Tissue expression of AKT2 - Summary - The Human Protein Atlas

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AKT2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	AKT2
Gene description	V-akt murine thymoma viral oncogene homolog 2
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	22
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Data reliability	Uncertain based on 1 antibody. CAB004204
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

N/A

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	AKT2
Synonyms
Description	V-akt murine thymoma viral oncogene homolog 2 (HGNC Symbol)
Entrez gene summary	This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	40230317 - 40285536
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105221 (version 78.38)
Entrez gene	208
UniProt	P31751 (UniProt - Evidence at protein level)
neXtProt	NX_P31751
Antibodypedia	AKT2 antibodies

PROTEIN BROWSER

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ENST00000311278		ENST00000358335		ENST00000392037		ENST00000392038		ENST00000416362		ENST00000416994		ENST00000423127		ENST00000424901		ENST00000427375		ENST00000441941		ENST00000452077		ENST00000456441		ENST00000476247		ENST00000486368		ENST00000497948		ENST00000578123		ENST00000578310		ENST00000578615		ENST00000579047		ENST00000580747		ENST00000583859		ENST00000596634

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
AKT2-001	ENSP00000375892 ENST00000392038	P31751 Show all » « Hide P31751 [Direct mapping] RAC-beta serine/threonine-protein kinase B4DG79 [Target identity:87%; Query identity:100%] cDNA FLJ55487, highly similar to RAC-beta serine/threonine-protein kinase {ECO:0000313\|EMBL:BAG57690.1} B3KP61 [Target identity:79%; Query identity:100%] cDNA FLJ31217 fis, clone KIDNE2004095, highly similar to RAC-beta serine/threonine-protein kinase {ECO:0000313\|EMBL:BAG51573.1} C9JHS6 [Target identity:38%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396968} J3QLS6 [Target identity:32%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463686} M0QZK3 [Target identity:31%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000470604} E7EVP8 [Target identity:27%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000404083} F6YBB4 [Target identity:27%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000407999} J3KRI8 [Target identity:27%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462022} A8MX96 [Target identity:27%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000375891} C9JIJ1 [Target identity:24%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:22%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3QL45 [Target identity:22%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463368} J3KSY8 [Target identity:20%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} C9J258 [Target identity:19%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} J3QQM6 [Target identity:19%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9JIF6 [Target identity:13%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0016301 [kinase activity] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030334 [regulation of cell migration] GO:0031340 [positive regulation of vesicle fusion] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032287 [peripheral nervous system myelin maintenance] GO:0032587 [ruffle membrane] GO:0032859 [activation of Ral GTPase activity] GO:0032869 [cellular response to insulin stimulus] GO:0045444 [fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0046326 [positive regulation of glucose import] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0065002 [intracellular protein transmembrane transport] GO:0071156 [regulation of cell cycle arrest] GO:0072659 [protein localization to plasma membrane] GO:0090314 [positive regulation of protein targeting to membrane] GO:2000147 [positive regulation of cell motility] GO:2001275 [positive regulation of glucose import in response to insulin stimulus]	481	55.8	No
AKT2-005	ENSP00000404083 ENST00000452077	E7EVP8 Show all » « Hide E7EVP8 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000404083} A8MX96 [Target identity:99%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000375891} F6YBB4 [Target identity:98%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000407999} J3KRI8 [Target identity:97%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462022} C9JIJ1 [Target identity:88%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:79%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3KSY8 [Target identity:73%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} J3QQM6 [Target identity:71%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9J258 [Target identity:70%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:50%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		134	15.7	No
AKT2-006	ENSP00000396532 ENST00000456441	C9JC83 Show all » « Hide C9JC83 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3KSY8 [Target identity:92%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} J3QQM6 [Target identity:89%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9J258 [Target identity:88%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:62%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		107	12.8	No
AKT2-007	ENSP00000403842 ENST00000423127	C9JIJ1 Show all » « Hide C9JIJ1 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:89%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3KSY8 [Target identity:83%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} J3QQM6 [Target identity:80%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9J258 [Target identity:79%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:56%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		119	14.1	No
AKT2-008	ENSP00000392458 ENST00000416994	C9J258 Show all » « Hide C9J258 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:70%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		95	11.3	No
AKT2-010	ENSP00000407999 ENST00000416362	A8MX96 Show all » « Hide A8MX96 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000375891} F6YBB4 [Target identity:99%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000407999} J3KRI8 [Target identity:97%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462022} C9JIJ1 [Target identity:89%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:80%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3KSY8 [Target identity:74%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} J3QQM6 [Target identity:72%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9J258 [Target identity:71%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:50%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		133	15.5	No
AKT2-011	ENSP00000403890 ENST00000427375	C9JIF6 Show all » « Hide C9JIF6 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		67	7.9	No
AKT2-012	ENSP00000396968 ENST00000441941	C9JHS6 Show all » « Hide C9JHS6 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396968} J3QLS6 [Target identity:85%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463686} M0QZK3 [Target identity:82%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000470604} A8MX96 [Target identity:72%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000375891} E7EVP8 [Target identity:72%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000404083} F6YBB4 [Target identity:71%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000407999} J3KRI8 [Target identity:70%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462022} C9JIJ1 [Target identity:64%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:58%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3KSY8 [Target identity:53%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} J3QQM6 [Target identity:52%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9J258 [Target identity:51%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:36%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	184	21.3	No
