Tissue expression of PSMD9 - Summary - The Human Protein Atlas

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PSMD9

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	PSMD9
Gene description	Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. HPA040512 , HPA044220
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	PSMD9 (HGNC Symbol)
Synonyms	p27, Rpn4
Description	Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 (HGNC Symbol)
Entrez gene summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	121888731 - 121918297
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110801 (version 78.38)
Entrez gene	5715
UniProt	O00233 (UniProt - Evidence at protein level)
neXtProt	NX_O00233
Antibodypedia	PSMD9 antibodies

PROTEIN BROWSER

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ENST00000261817		ENST00000538613		ENST00000541212		ENST00000542602

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
PSMD9-001	ENSP00000261817 ENST00000261817	J3KN29 Show all » « Hide J3KN29 [Target identity:100%; Query identity:100%] 26S proteasome non-ATPase regulatory subunit 9 {ECO:0000313\|Ensembl:ENSP00000261817}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	222	24.6	No
PSMD9-003	ENSP00000440485 ENST00000541212	O00233 Show all » « Hide O00233 [Direct mapping] 26S proteasome non-ATPase regulatory subunit 9	Show » « Hide Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005838 [proteasome regulatory particle] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008540 [proteasome regulatory particle, base subcomplex] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0032024 [positive regulation of insulin secretion] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043425 [bHLH transcription factor binding] GO:0044281 [small molecule metabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046676 [negative regulation of insulin secretion] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070682 [proteasome regulatory particle assembly]	223	24.7	No
PSMD9-005	ENSP00000443081 ENST00000538613	F5H5V4 Show all » « Hide F5H5V4 [Target identity:100%; Query identity:100%] 26S proteasome non-ATPase regulatory subunit 9 {ECO:0000313\|Ensembl:ENSP00000443081}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		153	16.9	No
PSMD9-011	ENSP00000443772 ENST00000542602	O00233 Show all » « Hide O00233 [Direct mapping] 26S proteasome non-ATPase regulatory subunit 9	Show » « Hide Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005838 [proteasome regulatory particle] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008540 [proteasome regulatory particle, base subcomplex] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0032024 [positive regulation of insulin secretion] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043425 [bHLH transcription factor binding] GO:0044281 [small molecule metabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046676 [negative regulation of insulin secretion] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070682 [proteasome regulatory particle assembly]	118	13.1	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx