Tissue expression of CAD - Summary - The Human Protein Atlas

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CAD

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	CAD
Gene description	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Data reliability	Uncertain based on 1 antibody. CAB007781
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

N/A

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CAD
Synonyms
Description	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (HGNC Symbol)
Entrez gene summary	The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	27217390 - 27243943
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000084774 (version 78.38)
Entrez gene	790
UniProt	P27708 (UniProt - Evidence at protein level)
neXtProt	NX_P27708
Antibodypedia	CAD antibodies

PROTEIN BROWSER

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ENST00000264705		ENST00000403525		ENST00000428460		ENST00000456311		ENST00000458503

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
CAD-001	ENSP00000264705 ENST00000264705	P27708 Show all » « Hide P27708 [Direct mapping] CAD protein Glutamine-dependent carbamoyl-phosphate synthase Aspartate carbamoyltransferase Dihydroorotase Q53SY7 [Target identity:96%; Query identity:100%] Putative uncharacterized protein CAD {ECO:0000313\|EMBL:AAY24293.1} G1UI39 [Target identity:8%; Query identity:100%] CAD protein {ECO:0000313\|EMBL:BAK64162.1} Q53SZ4 [Target identity:3%; Query identity:100%] Putative uncharacterized protein CAD {ECO:0000313\|EMBL:AAX93165.1}	Show » « Hide Enzymes ENZYME proteins Transferases Hydrolases Ligase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001889 [liver development] GO:0003824 [catalytic activity] GO:0004070 [aspartate carbamoyltransferase activity] GO:0004088 [carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity] GO:0004151 [dihydroorotase activity] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process] GO:0006228 [UTP biosynthetic process] GO:0006520 [cellular amino acid metabolic process] GO:0006541 [glutamine metabolic process] GO:0006543 [glutamine catabolic process] GO:0006807 [nitrogen compound metabolic process] GO:0007507 [heart development] GO:0007565 [female pregnancy] GO:0007595 [lactation] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0008716 [D-alanine-D-alanine ligase activity] GO:0014075 [response to amine] GO:0016020 [membrane] GO:0016363 [nuclear matrix] GO:0016597 [amino acid binding] GO:0016743 [carboxyl- or carbamoyltransferase activity] GO:0016787 [hydrolase activity] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0017144 [drug metabolic process] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0031000 [response to caffeine] GO:0031100 [organ regeneration] GO:0033574 [response to testosterone] GO:0035690 [cellular response to drug] GO:0042802 [identical protein binding] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043195 [terminal bouton] GO:0043234 [protein complex] GO:0044205 ['de novo' UMP biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046134 [pyrimidine nucleoside biosynthetic process] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0051414 [response to cortisol] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular vesicular exosome] GO:0070335 [aspartate binding] GO:0070409 [carbamoyl phosphate biosynthetic process] GO:0071364 [cellular response to epidermal growth factor stimulus]	2225	243	No
CAD-002	ENSP00000384510 ENST00000403525	F8VPD4 Show all » « Hide F8VPD4 [Target identity:100%; Query identity:100%] CAD protein {ECO:0000313\|Ensembl:ENSP00000384510} G1UI39 [Target identity:9%; Query identity:100%] CAD protein {ECO:0000313\|EMBL:BAK64162.1} Q53SZ4 [Target identity:3%; Query identity:100%] Putative uncharacterized protein CAD {ECO:0000313\|EMBL:AAX93165.1}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003824 [catalytic activity] GO:0004070 [aspartate carbamoyltransferase activity] GO:0005524 [ATP binding] GO:0006207 ['de novo' pyrimidine nucleobase biosynthetic process] GO:0006520 [cellular amino acid metabolic process] GO:0006543 [glutamine catabolic process] GO:0006807 [nitrogen compound metabolic process] GO:0008152 [metabolic process] GO:0008716 [D-alanine-D-alanine ligase activity] GO:0016597 [amino acid binding] GO:0016743 [carboxyl- or carbamoyltransferase activity] GO:0016787 [hydrolase activity] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0016812 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides] GO:0046872 [metal ion binding] GO:0070409 [carbamoyl phosphate biosynthetic process]	2162	236	No
CAD-004	ENSP00000388740 ENST00000456311		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0006520 [cellular amino acid metabolic process] GO:0016597 [amino acid binding] GO:0016743 [carboxyl- or carbamoyltransferase activity] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]	280	31.1	No
CAD-008	ENSP00000414742 ENST00000458503		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016787 [hydrolase activity]	269	28.9	No
CAD-011	ENSP00000405416 ENST00000428460		Show » « Hide SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0006520 [cellular amino acid metabolic process] GO:0016597 [amino acid binding] GO:0016743 [carboxyl- or carbamoyltransferase activity]	293	32.2	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx