ATP1A3 - Gene info - The Human Protein Atlas

Gene name

ATP1A3 (HGNC Symbol)

Synonyms

DYT12

Description

ATPase, Na+/K+ transporting, alpha 3 polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

Cytoband

q13.2

Chromosome location (bp)

41966582 - 41997497

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105409 (version 78.38)

Entrez gene

478

UniProt

P13637 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP1A3-001

ENSP00000302397
ENST00000302102

P13637
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P13637 [Direct mapping]
Sodium/potassium-transporting ATPase subunit alpha-3
M0R116 [Target identity:97%; Query identity:100%]
Sodium/potassium-transporting ATPase subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000471581}
M0QXF2 [Target identity:17%; Query identity:100%]
Sodium/potassium-transporting ATPase subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000469129}
Q58I21 [Target identity:11%; Query identity:100%]
Na+/K+ transporting ATPase alpha 3 polypeptide {ECO:0000313|EMBL:AAX55910.1}

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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000166 [nucleotide binding]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006754 [ATP biosynthetic process]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0010107 [potassium ion import]
GO:0015077 [monovalent inorganic cation transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0019829 [cation-transporting ATPase activity]
GO:0030007 [cellular potassium ion homeostasis]
GO:0031982 [vesicle]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0051087 [chaperone binding]
GO:0055085 [transmembrane transport]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0098655 [cation transmembrane transport]
GO:1903416 [response to glycoside]
GO:1990239 [steroid hormone binding]

1013

111.7

ATP1A3-005

ENSP00000471581
ENST00000602133

M0R116
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M0R116 [Target identity:100%; Query identity:100%]
Sodium/potassium-transporting ATPase subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000471581}
M0QXF2 [Target identity:18%; Query identity:100%]
Sodium/potassium-transporting ATPase subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000469129}
Q58I21 [Target identity:11%; Query identity:100%]
Na+/K+ transporting ATPase alpha 3 polypeptide {ECO:0000313|EMBL:AAX55910.1}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000166 [nucleotide binding]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005524 [ATP binding]
GO:0006754 [ATP biosynthetic process]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0015077 [monovalent inorganic cation transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0019829 [cation-transporting ATPase activity]
GO:0046872 [metal ion binding]
GO:0098655 [cation transmembrane transport]

983

108.3

ATP1A3-007

ENSP00000437577
ENST00000543770

P13637
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P13637 [Direct mapping]
Sodium/potassium-transporting ATPase subunit alpha-3
M0R116 [Target identity:95%; Query identity:100%]
Sodium/potassium-transporting ATPase subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000471581}
M0QXF2 [Target identity:17%; Query identity:100%]
Sodium/potassium-transporting ATPase subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000469129}
Q58I21 [Target identity:11%; Query identity:100%]
Na+/K+ transporting ATPase alpha 3 polypeptide {ECO:0000313|EMBL:AAX55910.1}

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1024

113.1

ATP1A3-008

ENSP00000444688
ENST00000545399

P13637
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GO:0000166 [nucleotide binding]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006754 [ATP biosynthetic process]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007613 [memory]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0010107 [potassium ion import]
GO:0015077 [monovalent inorganic cation transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0019829 [cation-transporting ATPase activity]
GO:0030007 [cellular potassium ion homeostasis]
GO:0030424 [axon]
GO:0031748 [D1 dopamine receptor binding]
GO:0031982 [vesicle]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0036376 [sodium ion export from cell]
GO:0042493 [response to drug]
GO:0043209 [myelin sheath]
GO:0044326 [dendritic spine neck]
GO:0044327 [dendritic spine head]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0051087 [chaperone binding]
GO:0055085 [transmembrane transport]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0098655 [cation transmembrane transport]
GO:1903416 [response to glycoside]
GO:1990239 [steroid hormone binding]

1026

113.1

ATP1A3-011

ENSP00000469129
ENST00000473086

M0QXF2
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M0QXF2 [Target identity:70%; Query identity:100%]
Sodium/potassium-transporting ATPase subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000469129}
Q58I21 [Target identity:45%; Query identity:100%]
Na+/K+ transporting ATPase alpha 3 polypeptide {ECO:0000313|EMBL:AAX55910.1}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000166 [nucleotide binding]
GO:0016021 [integral component of membrane]
GO:0046872 [metal ion binding]

251

27.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.