IRAK3

GENERAL INFORMATION

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Gene name

IRAK3

Gene description

Interleukin-1 receptor-associated kinase 3

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (bone marrow)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Normal tissues showed weak to moderate cytoplasmic staining, in several cases accompanied by membranous positivity. Gall bladder and salivary gland exhibited strong cytoplasmic and membranous positivity. Respiratory epithelia, lung macrophages, trophoblastic cells, thyroid, germinal center cells of tonsil and subsets of cells in adrenal glands displayed strong cytoplasmic immunoreactivity. Cells in seminiferus ducts, renal glomeruli, smooth muscle and glial cells were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA043097
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

IRAK3 (HGNC Symbol)

Synonyms

IRAK-M

Description

Interleukin-1 receptor-associated kinase 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Chromosome

12

Cytoband

q14.3

Chromosome location (bp)

66188879 - 66254622

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000090376 (version 78.38)

Entrez gene

11213

UniProt

Q9Y616 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y616

Antibodypedia

IRAK3 antibodies


PROTEIN BROWSER

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ENST00000261233
 
ENST00000457197
 
ENST00000545837
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IRAK3-001 ENSP00000261233
ENST00000261233
Q9Y616
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Show » Show » 596 67.8 No 0
IRAK3-002 ENSP00000441321
ENST00000545837
F5GYN6
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Show » 93 10 Yes 0
IRAK3-003 ENSP00000409852
ENST00000457197
Q9Y616
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Show » Show » 535 60.6 Yes 0