SMAD7

GENE INFORMATION

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Gene name

SMAD7 (HGNC Symbol)

Synonyms

MADH7, MADH8

Description

SMAD family member 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

18

Cytoband

q21.1

Chromosome location (bp)

48919853 - 48950711

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101665 (version 78.38)

Entrez gene

4092

UniProt

O15105 (UniProt - Evidence at protein level)

neXtProt

NX_O15105

Antibodypedia

SMAD7 antibodies
 

PROTEIN VIEW

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SMAD7-001
 
SMAD7-002
 
SMAD7-005
 
SMAD7-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMAD7-001 ENSP00000262158
ENST00000262158
O15105
Show all »
Show » Show » 426 46.4 No 0
SMAD7-002 ENSP00000466902
ENST00000591805
O15105
Show all »
Show » Show » 211 23.9 No 0
SMAD7-005 ENSP00000467621
ENST00000589634
O15105
Show all »
Show » Show » 425 46.4 No 0
SMAD7-007 ENSP00000465590
ENST00000586093
K7EKF0
Show all »
Show » Show » 158 17.6 No 0