CDK6

GENERAL INFORMATION

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Gene name

CDK6

Gene description

Cyclin-dependent kinase 6

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in many cell types which in cases was combined with nuclear expression. Highest expression in bone marrow poietic cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA002637 , CAB004363
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

CDK6 (HGNC Symbol)

Synonyms

PLSTIRE

Description

Cyclin-dependent kinase 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Chromosome

7

Cytoband

q21.2

Chromosome location (bp)

92604921 - 92836594

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105810 (version 78.38)

Entrez gene

1021

UniProt

Q00534 (UniProt - Evidence at protein level)

neXtProt

NX_Q00534

Antibodypedia

CDK6 antibodies


PROTEIN BROWSER

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ENST00000265734
 
ENST00000424848
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK6-001 ENSP00000265734
ENST00000265734
Q00534
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Show » Show » 326 36.9 No 0
CDK6-002 ENSP00000397087
ENST00000424848
Q00534
Show all »
Show » Show » 326 36.9 No 0