007283 [spermatogenesis] GO:0008134 [transcription factor binding] GO:0008219 [cell death] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0044212 [transcription regulatory region DNA binding] GO:0045120 [pronucleus] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0070491 [repressing transcription factor binding]	339	37.7	No	0
TBP-202	ENSP00000442132 ENST00000540980	P20226 Show all » « Hide P20226 [Direct mapping] TATA-box-binding protein	Show » « Hide Predicted intracellular proteins Transcription factors beta-Sheet binding to DNA Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0005672 [transcription factor TFIIA complex] GO:0005719 [nuclear euchromatin] GO:0006352 [DNA-templated transcription, initiation] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006361 [transcription initiation from RNA polymerase I promoter] GO:0006362 [transcription elongation from RNA polymerase I promoter] GO:0006363 [termination of RNA polymerase I transcription] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] GO:0008134 [transcription factor binding] GO:0008219 [cell death] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0044212 [transcription regulatory region DNA binding] GO:0070491 [repressing transcription factor binding]	319	35.7	No	0
TBP-203	ENSP00000484118 ENST00000616883	Q32MN6 Show all » « Hide Q32MN6 [Target identity:100%; Query identity:100%] TBP protein {ECO:0000313\|EMBL:AAI09055.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0006352 [DNA-templated transcription, initiation]	288	31.6	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.