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GENERAL INFORMATION
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Protein class
Protein class the gene product belongs to according to selected gene lists. List of protein classes.
Predicted localization
Protein localization predicted from several bioinformatic algorithms. More info...
Number of transcripts
Number of protein-coding transcribed from this gene as defined by Ensembl.
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Gene name |
ESR1 |
Gene description |
Estrogen receptor 1 |
Protein class |
Cancer-related genes
Disease related genes
FDA approved drug targets
Nuclear receptors
Predicted intracellular proteins
Transcription factors |
Predicted localization |
Intracellular |
Number of transcripts |
10 |
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HUMAN PROTEIN ATLAS INFORMATION
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RNA tissue category
The RNA tissue category is based on mRNA expression levels in 32 different tissues ( RNA assay description).
The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, not detected, and mixed.
RNA tissue category is calculated separately both for internally generated Human Protein Atlas (HPA) RNA-seq data, as
well as RNA-seq data from the Genotype-Tissue Expression ( GTEx) consortium.
Protein evidence
Protein evidence scores are generated from several independent sources
and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence or iv) not available.
Protein localization
A summary of the overall protein expression pattern across the analyzed tissues. The summary is based on knowledge-based
annotation ( Annotation description). For genes pending
knowledge-based annotation, the protein localization refers to the antibody staining pattern.
"RNA-based expert annotation gave inconconclusive results" is shown for genes analyzed with a knowledge-based approach where
available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with
immunohistochemistry-data to yield a reliable estimation of the protein expression profile.
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RNA tissue category |
| HPA: | Group enriched (endometrium, fallopian tube, smooth muscle) |
| GTEx: | Group enriched (breast, cervix, uterine, endometrium, fallopian tube, vagina) |
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Protein evidence |
Evidence at protein level |
Protein localization |
Selective nuclear expression in female genitalia. |
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ANTIBODY RELIABILITY
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Data reliability description
Standardized explanatory sentences with additional information required for full understanding of the
knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based
annotation, indicated by "Pending RNA-based expert annotation", when applicable.
Data reliability
Data reliability score ( score description), divided into supportive (premium)
or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several
antibodies with RNA-seq data and available gene/protein characterization data.
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Data reliability
description |
Antibody staining consistent with RNA expression data. |
Data reliability |
Supportive based on 5 antibodies.
HPA000449
,
HPA000450
,
CAB000037
,
CAB055099
,
CAB072858
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PROTEIN EXPRESSION OVERVIEW
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Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting
of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a
selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in
detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation could not be performed, no protein
expression data is displayed in the protein expression data overview, however, all immunohistochemical images are
still available and the annotation data can be found under Primary data.
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GENE INFORMATION
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Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
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Gene name |
ESR1 (HGNC Symbol) |
Synonyms |
Era, ESR, NR3A1 |
Description |
Estrogen receptor 1 (HGNC Symbol) |
Entrez gene summary |
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014] |
Chromosome |
6 |
Cytoband |
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Chromosome location (bp) |
151656691 - 152129619 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000091831 (version 78.38) |
Entrez gene |
2099 |
UniProt |
P03372 (UniProt - Evidence at protein level) |
neXtProt |
NX_P03372 |
Antibodypedia |
ESR1 antibodies |
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PROTEIN BROWSER
