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GENERAL INFORMATION
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Protein class
Protein class the gene product belongs to according to selected gene lists. List of protein classes.
Predicted localization
Protein localization predicted from several bioinformatic algorithms. More info...
Number of transcripts
Number of protein-coding transcribed from this gene as defined by Ensembl.
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Gene name |
MKNK2 |
Gene description |
MAP kinase interacting serine/threonine kinase 2 |
Protein class |
Enzymes Predicted intracellular proteins |
Predicted localization |
Intracellular |
Number of transcripts |
8 |
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HUMAN PROTEIN ATLAS INFORMATION
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RNA tissue category
The RNA tissue category is based on mRNA expression levels in 32 different tissues ( RNA assay description).
The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, not detected, and mixed.
RNA tissue category is calculated separately both for internally generated Human Protein Atlas (HPA) RNA-seq data, as
well as RNA-seq data from the Genotype-Tissue Expression ( GTEx) consortium.
Protein evidence
Protein evidence scores are generated from several independent sources
and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence or iv) not available.
Protein localization
A summary of the overall protein expression pattern across the analyzed tissues. The summary is based on knowledge-based
annotation ( Annotation description). For genes pending
knowledge-based annotation, the protein localization refers to the antibody staining pattern.
"RNA-based expert annotation gave inconconclusive results" is shown for genes analyzed with a knowledge-based approach where
available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with
immunohistochemistry-data to yield a reliable estimation of the protein expression profile.
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RNA tissue category |
HPA: | Expressed in all |
GTEx: | Expressed in all |
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Protein evidence |
Evidence at protein level |
Protein localization |
General cytoplasmic and nuclear expression. |
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ANTIBODY RELIABILITY
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Data reliability description
Standardized explanatory sentences with additional information required for full understanding of the
knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based
annotation, indicated by "Pending RNA-based expert annotation", when applicable.
Data reliability
Data reliability score ( score description), divided into supportive (premium)
or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several
antibodies with RNA-seq data and available gene/protein characterization data.
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Data reliability description |
Pending RNA-based expert annotation. |
Data reliability |
Supportive based on 2 antibodies.
HPA021875
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CAB037253
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PROTEIN EXPRESSION OVERVIEW
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Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting
of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a
selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in
detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation could not be performed, no protein
expression data is displayed in the protein expression data overview, however, all immunohistochemical images are
still available and the annotation data can be found under Primary data.
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GENE INFORMATION
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Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
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Gene name |
MKNK2 (HGNC Symbol) |
Synonyms |
GPRK7, MNK2 |
Description |
MAP kinase interacting serine/threonine kinase 2 (HGNC Symbol) |
Entrez gene summary |
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011] |
Chromosome |
19 |
Cytoband |
p13.3 |
Chromosome location (bp) |
2037465 - 2051244 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000099875 (version 78.38) |
Entrez gene |
2872 |
UniProt |
Q9HBH9 (UniProt - Evidence at protein level) |
neXtProt |
NX_Q9HBH9 |
Antibodypedia |
MKNK2 antibodies |
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PROTEIN BROWSER
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The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The
tabs at the top of the protein view section can be used to switch between the different splice variants to which
an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green
bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is
displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues
(HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius (turquoise)
and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow
and InterPro regions in green. Common (purple) and
unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the
bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this
gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary
for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the
protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are
listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a
majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0 and
Phobius) and the number of predicted transmembrane region(s)
(according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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MKNK2-001 |
ENSP00000309485
ENST00000309340
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Q9NT28 Show all »