AKT2-014	ENSP00000375891 ENST00000392037	A8MX96 Show all » « Hide A8MX96 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000375891} F6YBB4 [Target identity:99%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000407999} J3KRI8 [Target identity:97%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462022} C9JIJ1 [Target identity:89%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:80%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3KSY8 [Target identity:74%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} J3QQM6 [Target identity:72%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9J258 [Target identity:71%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:50%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		133	15.5	No
AKT2-021	ENSP00000472382 ENST00000497948		Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	117	13.1	No
AKT2-025	ENSP00000471369 ENST00000579047	M0R0P9 Show all » « Hide M0R0P9 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000471369} J3QL45 [Target identity:23%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463368}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	450	51.6	No
AKT2-027	ENSP00000309428 ENST00000311278	Q0VAN0 Show all » « Hide Q0VAN0 [Target identity:100%; Query identity:100%] AKT2 protein {ECO:0000313\|EMBL:AAI20996.1}; RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000309428} C9JHS6 [Target identity:42%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396968} J3QLS6 [Target identity:35%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463686} M0QZK3 [Target identity:34%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000470604} A8MX96 [Target identity:30%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000375891} E7EVP8 [Target identity:30%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000404083} F6YBB4 [Target identity:30%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000407999} J3KRI8 [Target identity:29%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462022} C9JIJ1 [Target identity:27%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:24%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3QL45 [Target identity:24%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463368} J3KSY8 [Target identity:22%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} C9J258 [Target identity:21%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} J3QQM6 [Target identity:21%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9JIF6 [Target identity:15%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	438	51.1	No
AKT2-029	ENSP00000462022 ENST00000578123	J3KRI8 Show all » « Hide J3KRI8 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462022} C9JIJ1 [Target identity:91%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:82%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3KSY8 [Target identity:76%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} C9J258 [Target identity:73%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} J3QQM6 [Target identity:73%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9JIF6 [Target identity:51%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		130	15.2	No
AKT2-030	ENSP00000462715 ENST00000583859	J3KSY8 Show all » « Hide J3KSY8 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} J3QQM6 [Target identity:96%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9J258 [Target identity:95%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:67%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		99	11.9	No
AKT2-032	ENSP00000463806 ENST00000580747	C9J258 Show all » « Hide C9J258 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:70%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		95	11.3	No
AKT2-033	ENSP00000463686 ENST00000486368	J3QLS6 Show all » « Hide J3QLS6 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463686} M0QZK3 [Target identity:96%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000470604} E7EVP8 [Target identity:85%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000404083} A8MX96 [Target identity:84%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000375891} F6YBB4 [Target identity:84%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000407999} J3KRI8 [Target identity:82%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462022} C9JIJ1 [Target identity:75%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:68%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3KSY8 [Target identity:63%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} J3QQM6 [Target identity:61%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9J258 [Target identity:60%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:42%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		157	18.3	No
AKT2-035	ENSP00000463262 ENST00000578615	J3QKW1 Show all » « Hide J3QKW1 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463262}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	292	33.5	No
AKT2-036	ENSP00000462919 ENST00000578310		Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	53	5.9	No
AKT2-041	ENSP00000463368 ENST00000476247	J3QL45 Show all » « Hide J3QL45 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463368}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	106	12.4	No
AKT2-042	ENSP00000351095 ENST00000358335		Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		126	14.7	No
AKT2-045	ENSP00000470604 ENST00000596634	M0QZK3 Show all » « Hide M0QZK3 [Target identity:100%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000470604} A8MX96 [Target identity:88%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000375891} E7EVP8 [Target identity:88%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000404083} F6YBB4 [Target identity:87%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000407999} J3KRI8 [Target identity:86%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462022} C9JIJ1 [Target identity:78%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:70%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3KSY8 [Target identity:65%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} J3QQM6 [Target identity:63%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9J258 [Target identity:62%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} C9JIF6 [Target identity:44%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		151	17.5	No
AKT2-201	ENSP00000399532 ENST00000424901	Q0VAN0 Show all » « Hide Q0VAN0 [Target identity:100%; Query identity:100%] AKT2 protein {ECO:0000313\|EMBL:AAI20996.1}; RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000309428} C9JHS6 [Target identity:42%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396968} J3QLS6 [Target identity:35%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463686} M0QZK3 [Target identity:34%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000470604} A8MX96 [Target identity:30%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000375891} E7EVP8 [Target identity:30%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000404083} F6YBB4 [Target identity:30%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000407999} J3KRI8 [Target identity:29%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462022} C9JIJ1 [Target identity:27%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403842} C9JC83 [Target identity:24%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000396532} J3QL45 [Target identity:24%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463368} J3KSY8 [Target identity:22%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000462715} C9J258 [Target identity:21%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000392458} J3QQM6 [Target identity:21%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000463806} C9JIF6 [Target identity:15%; Query identity:100%] RAC-beta serine/threonine-protein kinase {ECO:0000313\|Ensembl:ENSP00000403890}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	438	51.1	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx