Tissue expression of NOX4 - Summary - The Human Protein Atlas

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NOX4

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	NOX4
Gene description	NADPH oxidase 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Tissue enriched (kidney)
GTEx:	Tissue enhanced (kidney)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in kidney.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Data reliability	Uncertain based on 1 antibody. HPA015475
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Tissue enriched (kidney)

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enhanced (kidney)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	NOX4 (HGNC Symbol)
Synonyms	KOX, KOX-1
Description	NADPH oxidase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Chromosome	11
Cytoband	q14.3
Chromosome location (bp)	89324356 - 89498187
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000086991 (version 78.38)
Entrez gene	50507
UniProt	Q9NPH5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPH5
Antibodypedia	NOX4 antibodies

PROTEIN BROWSER

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ENST00000263317		ENST00000343727		ENST00000375979		ENST00000393282		ENST00000424319		ENST00000525196		ENST00000527626		ENST00000527956		ENST00000528341		ENST00000531342		ENST00000532825		ENST00000534731

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
NOX4-001	ENSP00000263317 ENST00000263317	Q9NPH5 Show all » « Hide Q9NPH5 [Direct mapping] NADPH oxidase 4	Show » « Hide Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM	Show » « Hide GO:0000166 [nucleotide binding] GO:0000902 [cell morphogenesis] GO:0001666 [response to hypoxia] GO:0001725 [stress fiber] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005925 [focal adhesion] GO:0006801 [superoxide metabolic process] GO:0006954 [inflammatory response] GO:0007568 [aging] GO:0007569 [cell aging] GO:0008285 [negative regulation of cell proliferation] GO:0009055 [electron carrier activity] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016175 [superoxide-generating NADPH oxidase activity] GO:0016324 [apical plasma membrane] GO:0016491 [oxidoreductase activity] GO:0019826 [oxygen sensor activity] GO:0020037 [heme binding] GO:0042554 [superoxide anion generation] GO:0043020 [NADPH oxidase complex] GO:0043065 [positive regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0045453 [bone resorption] GO:0048471 [perinuclear region of cytoplasm] GO:0050660 [flavin adenine dinucleotide binding] GO:0050664 [oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor] GO:0050667 [homocysteine metabolic process] GO:0051496 [positive regulation of stress fiber assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055007 [cardiac muscle cell differentiation] GO:0055114 [oxidation-reduction process] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071320 [cellular response to cAMP] GO:0071333 [cellular response to glucose stimulus] GO:0071480 [cellular response to gamma radiation] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0071944 [cell periphery] GO:0072341 [modified amino acid binding] GO:0072593 [reactive oxygen species metabolic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2000573 [positive regulation of DNA biosynthetic process]	578	66.9	No	7
NOX4-002	ENSP00000433797 ENST00000527956	Q9NPH5 Show all » « Hide Q9NPH5 [Direct mapping] NADPH oxidase 4	Show » « Hide Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM	Show » « Hide GO:0000166 [nucleotide binding] GO:0000902 [cell morphogenesis] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0006954 [inflammatory response] GO:0007569 [cell aging] GO:0008285 [negative regulation of cell proliferation] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016491 [oxidoreductase activity] GO:0019826 [oxygen sensor activity] GO:0020037 [heme binding] GO:0042554 [superoxide anion generation] GO:0050660 [flavin adenine dinucleotide binding] GO:0050667 [homocysteine metabolic process] GO:0055114 [oxidation-reduction process] GO:0072341 [modified amino acid binding] GO:0072593 [reactive oxygen species metabolic process]	554	64.1	No	6
NOX4-003	ENSP00000376961 ENST00000393282	Q9NPH5 Show all » « Hide Q9NPH5 [Direct mapping] NADPH oxidase 4	Show » « Hide Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM	Show » « Hide GO:0000166 [nucleotide binding] GO:0000902 [cell morphogenesis] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0006954 [inflammatory response] GO:0007569 [cell aging] GO:0008285 [negative regulation of cell proliferation] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0019826 [oxygen sensor activity] GO:0020037 [heme binding] GO:0042554 [superoxide anion generation] GO:0050660 [flavin adenine dinucleotide binding] GO:0050667 [homocysteine metabolic process] GO:0055114 [oxidation-reduction process] GO:0072341 [modified amino acid binding] GO:0072593 [reactive oxygen species metabolic process]	54	6.5	No	1
NOX4-004	ENSP00000434924 ENST00000532825	Q9NPH5 Show all » « Hide Q9NPH5 [Direct mapping] NADPH oxidase 4	Show » « Hide Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM	Show » « Hide GO:0000166 [nucleotide binding] GO:0000902 [cell morphogenesis] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0006954 [inflammatory response] GO:0007569 [cell aging] GO:0008285 [negative regulation of cell proliferation] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016491 [oxidoreductase activity] GO:0019826 [oxygen sensor activity] GO:0020037 [heme binding] GO:0042554 [superoxide anion generation] GO:0050660 [flavin adenine dinucleotide binding] GO:0050667 [homocysteine metabolic process] GO:0055114 [oxidation-reduction process] GO:0072341 [modified amino acid binding] GO:0072593 [reactive oxygen species metabolic process]	514	59.9	No	5
