Tissue expression of GCK - Summary - The Human Protein Atlas

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GCK

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	GCK
Gene description	Glucokinase (hexokinase 4)
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in all tissues at variable levels. Highest levels in glandular epithelia of gastrointestinal tract.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 2 antibodies. HPA007034 , HPA007093
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Mixed

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enhanced (liver)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	GCK (HGNC Symbol)
Synonyms	HK4, MODY2
Description	Glucokinase (hexokinase 4) (HGNC Symbol)
Entrez gene summary	Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
Chromosome	7
Cytoband	p13
Chromosome location (bp)	44144271 - 44198170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106633 (version 78.38)
Entrez gene	2645
UniProt	P35557 (UniProt - Evidence at protein level)
neXtProt	NX_P35557
Antibodypedia	GCK antibodies

PROTEIN BROWSER

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ENST00000336642		ENST00000345378		ENST00000395796		ENST00000403799		ENST00000437084		ENST00000616242

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
GCK-001	ENSP00000384247 ENST00000403799	P35557 Show all » « Hide P35557 [Direct mapping] Glucokinase Q53Y25 [Target identity:100%; Query identity:100%] Glucokinase (Hexokinase 4, maturity onset diabetes of the young 2) {ECO:0000313\|EMBL:AAP35711.1}; Glucokinase (Hexokinase 4, maturity onset diabetes of the young 2), isoform CRA_b {ECO:0000313\|EMBL:EAW61115.1} M4PPE1 [Target identity:15%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08215.1} M4PS83 [Target identity:10%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08223.1}	Show » « Hide Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014)	Show » « Hide GO:0001678 [cellular glucose homeostasis] GO:0004340 [glucokinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005536 [glucose binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006110 [regulation of glycolytic process] GO:0008645 [hexose transport] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0031018 [endocrine pancreas development] GO:0032024 [positive regulation of insulin secretion] GO:0032869 [cellular response to insulin stimulus] GO:0042593 [glucose homeostasis] GO:0044281 [small molecule metabolic process] GO:0044320 [cellular response to leptin stimulus] GO:0045721 [negative regulation of gluconeogenesis] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0050796 [regulation of insulin secretion] GO:0051594 [detection of glucose] GO:0055085 [transmembrane transport]	465	52.2	No
GCK-002	ENSP00000223366 ENST00000345378	P35557 Show all » « Hide P35557 [Direct mapping] Glucokinase M4PPE1 [Target identity:15%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08215.1} M4PS83 [Target identity:10%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08223.1}	Show » « Hide Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014)	Show » « Hide GO:0000287 [magnesium ion binding] GO:0001678 [cellular glucose homeostasis] GO:0004340 [glucokinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005536 [glucose binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005884 [actin filament] GO:0005938 [cell cortex] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0006003 [fructose 2,6-bisphosphate metabolic process] GO:0006006 [glucose metabolic process] GO:0006096 [glycolytic process] GO:0006110 [regulation of glycolytic process] GO:0006739 [NADP metabolic process] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008645 [hexose transport] GO:0009749 [response to glucose] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0019903 [protein phosphatase binding] GO:0019932 [second-messenger-mediated signaling] GO:0030141 [secretory granule] GO:0031018 [endocrine pancreas development] GO:0032024 [positive regulation of insulin secretion] GO:0032811 [negative regulation of epinephrine secretion] GO:0032869 [cellular response to insulin stimulus] GO:0042149 [cellular response to glucose starvation] GO:0042327 [positive regulation of phosphorylation] GO:0042593 [glucose homeostasis] GO:0043266 [regulation of potassium ion transport] GO:0043531 [ADP binding] GO:0044281 [small molecule metabolic process] GO:0044320 [cellular response to leptin stimulus] GO:0045180 [basal cortex] GO:0045721 [negative regulation of gluconeogenesis] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045821 [positive regulation of glycolytic process] GO:0046835 [carbohydrate phosphorylation] GO:0050796 [regulation of insulin secretion] GO:0051156 [glucose 6-phosphate metabolic process] GO:0051594 [detection of glucose] GO:0055085 [transmembrane transport] GO:0055088 [lipid homeostasis] GO:0070509 [calcium ion import]	466	52.1	No
GCK-003	ENSP00000379142 ENST00000395796	P35557 Show all » « Hide P35557 [Direct mapping] Glucokinase M4PPE1 [Target identity:15%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08215.1} M4PS83 [Target identity:10%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08223.1}	Show » « Hide Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014)	Show » « Hide GO:0001678 [cellular glucose homeostasis] GO:0004340 [glucokinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005536 [glucose binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006110 [regulation of glycolytic process] GO:0008645 [hexose transport] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0031018 [endocrine pancreas development] GO:0032024 [positive regulation of insulin secretion] GO:0032869 [cellular response to insulin stimulus] GO:0042593 [glucose homeostasis] GO:0044281 [small molecule metabolic process] GO:0044320 [cellular response to leptin stimulus] GO:0045721 [negative regulation of gluconeogenesis] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0050796 [regulation of insulin secretion] GO:0051594 [detection of glucose] GO:0055085 [transmembrane transport]	464	52	No
GCK-004	ENSP00000402840 ENST00000437084	C9JQD1 Show all » « Hide C9JQD1 [Target identity:100%; Query identity:100%] Glucokinase {ECO:0000313\|Ensembl:ENSP00000402840} M4PPE1 [Target identity:15%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08215.1} M4PS83 [Target identity:11%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08223.1}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0004396 [hexokinase activity] GO:0005524 [ATP binding] GO:0005975 [carbohydrate metabolic process] GO:0006096 [glycolytic process] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0046835 [carbohydrate phosphorylation]	448	50.1	No
GCK-006	ENSP00000338009 ENST00000336642	H7BXV0 Show all » « Hide H7BXV0 [Target identity:100%; Query identity:100%] Glucokinase {ECO:0000313\|Ensembl:ENSP00000338009} M4PPE1 [Target identity:47%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08215.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0005524 [ATP binding] GO:0005975 [carbohydrate metabolic process] GO:0006096 [glycolytic process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016773 [phosphotransferase activity, alcohol group as acceptor]	149	15.9	No
GCK-201	ENSP00000482149 ENST00000616242	P35557 Show all » « Hide P35557 [Direct mapping] Glucokinase M4PPE1 [Target identity:15%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08215.1} M4PS83 [Target identity:10%; Query identity:100%] Glucokinase {ECO:0000313\|EMBL:AGH08223.1}	Show » « Hide Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014)	Show » « Hide GO:0001678 [cellular glucose homeostasis] GO:0004340 [glucokinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005536 [glucose binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006110 [regulation of glycolytic process] GO:0008645 [hexose transport] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0031018 [endocrine pancreas development] GO:0032024 [positive regulation of insulin secretion] GO:0032869 [cellular response to insulin stimulus] GO:0042593 [glucose homeostasis] GO:0044281 [small molecule metabolic process] GO:0044320 [cellular response to leptin stimulus] GO:0045721 [negative regulation of gluconeogenesis] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0050796 [regulation of insulin secretion] GO:0051594 [detection of glucose] GO:0055085 [transmembrane transport]	464	52	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx