PRKD2

GENERAL INFORMATION

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Gene name

PRKD2

Gene description

Protein kinase D2

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal cells showed weak to moderate cytoplasmic staining. Subset of lymphoid tissues were strongly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA021490
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PRKD2 (HGNC Symbol)

Synonyms

DKFZP586E0820, HSPC187, PKD2

Description

Protein kinase D2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.32

Chromosome location (bp)

46674275 - 46717127

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105287 (version 78.38)

Entrez gene

25865

UniProt

Q9BZL6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BZL6

Antibodypedia

PRKD2 antibodies


PROTEIN BROWSER

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ENST00000291281
 
ENST00000433867
 
ENST00000593363
 
ENST00000595132
 
ENST00000595515
 
ENST00000598633
 
ENST00000600194
 
ENST00000601605
 
ENST00000601806
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKD2-001 ENSP00000291281
ENST00000291281
Q9BZL6
Show all »
Show » Show » 878 96.7 No 0
PRKD2-002 ENSP00000469106
ENST00000601806
Q8NCK8
Show all »
Show » Show » 721 80.1 No 0
PRKD2-004 ENSP00000470804
ENST00000595515
B4DTS2
Show all »
Show » Show » 888 97.7 No 0
PRKD2-006 ENSP00000472744
ENST00000600194
Q8NCK8
Show all »
Show » Show » 721 80.1 No 0
PRKD2-010 ENSP00000472987
ENST00000593363
M0R346
Show all »
Show » Show » 69 6.8 No 0
PRKD2-011 ENSP00000470919
ENST00000598633
M0R012
Show all »
Show » 18 1.9 No 0
PRKD2-013 ENSP00000470363
ENST00000595132
M0QZ82
Show all »
Show » Show » 67 7.2 No 0
PRKD2-015 ENSP00000470442
ENST00000601605
M0QZC2
Show all »
Show » Show » 94 10 No 0
PRKD2-201 ENSP00000393978
ENST00000433867
Q9BZL6
Show all »
Show » Show » 878 96.7 No 0