HNF4A

GENERAL INFORMATION

? »

Gene name

HNF4A

Gene description

Hepatocyte nuclear factor 4, alpha

Protein class

Disease related genes
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Group enriched (colon, duodenum, kidney, liver, rectum, small intestine, stomach)
GTEx:Group enriched (colon, kidney, liver, small intestine)

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in intestinal tract, liver and kidney.

ANTIBODY RELIABILITY

? »

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA004712 , CAB019417
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Group enriched (colon, duodenum, kidney, liver, rectum, small intestine, stomach)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (colon, kidney, liver, small intestine)

Organ

Expression



GENE INFORMATION

? »

Gene name

HNF4A (HGNC Symbol)

Synonyms

HNF4, MODY, MODY1, NR2A1, TCF14

Description

Hepatocyte nuclear factor 4, alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

44355700 - 44432845

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101076 (version 78.38)

Entrez gene

3172

UniProt

P41235 (UniProt - Evidence at protein level)

neXtProt

NX_P41235

Antibodypedia

HNF4A antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000316099
 
ENST00000316673
 
ENST00000415691
 
ENST00000443598
 
ENST00000457232
 
ENST00000609262
 
ENST00000609795
 
ENST00000619550
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HNF4A-001 ENSP00000315180
ENST00000316673
P41235
Show all »
Show » Show » 452 50.1 No 0
HNF4A-002 ENSP00000312987
ENST00000316099
P41235
Show all »
Show » Show » 474 52.8 No 0
HNF4A-004 ENSP00000410911
ENST00000443598
P41235
Show all »
Show » Show » 417 46.6 No 0
HNF4A-005 ENSP00000396216
ENST00000457232
P41235
Show all »
Show » Show » 442 49 No 0
HNF4A-006 ENSP00000412111
ENST00000415691
P41235
Show all »
Show » Show » 464 51.6 No 0
HNF4A-007 ENSP00000476609
ENST00000609795
P41235
Show all »
Show » Show » 395 44 No 0
HNF4A-008 ENSP00000476310
ENST00000609262
B9VVT8
Show all »
Show » Show » 103 11.5 No 0
HNF4A-201 ENSP00000481331
ENST00000619550
B9VVT8
Show all »
Show » Show » 449 50 No 0