HCK

GENERAL INFORMATION

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Gene name

HCK

Gene description

HCK proto-oncogene, Src family tyrosine kinase

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (appendix)
GTEx:Group enriched (lung, spleen)

Protein evidence

Evidence at protein level

Protein localization

Weak to moderate staining was observed in most normal tissues. Syncytiotrophoblasts showed strong positivity while cytotrophoblasts were unstained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB005195
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (appendix)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (lung, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

HCK (HGNC Symbol)

Synonyms

JTK9

Description

HCK proto-oncogene, Src family tyrosine kinase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Chromosome

20

Cytoband

q11.21

Chromosome location (bp)

32052188 - 32101856

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101336 (version 78.38)

Entrez gene

3055

UniProt

P08631 (UniProt - Evidence at protein level)

neXtProt

NX_P08631

Antibodypedia

HCK antibodies


PROTEIN BROWSER

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ENST00000375852
 
ENST00000375862
 
ENST00000518730
 
ENST00000520553
 
ENST00000534862
 
ENST00000538448
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HCK-001 ENSP00000365012
ENST00000375852
J3KPD6
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Show » Show » 526 59.6 No 0
HCK-002 ENSP00000365022
ENST00000375862
H0Y3C5
Show all »
Show » Show » 525 59.5 No 0
HCK-006 ENSP00000429848
ENST00000520553
P08631
Show all »
Show » Show » 505 57.3 No 0
HCK-007 ENSP00000427757
ENST00000518730
P08631
Show all »
Show » Show » 504 57.2 No 0
HCK-201 ENSP00000444986
ENST00000534862
J3KPD6
Show all »
Show » Show » 526 59.6 No 0
HCK-202 ENSP00000441169
ENST00000538448
P08631
Show all »
Show » Show » 505 57.3 No 0