GZMB

GENE INFORMATION

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Gene name

GZMB (HGNC Symbol)

Synonyms

CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT

Description

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (HGNC Symbol)

Entrez gene summary

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q12

Chromosome location (bp)

24630954 - 24634267

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100453 (version 78.38)

Entrez gene

3002

UniProt

P10144 (UniProt - Evidence at protein level)

neXtProt

NX_P10144

Antibodypedia

GZMB antibodies
 

PROTEIN VIEW

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GZMB-001
 
GZMB-003
 
GZMB-005
 
GZMB-201
 
GZMB-202
 
GZMB-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GZMB-001 ENSP00000216341
ENST00000216341
P10144
Show all »
Show » Show » 247 27.7 Yes 0
GZMB-003 ENSP00000387385
ENST00000415355
J3KQ52
Show all »
Show » Show » 235 26.4 No 0
GZMB-005 ENSP00000434213
ENST00000526004
E9PRD7
Show all »
Show » Show » 90 10.2 Yes 0
GZMB-201 ENSP00000371980
ENST00000382540
E7EUV0
Show all »
Show » Show » 202 22.7 Yes 0
GZMB-202 ENSP00000371982
ENST00000382542
E7EUV0
Show all »
Show » Show » 202 22.7 Yes 0
GZMB-203 ENSP00000479643
ENST00000616551
Q6XGZ2
Show all »
Show » Show » 152 17 Yes 0