TRPV4

GENERAL INFORMATION

? »

Gene name

TRPV4

Gene description

Transient receptor potential cation channel, subfamily V, member 4

Protein class

Disease related genes
Potential drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enhanced (kidney, salivary gland)
GTEx:Tissue enhanced (salivary gland)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous expression in several tissues.

ANTIBODY RELIABILITY

? »

Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA007150
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enhanced (kidney, salivary gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (salivary gland)

Organ

Expression



GENE INFORMATION

? »

Gene name

TRPV4 (HGNC Symbol)

Synonyms

CMT2C, OTRPC4, TRP12, VR-OAC, VRL-2, VROAC

Description

Transient receptor potential cation channel, subfamily V, member 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Chromosome

12

Cytoband

q24.11

Chromosome location (bp)

109783085 - 109833401

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111199 (version 78.38)

Entrez gene

59341

UniProt

Q9HBA0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HBA0

Antibodypedia

TRPV4 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000261740
 
ENST00000418703
 
ENST00000536838
 
ENST00000537083
 
ENST00000541794
 
ENST00000544971
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRPV4-001 ENSP00000261740
ENST00000261740
Q9HBA0
Show all »
Show » Show » 871 98.3 No 6
TRPV4-002 ENSP00000443611
ENST00000544971
Q9HBA0
Show all »
Show » Show » 764 85.9 No 6
TRPV4-003 ENSP00000442738
ENST00000537083
Q9HBA0
Show all »
Show » Show » 811 91.3 No 6
TRPV4-004 ENSP00000442167
ENST00000541794
Q9HBA0
Show all »
Show » Show » 824 92.9 No 6
TRPV4-005 ENSP00000444336
ENST00000536838
Q9HBA0
Show all »
Show » Show » 837 95 No 6
TRPV4-006 ENSP00000406191
ENST00000418703
Q9HBA0
Show all »
Show » Show » 871 98.3 No 6