PSMB5

GENERAL INFORMATION

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Gene name

PSMB5

Gene description

Proteasome (prosome, macropain) subunit, beta type, 5

Protein class

Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Endocrine tissues, glomeruli of kidney, cells in seminiferus ducts of testis, glandular cells of breast, cells in CNS, endothelial cells, subsets of leukocytes, heart and smooth muscle showed moderate to strong nuclear positivity. Remaining normal tissues were in general negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA049518
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PSMB5 (HGNC Symbol)

Synonyms

MB1, X

Description

Proteasome (prosome, macropain) subunit, beta type, 5 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

23016543 - 23035230

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100804 (version 78.38)

Entrez gene

5693

UniProt

P28074 (UniProt - Evidence at protein level)

neXtProt

NX_P28074

Antibodypedia

PSMB5 antibodies


PROTEIN BROWSER

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ENST00000361611
 
ENST00000425762
 
ENST00000460922
 
ENST00000493471
 
ENST00000555895
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMB5-001 ENSP00000451286
ENST00000460922
G3V3K3
Show all »
Show » 84 8.6 No 0
PSMB5-002 ENSP00000355325
ENST00000361611
P28074
Show all »
Show » Show » 263 28.5 No 0
PSMB5-004 ENSP00000452424
ENST00000493471
P28074
Show all »
Show » Show » 203 21.8 No 0
PSMB5-005 ENSP00000395206
ENST00000425762
P28074
Show all »
Show » Show » 160 17.8 No 0
PSMB5-007 ENSP00000451816
ENST00000555895
Show » Show » 118 12.7 No 0