MYH9

GENERAL INFORMATION

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Gene name

MYH9

Gene description

Myosin, heavy chain 9, non-muscle

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous expression in several tissues. Distinct expression in renal glomeruli.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA001644 , CAB015386
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MYH9 (HGNC Symbol)

Synonyms

DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA

Description

Myosin, heavy chain 9, non-muscle (HGNC Symbol)

Entrez gene summary

This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]

Chromosome

22

Cytoband

q12.3

Chromosome location (bp)

36281281 - 36388018

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100345 (version 78.38)

Entrez gene

4627

UniProt

P35579 (UniProt - Evidence at protein level)

neXtProt

NX_P35579

Antibodypedia

MYH9 antibodies


PROTEIN BROWSER

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ENST00000216181
 
ENST00000401701
 
ENST00000456729
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYH9-001 ENSP00000216181
ENST00000216181
P35579
Show all »
Show » Show » 1960 226.5 No 0
MYH9-002 ENSP00000384631
ENST00000401701
Q5BKV1
Show all »
Show » Show » 218 24.8 No 0
MYH9-015 ENSP00000414852
ENST00000456729
B1AH99
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Show » Show » 103 11.6 No 0