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GENERAL INFORMATION
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Protein class
Protein class the gene product belongs to according to selected gene lists. List of protein classes.
Predicted localization
Protein localization predicted from several bioinformatic algorithms. More info...
Number of transcripts
Number of protein-coding transcribed from this gene as defined by Ensembl.
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Gene name |
PCK2 |
Gene description |
Phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
Protein class |
Citric acid cycle related proteins Disease related genes Enzymes Mitochondrial proteins Plasma proteins Potential drug targets Predicted intracellular proteins |
Predicted localization |
Intracellular |
Number of transcripts |
9 |
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HUMAN PROTEIN ATLAS INFORMATION
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RNA tissue category
The RNA tissue category is based on mRNA expression levels in 32 different tissues ( RNA assay description).
The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, not detected, and mixed.
RNA tissue category is calculated separately both for internally generated Human Protein Atlas (HPA) RNA-seq data, as
well as RNA-seq data from the Genotype-Tissue Expression ( GTEx) consortium.
Protein evidence
Protein evidence scores are generated from several independent sources
and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence or iv) not available.
Protein localization
A summary of the overall protein expression pattern across the analyzed tissues. The summary is based on knowledge-based
annotation ( Annotation description). For genes pending
knowledge-based annotation, the protein localization refers to the antibody staining pattern.
"RNA-based expert annotation gave inconconclusive results" is shown for genes analyzed with a knowledge-based approach where
available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with
immunohistochemistry-data to yield a reliable estimation of the protein expression profile.
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RNA tissue category |
HPA: | Group enriched (duodenum, kidney, liver, small intestine) |
GTEx: | Expressed in all |
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Protein evidence |
Evidence at protein level |
Protein localization |
Distinct granular cytoplasmic expression, mainly in the small intestine, hepatocytes and renal tubules. |
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ANTIBODY RELIABILITY
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Data reliability description
Standardized explanatory sentences with additional information required for full understanding of the
knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based
annotation, indicated by "Pending RNA-based expert annotation", when applicable.
Data reliability
Data reliability score ( score description), divided into supportive (premium)
or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several
antibodies with RNA-seq data and available gene/protein characterization data.
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Data reliability description |
Antibody staining consistent with RNA expression data. |
Data reliability |
Supportive based on 3 antibodies.
HPA051162
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HPA053502
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CAB018734
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PROTEIN EXPRESSION OVERVIEW
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Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting
of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a
selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in
detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation could not be performed, no protein
expression data is displayed in the protein expression data overview, however, all immunohistochemical images are
still available and the annotation data can be found under Primary data.
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GENE INFORMATION
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Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
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Gene name |
PCK2 (HGNC Symbol) |
Synonyms |
PEPCK, PEPCK2 |
Description |
Phosphoenolpyruvate carboxykinase 2 (mitochondrial) (HGNC Symbol) |
Entrez gene summary |
This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014] |
Chromosome |
14 |
Cytoband |
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Chromosome location (bp) |
24094053 - 24110598 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000100889 (version 78.38) |
Entrez gene |
5106 |
UniProt |
Q16822 (UniProt - Evidence at protein level) |
neXtProt |
NX_Q16822 |
Antibodypedia |
PCK2 antibodies |
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PROTEIN BROWSER
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The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The
tabs at the top of the protein view section can be used to switch between the different splice variants to which
an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green
bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is
displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues
(HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius (turquoise)
and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow
and InterPro regions in green. Common (purple) and
unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the
bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this
gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary
for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the
protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are
listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a
majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0 and
Phobius) and the number of predicted transmembrane region(s)
(according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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PCK2-001 |
ENSP00000380171
ENST00000396973
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H0YNG4 Show all »
« Hide
H0YNG4 [Target identity:25%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453998} H0YMU6 [Target identity:24%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453751}
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Show »
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Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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441 |
47.5 |
No |
0 |
PCK2-002 |
ENSP00000216780
ENST00000216780
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Q16822 Show all »
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Q16822 [Direct mapping]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial B4DW73 [Target identity:79%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000441826}; cDNA FLJ50710, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial {ECO:0000313|EMBL:BAG62935.1}; cDNA, FLJ79105, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial {ECO:0000313|EMBL:BAH14577.1} H0YNG4 [Target identity:17%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453998} H0YMU6 [Target identity:16%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453751}
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Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Mitochondrial proteins Citric acid cycle related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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640 |
70.7 |
No |
0 |
PCK2-003 |
ENSP00000453444
ENST00000559250
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H0YNG4 Show all »
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H0YNG4 [Target identity:22%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453998} H0YMU6 [Target identity:21%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453751}
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Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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509 |
54.6 |
No |
0 |
PCK2-005 |
ENSP00000454011
ENST00000561286
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B4DW73 Show all »
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B4DW73 [Target identity:100%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000441826}; cDNA FLJ50710, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial {ECO:0000313|EMBL:BAG62935.1}; cDNA, FLJ79105, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial {ECO:0000313|EMBL:BAH14577.1} H0YNG4 [Target identity:22%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453998} H0YMU6 [Target identity:21%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453751}
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Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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506 |
56 |
No |
0 |
PCK2-007 |
ENSP00000453656
ENST00000558096
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H0YML5 Show all »
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H0YML5 [Target identity:100%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453656} H0YNG4 [Target identity:23%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453998} H0YMU6 [Target identity:22%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453751}
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Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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474 |
52.5 |
No |
0 |
PCK2-008 |
ENSP00000441826
ENST00000545054
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B4DW73 Show all »
« Hide
B4DW73 [Target identity:100%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000441826}; cDNA FLJ50710, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial {ECO:0000313|EMBL:BAG62935.1}; cDNA, FLJ79105, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial {ECO:0000313|EMBL:BAH14577.1} H0YNG4 [Target identity:22%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453998} H0YMU6 [Target identity:21%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453751}
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Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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506 |
56 |
No |
0 |
PCK2-009 |
ENSP00000453791
ENST00000559171
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Show »
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Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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109 |
11.9 |
No |
0 |
PCK2-012 |
ENSP00000453998
ENST00000560736
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H0YNG4 Show all »
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H0YNG4 [Target identity:100%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453998} H0YMU6 [Target identity:94%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453751}
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Show »
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Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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113 |
12.3 |
No |
0 |
PCK2-013 |
ENSP00000453751
ENST00000559837
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H0YMU6 Show all »
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H0YMU6 [Target identity:100%; Query identity:100%]Phosphoenolpyruvate carboxykinase [GTP], mitochondrial {ECO:0000313|Ensembl:ENSP00000453751}
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Show »
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Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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107 |
11.5 |
No |
0 |
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