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Q9NT28 [Target identity:76%; Query identity:100%]Putative uncharacterized protein DKFZp586A1021 {ECO:0000313|EMBL:CAB70816.1} Q9NV89 [Target identity:38%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000465645}; MKNK2 protein {ECO:0000313|EMBL:AAH18345.1}; cDNA FLJ10868 fis, clone NT2RP4001644, weakly similar to MYOSIN LIGHT CHAIN KINASE {ECO:0000313|EMBL:BAA91866.1} K7EIN7 [Target identity:31%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000464828} K7EJ98 [Target identity:31%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000465079}
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MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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414 |
46.7 |
No |
0 |
MKNK2-004 |
ENSP00000467811
ENST00000591601
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Q9HBH9 Show all »
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Q9HBH9 [Target identity:100%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 A4CYL7 [Target identity:100%; Query identity:98%]Putative map kinase interacting kinase [Homo sapiens] {ECO:0000313|EMBL:AAD21217.1} B4DEQ4 [Target identity:71%; Query identity:100%]cDNA FLJ53467, highly similar to MAP kinase-interactingserine/threonine-protein kinase 2 {ECO:0000313|EMBL:BAG57165.1} B3KS07 [Target identity:32%; Query identity:100%]cDNA FLJ35217 fis, clone PROST2000284, highly similar to MAP kinase-interactingserine/threonine-protein kinase 2 {ECO:0000313|EMBL:BAG52569.1} K7EIN7 [Target identity:27%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000464828} K7EJ98 [Target identity:27%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000465079}
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Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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465 |
51.9 |
No |
0 |
MKNK2-005 |
ENSP00000465645
ENST00000591142
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Q9NV89 Show all »
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Q9NV89 [Target identity:100%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000465645}; MKNK2 protein {ECO:0000313|EMBL:AAH18345.1}; cDNA FLJ10868 fis, clone NT2RP4001644, weakly similar to MYOSIN LIGHT CHAIN KINASE {ECO:0000313|EMBL:BAA91866.1} K7EIN7 [Target identity:81%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000464828} K7EJ98 [Target identity:81%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000465079}
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MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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158 |
17.7 |
No |
0 |
MKNK2-006 |
ENSP00000466147
ENST00000589509
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K7ELN0 Show all »
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K7ELN0 [Target identity:90%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000466147}
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Show »
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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76 |
8.2 |
No |
0 |
MKNK2-009 |
ENSP00000464828
ENST00000591588
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K7EIN7 Show all »
« Hide
K7EIN7 [Target identity:100%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000464828} K7EJ98 [Target identity:100%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000465079}
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Show »
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MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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129 |
14.4 |
No |
0 |
MKNK2-010 |
ENSP00000465079
ENST00000588014
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K7EIN7 Show all »
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K7EIN7 [Target identity:73%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000464828} K7EJ98 [Target identity:73%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000465079}
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MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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176 |
19.4 |
No |
0 |
MKNK2-012 |
ENSP00000466064
ENST00000589534
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K7ELN0 Show all »
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K7ELN0 [Target identity:93%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000466147}
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Show »
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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74 |
8 |
No |
0 |
MKNK2-201 |
ENSP00000250896
ENST00000250896
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Q9HBH9 Show all »
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Q9HBH9 [Target identity:100%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 A4CYL7 [Target identity:100%; Query identity:98%]Putative map kinase interacting kinase [Homo sapiens] {ECO:0000313|EMBL:AAD21217.1} B4DEQ4 [Target identity:71%; Query identity:100%]cDNA FLJ53467, highly similar to MAP kinase-interactingserine/threonine-protein kinase 2 {ECO:0000313|EMBL:BAG57165.1} B3KS07 [Target identity:32%; Query identity:100%]cDNA FLJ35217 fis, clone PROST2000284, highly similar to MAP kinase-interactingserine/threonine-protein kinase 2 {ECO:0000313|EMBL:BAG52569.1} K7EIN7 [Target identity:27%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000464828} K7EJ98 [Target identity:27%; Query identity:100%]MAP kinase-interacting serine/threonine-protein kinase 2 {ECO:0000313|Ensembl:ENSP00000465079}
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Show »
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Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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465 |
51.9 |
No |
0 |
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