POLR2F - Gene info - The Human Protein Atlas

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POLR2F

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TISSUE

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SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	POLR2F (HGNC Symbol)
Synonyms	HRBP14.4, RPB6
Description	Polymerase (RNA) II (DNA directed) polypeptide F (HGNC Symbol)
Entrez gene summary	This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	37952607 - 38041915
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100142 (version 78.38)
Entrez gene	5435
UniProt	P61218 (UniProt - Evidence at protein level)
neXtProt	NX_P61218
Antibodypedia	POLR2F antibodies

PROTEIN VIEW

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POLR2F-001		POLR2F-002		POLR2F-004		POLR2F-006		POLR2F-007		POLR2F-009		POLR2F-010		POLR2F-011		POLR2F-012		POLR2F-013

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
POLR2F-001	ENSP00000403852 ENST00000442738	P61218 Show all » « Hide P61218 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 U3KQS8 [Target identity:77%; Query identity:100%] DNA-directed RNA polymerases I, II, and III subunit RPABC2 {ECO:0000313\|Ensembl:ENSP00000476187}	Show » « Hide Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0000398 [mRNA splicing, via spliceosome] GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005730 [nucleolus] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006351 [transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006370 [7-methylguanosine mRNA capping] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0032481 [positive regulation of type I interferon production] GO:0045087 [innate immune response] GO:0050434 [positive regulation of viral transcription]	127	14.5	No	0
POLR2F-002	ENSP00000475257 ENST00000460648	U3KPV3 Show all » « Hide U3KPV3 [Target identity:100%; Query identity:100%] DNA-directed RNA polymerases I, II, and III subunit RPABC2 {ECO:0000313\|Ensembl:ENSP00000475257}	Show » « Hide Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0006351 [transcription, DNA-templated]	74	8.1	No	0
POLR2F-004	ENSP00000475342 ENST00000488684	U3KQQ7 Show all » « Hide U3KQQ7 [Target identity:100%; Query identity:100%] DNA-directed RNA polymerases I, II, and III subunit RPABC2 {ECO:0000313\|Ensembl:ENSP00000476132}	Show » « Hide Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014)		76	8.4	No	0
POLR2F-006	ENSP00000475343 ENST00000492213	U3KPY1 Show all » « Hide U3KPY1 [Target identity:100%; Query identity:100%] DNA-directed RNA polymerases I, II, and III subunit RPABC2 {ECO:0000313\|Ensembl:ENSP00000475343}	Show » « Hide Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated]	112	12.7	No	0
POLR2F-007	ENSP00000475707 ENST00000470701	U3KQB0 Show all » « Hide U3KQB0 [Target identity:100%; Query identity:100%] DNA-directed RNA polymerases I, II, and III subunit RPABC2 {ECO:0000313\|Ensembl:ENSP00000475707}	Show » « Hide Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated]	122	13.9	No	0
POLR2F-009	ENSP00000385725 ENST00000407936	B0QYL9 Show all » « Hide B0QYL9 [Target identity:100%; Query identity:100%] DNA-directed RNA polymerases I, II, and III subunit RPABC2 {ECO:0000313\|Ensembl:ENSP00000385725}	Show » « Hide Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0006351 [transcription, DNA-templated]	158	17.6	No	0
POLR2F-010	ENSP00000384112 ENST00000405557	B0QYL8 Show all » « Hide B0QYL8 [Target identity:100%; Query identity:100%] DNA-directed RNA polymerases I, II, and III subunit RPABC2 {ECO:0000313\|Ensembl:ENSP00000384112} U3KQS8 [Target identity:77%; Query identity:100%] DNA-directed RNA polymerases I, II, and III subunit RPABC2 {ECO:0000313\|Ensembl:ENSP00000476187}	Show » « Hide Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0006351 [transcription, DNA-templated]	126	14.2	No	0
POLR2F-011	ENSP00000332130 ENST00000333418		Show » « Hide Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014)		145	15.1	No	0
POLR2F-012	ENSP00000389307 ENST00000427034		Show » « Hide Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014)		93	9.7	No	0
POLR2F-013	ENSP00000476187 ENST00000606538	U3KQS8 Show all » « Hide U3KQS8 [Target identity:100%; Query identity:100%] DNA-directed RNA polymerases I, II, and III subunit RPABC2 {ECO:0000313\|Ensembl:ENSP00000476187}	Show » « Hide Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0006351 [transcription, DNA-templated]	98	11.1	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.