NOX4-005	ENSP00000344747 ENST00000343727	Q9NPH5 Show all » « Hide Q9NPH5 [Direct mapping] NADPH oxidase 4	Show » « Hide Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM	Show » « Hide GO:0000166 [nucleotide binding] GO:0000902 [cell morphogenesis] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0006954 [inflammatory response] GO:0007569 [cell aging] GO:0008285 [negative regulation of cell proliferation] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016491 [oxidoreductase activity] GO:0019826 [oxygen sensor activity] GO:0020037 [heme binding] GO:0042554 [superoxide anion generation] GO:0050660 [flavin adenine dinucleotide binding] GO:0050667 [homocysteine metabolic process] GO:0055114 [oxidation-reduction process] GO:0072341 [modified amino acid binding] GO:0072593 [reactive oxygen species metabolic process]	554	64.1	No	6
NOX4-006	ENSP00000436970 ENST00000528341	E9PPP2 Show all » « Hide E9PPP2 [Target identity:100%; Query identity:100%] NADPH oxidase 4 {ECO:0000313\|Ensembl:ENSP00000436970}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM	Show » « Hide GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process]	553	63.5	No	6
NOX4-007	ENSP00000436093 ENST00000527626	E9PR43 Show all » « Hide E9PR43 [Target identity:100%; Query identity:100%] NADPH oxidase 4 {ECO:0000313\|Ensembl:ENSP00000436093}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM	Show » « Hide GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process]	391	45.5	Yes	3
NOX4-008	ENSP00000436716 ENST00000525196	E9PI95 Show all » « Hide E9PI95 [Target identity:100%; Query identity:100%] NADPH oxidase 4 {ECO:0000313\|Ensembl:ENSP00000436716}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM	Show » « Hide GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process]	342	40.1	No	5
NOX4-009	ENSP00000365146 ENST00000375979	Q9NPH5 Show all » « Hide Q9NPH5 [Direct mapping] NADPH oxidase 4	Show » « Hide Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM	Show » « Hide GO:0000166 [nucleotide binding] GO:0000902 [cell morphogenesis] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0006954 [inflammatory response] GO:0007569 [cell aging] GO:0008285 [negative regulation of cell proliferation] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016491 [oxidoreductase activity] GO:0019826 [oxygen sensor activity] GO:0020037 [heme binding] GO:0042554 [superoxide anion generation] GO:0050660 [flavin adenine dinucleotide binding] GO:0050667 [homocysteine metabolic process] GO:0055114 [oxidation-reduction process] GO:0072341 [modified amino acid binding] GO:0072593 [reactive oxygen species metabolic process]	271	31.8	No	2
NOX4-010	ENSP00000435039 ENST00000531342	Q9NPH5 Show all » « Hide Q9NPH5 [Direct mapping] NADPH oxidase 4	Show » « Hide Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM	Show » « Hide GO:0000166 [nucleotide binding] GO:0000902 [cell morphogenesis] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0006954 [inflammatory response] GO:0007569 [cell aging] GO:0008285 [negative regulation of cell proliferation] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016491 [oxidoreductase activity] GO:0019826 [oxygen sensor activity] GO:0020037 [heme binding] GO:0042554 [superoxide anion generation] GO:0050660 [flavin adenine dinucleotide binding] GO:0050667 [homocysteine metabolic process] GO:0055114 [oxidation-reduction process] GO:0072341 [modified amino acid binding] GO:0072593 [reactive oxygen species metabolic process]	231	27.6	No	1
NOX4-013	ENSP00000436892 ENST00000534731	Q9NPH5 Show all » « Hide Q9NPH5 [Direct mapping] NADPH oxidase 4	Show » « Hide Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM	Show » « Hide GO:0000166 [nucleotide binding] GO:0000902 [cell morphogenesis] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0006954 [inflammatory response] GO:0007569 [cell aging] GO:0008285 [negative regulation of cell proliferation] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016491 [oxidoreductase activity] GO:0019826 [oxygen sensor activity] GO:0020037 [heme binding] GO:0042554 [superoxide anion generation] GO:0050660 [flavin adenine dinucleotide binding] GO:0050667 [homocysteine metabolic process] GO:0055114 [oxidation-reduction process] GO:0072341 [modified amino acid binding] GO:0072593 [reactive oxygen species metabolic process]	538	62.7	No	6
NOX4-201	ENSP00000412446 ENST00000424319	Q9NPH5 Show all » « Hide Q9NPH5 [Direct mapping] NADPH oxidase 4	Show » « Hide Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM	Show » « Hide GO:0000166 [nucleotide binding] GO:0000902 [cell morphogenesis] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0006954 [inflammatory response] GO:0007569 [cell aging] GO:0008285 [negative regulation of cell proliferation] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016491 [oxidoreductase activity] GO:0019826 [oxygen sensor activity] GO:0020037 [heme binding] GO:0042554 [superoxide anion generation] GO:0050660 [flavin adenine dinucleotide binding] GO:0050667 [homocysteine metabolic process] GO:0055114 [oxidation-reduction process] GO:0072341 [modified amino acid binding] GO:0072593 [reactive oxygen species metabolic process]	554	64.1	No	6

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx