Tissue expression of SLC11A2 - Summary - The Human Protein Atlas

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SLC11A2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	SLC11A2
Gene description	Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous expression at variable levels in several different cell types.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 2 antibodies. HPA032139 , HPA032140
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	SLC11A2 (HGNC Symbol)
Synonyms	DCT1, DMT1, NRAMP2
Description	Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	50979401 - 51028566
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110911 (version 78.38)
Entrez gene	4891
UniProt	P49281 (UniProt - Evidence at protein level)
neXtProt	NX_P49281
Antibodypedia	SLC11A2 antibodies

PROTEIN BROWSER

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ENST00000262051		ENST00000262052		ENST00000394904		ENST00000541174		ENST00000545993		ENST00000546488		ENST00000546743		ENST00000547198		ENST00000547579		ENST00000547688		ENST00000547732		ENST00000548150		ENST00000548193		ENST00000549110		ENST00000550714

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC11A2-001	ENSP00000449200 ENST00000547688	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8W1P7 [Target identity:81%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:69%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8VWB0 [Target identity:25%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:25%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:16%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:14%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	590	64.7	No	>9
SLC11A2-002	ENSP00000262052 ENST00000262052	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8W1P7 [Target identity:85%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:73%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8VWB0 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:17%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:15%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	561	61.5	No	>9
SLC11A2-003	ENSP00000446914 ENST00000546743	F8W1P7 Show all » « Hide F8W1P7 [Target identity:100%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:85%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8W1F2 [Target identity:31%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:20%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:18%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	482	52.8	No	>9
SLC11A2-005	ENSP00000444542 ENST00000541174	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8W1P7 [Target identity:85%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:73%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8VWB0 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:17%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:15%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	561	61.5	No	>9
SLC11A2-006	ENSP00000262051 ENST00000262051	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8VWB0 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:17%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:15%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	568	62.3	No	>9
SLC11A2-007	ENSP00000446769 ENST00000547198	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8VWB0 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:17%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:15%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	568	62.3	No	>9
SLC11A2-008	ENSP00000442810 ENST00000545993	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8W1P7 [Target identity:86%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:73%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8W1F2 [Target identity:26%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:17%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:15%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006828 [manganese ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071421 [manganese ion transmembrane transport] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport]	557	61	No	>9
SLC11A2-010	ENSP00000447482 ENST00000547579	F8W1F2 Show all » « Hide F8W1F2 [Target identity:100%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:65%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:58%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	150	16.5	No	4
SLC11A2-011	ENSP00000446984 ENST00000550714	F8W1C0 Show all » « Hide F8W1C0 [Target identity:99%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446984} F8W154 [Target identity:66%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:58%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	148	16.1	No	4
SLC11A2-012	ENSP00000450389 ENST00000546488	F8VR36 Show all » « Hide F8VR36 [Target identity:99%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000450389}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	154	16.9	No	3
SLC11A2-014	ENSP00000447102 ENST00000547732	F8W154 Show all » « Hide F8W154 [Target identity:100%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:88%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	98	10.6	No	2
SLC11A2-017	ENSP00000447334 ENST00000549110	F8VZL6 Show all » « Hide F8VZL6 [Target identity:100%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	87	9.5	No	2
SLC11A2-020	ENSP00000449209 ENST00000548193	F8VWB0 Show all » « Hide F8VWB0 [Target identity:100%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane]	149	16.3	No	2
SLC11A2-025	ENSP00000448273 ENST00000548150		Show » « Hide Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)		3	0.4	No	0
SLC11A2-201	ENSP00000378364 ENST00000394904	P49281 Show all » « Hide P49281 [Direct mapping] Natural resistance-associated macrophage protein 2 F8W1P7 [Target identity:81%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000446914} B3KY44 [Target identity:69%; Query identity:100%] Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c {ECO:0000313\|EMBL:EAW58161.1}; cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2 {ECO:0000313\|EMBL:BAG54706.1} F8VWB0 [Target identity:25%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000449209} F8W1F2 [Target identity:25%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447482} F8W154 [Target identity:16%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447102} F8VZL6 [Target identity:14%; Query identity:100%] Natural resistance-associated macrophage protein 2 {ECO:0000313\|Ensembl:ENSP00000447334}	Show » « Hide Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000041 [transition metal ion transport] GO:0001666 [response to hypoxia] GO:0003032 [detection of oxygen] GO:0005215 [transporter activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005381 [iron ion transmembrane transporter activity] GO:0005384 [manganese ion transmembrane transporter activity] GO:0005385 [zinc ion transmembrane transporter activity] GO:0005506 [iron ion binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005773 [vacuole] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0006778 [porphyrin-containing compound metabolic process] GO:0006779 [porphyrin-containing compound biosynthetic process] GO:0006783 [heme biosynthetic process] GO:0006810 [transport] GO:0006824 [cobalt ion transport] GO:0006825 [copper ion transport] GO:0006826 [iron ion transport] GO:0006828 [manganese ion transport] GO:0006878 [cellular copper ion homeostasis] GO:0006879 [cellular iron ion homeostasis] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007611 [learning or memory] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0010039 [response to iron ion] GO:0010042 [response to manganese ion] GO:0010288 [response to lead ion] GO:0012505 [endomembrane system] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015086 [cadmium ion transmembrane transporter activity] GO:0015087 [cobalt ion transmembrane transporter activity] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015094 [lead ion transmembrane transporter activity] GO:0015099 [nickel cation transmembrane transporter activity] GO:0015100 [vanadium ion transmembrane transporter activity] GO:0015295 [solute:proton symporter activity] GO:0015675 [nickel cation transport] GO:0015676 [vanadium ion transport] GO:0015684 [ferrous iron transport] GO:0015692 [lead ion transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016151 [nickel cation binding] GO:0016324 [apical plasma membrane] GO:0022890 [inorganic cation transmembrane transporter activity] GO:0030145 [manganese ion binding] GO:0031410 [cytoplasmic vesicle] GO:0031902 [late endosome membrane] GO:0034599 [cellular response to oxidative stress] GO:0035444 [nickel cation transmembrane transport] GO:0045177 [apical part of cell] GO:0045178 [basal part of cell] GO:0046686 [response to cadmium ion] GO:0046870 [cadmium ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048813 [dendrite morphogenesis] GO:0048821 [erythrocyte development] GO:0050897 [cobalt ion binding] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:0060586 [multicellular organismal iron ion homeostasis] GO:0070574 [cadmium ion transmembrane transport] GO:0070627 [ferrous iron import] GO:0070826 [paraferritin complex] GO:0071281 [cellular response to iron ion] GO:0071356 [cellular response to tumor necrosis factor] GO:0071421 [manganese ion transmembrane transport] GO:0071456 [cellular response to hypoxia] GO:0071577 [zinc ion transmembrane transport] GO:0098655 [cation transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] GO:1902861 [copper ion import into cell]	590	64.7	No	>9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx