PHOX2B

GENERAL INFORMATION

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Gene name

PHOX2B

Gene description

Paired-like homeobox 2b

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (adrenal gland)
GTEx:Group enriched (adrenal gland, colon, small intestine)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (adrenal gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (adrenal gland, colon, small intestine)

Organ

Expression



GENE INFORMATION

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Gene name

PHOX2B (HGNC Symbol)

Synonyms

NBPhox, Phox2b, PMX2B

Description

Paired-like homeobox 2b (HGNC Symbol)

Entrez gene summary

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

p13

Chromosome location (bp)

41744082 - 41748970

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109132 (version 78.38)

Entrez gene

8929

UniProt

Q99453 (UniProt - Evidence at protein level)

neXtProt

NX_Q99453

Antibodypedia

PHOX2B antibodies


PROTEIN BROWSER

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ENST00000226382
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHOX2B-001 ENSP00000226382
ENST00000226382
Q99453
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