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The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The
tabs at the top of the protein view section can be used to switch between the different splice variants to which
an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green
bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is
displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues
(HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius (turquoise)
and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow
and InterPro regions in green. Common (purple) and
unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the
bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this
gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary
for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the
protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are
listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a
majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0 and
Phobius) and the number of predicted transmembrane region(s)
(according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length
(aa) |
Molecular mass
(kDa) |
Signal peptide
(predicted) |
Transmembrane regions
(predicted)
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| ESR1-001 |
ENSP00000206249
ENST00000206249
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P03372
Show all »
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P03372 [Direct mapping]Estrogen receptor G4XH65 [Target identity:100%; Query identity:100%]Estrogen receptor {ECO:0000256|PIRNR:PIRNR002527} K4PXX0 [Target identity:32%; Query identity:100%]Estrogen receptor alpha E1-1-2 variant {ECO:0000313|EMBL:BAM62930.1}; Estrogen receptor alpha E1-E2-1-2 variant {ECO:0000313|EMBL:BAM62931.1}; Estrogen receptor alpha E1-N2-E2-1-2 variant {ECO:0000313|EMBL:BAM62933.1} E3WH18 [Target identity:31%; Query identity:100%]Estrogen receptor alpha {ECO:0000313|EMBL:BAJ41265.1} Q9UE35 [Target identity:19%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000411105}; Estrogen receptor protein {ECO:0000313|EMBL:CAA44322.1} K7R989 [Target identity:17%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AGC74339.1}; Estrogen receptor protein {ECO:0000313|EMBL:AFV77694.1} Q5T5H8 [Target identity:14%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000385373} K4PX46 [Target identity:9%; Query identity:100%]Estrogen receptor alpha E1-N1-E2-1 variant {ECO:0000313|EMBL:BAM62932.1} B6DU67 [Target identity:7%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform {ECO:0000313|EMBL:ACI04256.1} C7FFR5 [Target identity:7%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform {ECO:0000313|EMBL:ACU29456.1} C8CJL0 [Target identity:4%; Query identity:100%]Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform {ECO:0000313|EMBL:ACV41787.1} K4Q331 [Target identity:3%; Query identity:100%]Estrogen receptor alpha E1-2 variant {ECO:0000313|EMBL:BAM62934.1}; Estrogen receptor alpha E1-E2-2 variant {ECO:0000313|EMBL:BAM62935.1}; Estrogen receptor alpha E1-N2-E2-2 variant {ECO:0000313|EMBL:BAM62936.1} Q9UBT1 [Target identity:3%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AAC51875.1}
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Nuclear receptors
THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains
Cancer-related genes
Candidate cancer biomarkers
Mutational cancer driver genes
Disease related genes
FDA approved drug targets
Small molecule drugs
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010629 [negative regulation of gene expression] GO:0010863 [positive regulation of phospholipase C activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030284 [estrogen receptor activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0032355 [response to estradiol] GO:0034056 [estrogen response element binding] GO:0035327 [transcriptionally active chromatin] GO:0038052 [estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0042802 [identical protein binding] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048386 [positive regulation of retinoic acid receptor signaling pathway] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0071392 [cellular response to estradiol stimulus]
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595 |
66.2 |
No |
0 |
| ESR1-002 |
ENSP00000342630
ENST00000338799
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P03372
Show all »
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P03372 [Direct mapping]Estrogen receptor G4XH65 [Target identity:100%; Query identity:100%]Estrogen receptor {ECO:0000256|PIRNR:PIRNR002527} K4PXX0 [Target identity:32%; Query identity:100%]Estrogen receptor alpha E1-1-2 variant {ECO:0000313|EMBL:BAM62930.1}; Estrogen receptor alpha E1-E2-1-2 variant {ECO:0000313|EMBL:BAM62931.1}; Estrogen receptor alpha E1-N2-E2-1-2 variant {ECO:0000313|EMBL:BAM62933.1} E3WH18 [Target identity:31%; Query identity:100%]Estrogen receptor alpha {ECO:0000313|EMBL:BAJ41265.1} Q9UE35 [Target identity:19%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000411105}; Estrogen receptor protein {ECO:0000313|EMBL:CAA44322.1} K7R989 [Target identity:17%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AGC74339.1}; Estrogen receptor protein {ECO:0000313|EMBL:AFV77694.1} Q5T5H8 [Target identity:14%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000385373} K4PX46 [Target identity:9%; Query identity:100%]Estrogen receptor alpha E1-N1-E2-1 variant {ECO:0000313|EMBL:BAM62932.1} B6DU67 [Target identity:7%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform {ECO:0000313|EMBL:ACI04256.1} C7FFR5 [Target identity:7%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform {ECO:0000313|EMBL:ACU29456.1} C8CJL0 [Target identity:4%; Query identity:100%]Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform {ECO:0000313|EMBL:ACV41787.1} K4Q331 [Target identity:3%; Query identity:100%]Estrogen receptor alpha E1-2 variant {ECO:0000313|EMBL:BAM62934.1}; Estrogen receptor alpha E1-E2-2 variant {ECO:0000313|EMBL:BAM62935.1}; Estrogen receptor alpha E1-N2-E2-2 variant {ECO:0000313|EMBL:BAM62936.1} Q9UBT1 [Target identity:3%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AAC51875.1}
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Nuclear receptors
THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains
Cancer-related genes
Candidate cancer biomarkers
Mutational cancer driver genes
Disease related genes
FDA approved drug targets
Small molecule drugs
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010629 [negative regulation of gene expression] GO:0010863 [positive regulation of phospholipase C activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030284 [estrogen receptor activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0032355 [response to estradiol] GO:0034056 [estrogen response element binding] GO:0035327 [transcriptionally active chromatin] GO:0038052 [estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0042802 [identical protein binding] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048386 [positive regulation of retinoic acid receptor signaling pathway] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0071392 [cellular response to estradiol stimulus]
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595 |
66.2 |
No |
0 |
| ESR1-004 |
ENSP00000385373
ENST00000404742
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Q5T5H8
Show all »
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Q5T5H8 [Target identity:100%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000385373} K4PX46 [Target identity:69%; Query identity:100%]Estrogen receptor alpha E1-N1-E2-1 variant {ECO:0000313|EMBL:BAM62932.1} Q9UBT1 [Target identity:27%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AAC51875.1}
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Nuclear receptors
Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
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84 |
9 |
No |
0 |
| ESR1-007 |
ENSP00000411105
ENST00000446550
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Q9UE35
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Q9UE35 [Target identity:100%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000411105}; Estrogen receptor protein {ECO:0000313|EMBL:CAA44322.1} K7R989 [Target identity:88%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AGC74339.1}; Estrogen receptor protein {ECO:0000313|EMBL:AFV77694.1} Q5T5H8 [Target identity:73%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000385373} K4PX46 [Target identity:50%; Query identity:100%]Estrogen receptor alpha E1-N1-E2-1 variant {ECO:0000313|EMBL:BAM62932.1} Q9UBT1 [Target identity:20%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AAC51875.1}
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Nuclear receptors
Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
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115 |
12.1 |
No |
0 |
| ESR1-008 |
ENSP00000394721
ENST00000427531
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H0Y4W6
Show all »
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H0Y4W6 [Target identity:100%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000394721} C7FFR5 [Target identity:14%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform {ECO:0000313|EMBL:ACU29456.1} B6DU67 [Target identity:13%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform {ECO:0000313|EMBL:ACI04256.1} K4Q331 [Target identity:6%; Query identity:100%]Estrogen receptor alpha E1-2 variant {ECO:0000313|EMBL:BAM62934.1}; Estrogen receptor alpha E1-E2-2 variant {ECO:0000313|EMBL:BAM62935.1}; Estrogen receptor alpha E1-N2-E2-2 variant {ECO:0000313|EMBL:BAM62936.1}
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THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
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310 |
35.3 |
No |
0 |
| ESR1-009 |
ENSP00000384064
ENST00000406599
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Q9H2M1
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Q9H2M1 [Target identity:100%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000384064}; Estrogen receptor alpha {ECO:0000313|EMBL:AAG41359.1} Q9UE35 [Target identity:34%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000411105}; Estrogen receptor protein {ECO:0000313|EMBL:CAA44322.1} K7R989 [Target identity:30%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AGC74339.1}; Estrogen receptor protein {ECO:0000313|EMBL:AFV77694.1} Q5T5H8 [Target identity:25%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000385373} K4PX46 [Target identity:17%; Query identity:100%]Estrogen receptor alpha E1-N1-E2-1 variant {ECO:0000313|EMBL:BAM62932.1} Q9UBT1 [Target identity:6%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AAC51875.1}
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Nuclear receptors
Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
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334 |
36.7 |
No |
0 |
| ESR1-010 |
ENSP00000401995
ENST00000415488
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B0QYW7
Show all »
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B0QYW7 [Target identity:100%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000401995}
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SCAMPI predicted membrane proteins
THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
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107 |
12.3 |
No |
0 |
| ESR1-201 |
ENSP00000405330
ENST00000440973
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P03372
Show all »
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P03372 [Direct mapping]Estrogen receptor G4XH65 [Target identity:100%; Query identity:100%]Estrogen receptor {ECO:0000256|PIRNR:PIRNR002527} K4PXX0 [Target identity:32%; Query identity:100%]Estrogen receptor alpha E1-1-2 variant {ECO:0000313|EMBL:BAM62930.1}; Estrogen receptor alpha E1-E2-1-2 variant {ECO:0000313|EMBL:BAM62931.1}; Estrogen receptor alpha E1-N2-E2-1-2 variant {ECO:0000313|EMBL:BAM62933.1} E3WH18 [Target identity:31%; Query identity:100%]Estrogen receptor alpha {ECO:0000313|EMBL:BAJ41265.1} Q9UE35 [Target identity:19%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000411105}; Estrogen receptor protein {ECO:0000313|EMBL:CAA44322.1} K7R989 [Target identity:17%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AGC74339.1}; Estrogen receptor protein {ECO:0000313|EMBL:AFV77694.1} Q5T5H8 [Target identity:14%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000385373} K4PX46 [Target identity:9%; Query identity:100%]Estrogen receptor alpha E1-N1-E2-1 variant {ECO:0000313|EMBL:BAM62932.1} B6DU67 [Target identity:7%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform {ECO:0000313|EMBL:ACI04256.1} C7FFR5 [Target identity:7%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform {ECO:0000313|EMBL:ACU29456.1} C8CJL0 [Target identity:4%; Query identity:100%]Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform {ECO:0000313|EMBL:ACV41787.1} K4Q331 [Target identity:3%; Query identity:100%]Estrogen receptor alpha E1-2 variant {ECO:0000313|EMBL:BAM62934.1}; Estrogen receptor alpha E1-E2-2 variant {ECO:0000313|EMBL:BAM62935.1}; Estrogen receptor alpha E1-N2-E2-2 variant {ECO:0000313|EMBL:BAM62936.1} Q9UBT1 [Target identity:3%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AAC51875.1}
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Nuclear receptors
THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains
Cancer-related genes
Candidate cancer biomarkers
Mutational cancer driver genes
Disease related genes
FDA approved drug targets
Small molecule drugs
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001547 [antral ovarian follicle growth] GO:0002064 [epithelial cell development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008209 [androgen metabolic process] GO:0008270 [zinc ion binding] GO:0008584 [male gonad development] GO:0010467 [gene expression] GO:0010629 [negative regulation of gene expression] GO:0010863 [positive regulation of phospholipase C activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030284 [estrogen receptor activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0032355 [response to estradiol] GO:0034056 [estrogen response element binding] GO:0035327 [transcriptionally active chromatin] GO:0038052 [estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048386 [positive regulation of retinoic acid receptor signaling pathway] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060065 [uterus development] GO:0060068 [vagina development] GO:0060523 [prostate epithelial cord elongation] GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis] GO:0060687 [regulation of branching involved in prostate gland morphogenesis] GO:0060745 [mammary gland branching involved in pregnancy] GO:0060749 [mammary gland alveolus development] GO:0060750 [epithelial cell proliferation involved in mammary gland duct elongation] GO:0071391 [cellular response to estrogen stimulus] GO:0071392 [cellular response to estradiol stimulus]
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595 |
66.2 |
No |
0 |
| ESR1-202 |
ENSP00000387500
ENST00000443427
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P03372
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P03372 [Direct mapping]Estrogen receptor G4XH65 [Target identity:100%; Query identity:100%]Estrogen receptor {ECO:0000256|PIRNR:PIRNR002527} K4PXX0 [Target identity:32%; Query identity:100%]Estrogen receptor alpha E1-1-2 variant {ECO:0000313|EMBL:BAM62930.1}; Estrogen receptor alpha E1-E2-1-2 variant {ECO:0000313|EMBL:BAM62931.1}; Estrogen receptor alpha E1-N2-E2-1-2 variant {ECO:0000313|EMBL:BAM62933.1} E3WH18 [Target identity:31%; Query identity:100%]Estrogen receptor alpha {ECO:0000313|EMBL:BAJ41265.1} Q9UE35 [Target identity:19%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000411105}; Estrogen receptor protein {ECO:0000313|EMBL:CAA44322.1} K7R989 [Target identity:17%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AGC74339.1}; Estrogen receptor protein {ECO:0000313|EMBL:AFV77694.1} Q5T5H8 [Target identity:14%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000385373} K4PX46 [Target identity:9%; Query identity:100%]Estrogen receptor alpha E1-N1-E2-1 variant {ECO:0000313|EMBL:BAM62932.1} B6DU67 [Target identity:7%; Query identity:100%]Estrogen receptor alpha delta 3*,4,5,6,7*/775 hypothalamic isoform {ECO:0000313|EMBL:ACI04256.1} C7FFR5 [Target identity:7%; Query identity:100%]Estrogen receptor alpha 3*,4,5,6,7*/765 isoform {ECO:0000313|EMBL:ACU29456.1} C8CJL0 [Target identity:4%; Query identity:100%]Estrogen receptor alpha delta 2*,3,4,5,6,7 isoform {ECO:0000313|EMBL:ACV41787.1} K4Q331 [Target identity:3%; Query identity:100%]Estrogen receptor alpha E1-2 variant {ECO:0000313|EMBL:BAM62934.1}; Estrogen receptor alpha E1-E2-2 variant {ECO:0000313|EMBL:BAM62935.1}; Estrogen receptor alpha E1-N2-E2-2 variant {ECO:0000313|EMBL:BAM62936.1} Q9UBT1 [Target identity:3%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AAC51875.1}
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Nuclear receptors
THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains
Cancer-related genes
Candidate cancer biomarkers
Mutational cancer driver genes
Disease related genes
FDA approved drug targets
Small molecule drugs
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010629 [negative regulation of gene expression] GO:0010863 [positive regulation of phospholipase C activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030284 [estrogen receptor activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0032355 [response to estradiol] GO:0034056 [estrogen response element binding] GO:0035327 [transcriptionally active chromatin] GO:0038052 [estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0042802 [identical protein binding] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048386 [positive regulation of retinoic acid receptor signaling pathway] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0071392 [cellular response to estradiol stimulus]
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595 |
66.2 |
No |
0 |
| ESR1-203 |
ENSP00000415934
ENST00000456483
|
Q9H2M2
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Q9H2M2 [Target identity:100%; Query identity:100%]Estrogen receptor alpha {ECO:0000313|EMBL:AAG41358.1} Q9UE35 [Target identity:75%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000411105}; Estrogen receptor protein {ECO:0000313|EMBL:CAA44322.1} K7R989 [Target identity:67%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AGC74339.1}; Estrogen receptor protein {ECO:0000313|EMBL:AFV77694.1} Q5T5H8 [Target identity:55%; Query identity:100%]Estrogen receptor {ECO:0000313|Ensembl:ENSP00000385373} K4PX46 [Target identity:38%; Query identity:100%]Estrogen receptor alpha E1-N1-E2-1 variant {ECO:0000313|EMBL:BAM62932.1} Q9UBT1 [Target identity:15%; Query identity:100%]Estrogen receptor {ECO:0000313|EMBL:AAC51875.1}
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Nuclear receptors
Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
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152 |
16.3 |
No |
0 |
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