Tissue expression of FGFR1 - Summary - The Human Protein Atlas

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FGFR1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	FGFR1
Gene description	Fibroblast growth factor receptor 1
Protein class	Cancer-related genes CD markers Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins RAS pathway related proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	20
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic, nuclear and membranous expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 2 antibodies. HPA056402 , CAB033614
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	FGFR1 (HGNC Symbol)
Synonyms	BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM
Description	Fibroblast growth factor receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	38411138 - 38468834
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000077782 (version 78.38)
Entrez gene	2260
UniProt	P11362 (UniProt - Evidence at protein level)
neXtProt	NX_P11362
Antibodypedia	FGFR1 antibodies

PROTEIN BROWSER

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ENST00000326324		ENST00000335922		ENST00000341462		ENST00000356207		ENST00000397091		ENST00000397103		ENST00000397108		ENST00000397113		ENST00000413133		ENST00000425967		ENST00000434187		ENST00000440174		ENST00000447712		ENST00000525001		ENST00000526742		ENST00000529552		ENST00000530568		ENST00000532791		ENST00000533668		ENST00000619564

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
FGFR1-001	ENSP00000380280 ENST00000397091	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:47%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b {ECO:0000313\|EMBL:EAW63313.1} E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} C9J205 [Target identity:12%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000400708}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000165 [MAPK cascade] GO:0001501 [skeletal system development] GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031410 [cytoplasmic vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048705 [skeletal system morphogenesis]	820	91.6	Yes	1
FGFR1-002	ENSP00000432972 ENST00000532791	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:47%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b {ECO:0000313\|EMBL:EAW63313.1} E9PNM3 [Target identity:36%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434712} E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} C9J205 [Target identity:12%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000400708}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000165 [MAPK cascade] GO:0001501 [skeletal system development] GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031410 [cytoplasmic vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048705 [skeletal system morphogenesis]	820	91.7	Yes	1
FGFR1-003	ENSP00000337247 ENST00000335922	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:47%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b {ECO:0000313\|EMBL:EAW63313.1} E9PN14 [Target identity:17%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000165 [MAPK cascade] GO:0001501 [skeletal system development] GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031410 [cytoplasmic vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048705 [skeletal system morphogenesis]	812	90.6	No	1
FGFR1-004	ENSP00000348537 ENST00000356207	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:52%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b {ECO:0000313\|EMBL:EAW63313.1} E9PKV7 [Target identity:19%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000435283} E9PN14 [Target identity:18%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} C9J1L5 [Target identity:7%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000392645}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000165 [MAPK cascade] GO:0001501 [skeletal system development] GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031410 [cytoplasmic vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048705 [skeletal system morphogenesis]	733	82.2	Yes	1
FGFR1-008	ENSP00000327229 ENST00000326324	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:52%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b {ECO:0000313\|EMBL:EAW63313.1} E9PKF2 [Target identity:19%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000433569} E9PN14 [Target identity:19%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} E9PQ40 [Target identity:11%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434473} C9J1L5 [Target identity:7%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000392645}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000165 [MAPK cascade] GO:0001501 [skeletal system development] GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031410 [cytoplasmic vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048705 [skeletal system morphogenesis]	731	81.9	Yes	1
FGFR1-011	ENSP00000380292 ENST00000397103	E7EU09 Show all » « Hide E7EU09 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor {ECO:0000256\|PIRNR:PIRNR000628} D3DSX2 [Target identity:52%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b {ECO:0000313\|EMBL:EAW63313.1} E9PKF2 [Target identity:19%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000433569} E9PN14 [Target identity:18%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} E9PQ40 [Target identity:11%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434473} C9J1L5 [Target identity:7%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000392645}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation]	733	82	Yes	1
FGFR1-012	ENSP00000380302 ENST00000397113	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:47%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b {ECO:0000313\|EMBL:EAW63313.1} E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} C9J205 [Target identity:12%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000400708}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000165 [MAPK cascade] GO:0001501 [skeletal system development] GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031410 [cytoplasmic vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048705 [skeletal system morphogenesis]	820	91.6	Yes	1
FGFR1-015	ENSP00000400708 ENST00000413133	C9J205 Show all » « Hide C9J205 [Target identity:99%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000400708}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	107	11.9	Yes	0
FGFR1-016	ENSP00000392645 ENST00000434187	C9J1L5 Show all » « Hide C9J1L5 [Target identity:98%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000392645}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		55	6.2	Yes	0
FGFR1-019	ENSP00000398318 ENST00000440174		Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		1	0.1	No	0
FGFR1-020	ENSP00000380297 ENST00000397108	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:47%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b {ECO:0000313\|EMBL:EAW63313.1} E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} C9J205 [Target identity:12%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000400708}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000165 [MAPK cascade] GO:0001501 [skeletal system development] GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031410 [cytoplasmic vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048705 [skeletal system morphogenesis]	820	91.6	Yes	1
FGFR1-027	ENSP00000434473 ENST00000530568	E9PQ40 Show all » « Hide E9PQ40 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434473} C9J1L5 [Target identity:63%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000392645}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0008543 [fibroblast growth factor receptor signaling pathway]	85	9.5	Yes	0
FGFR1-028	ENSP00000434869 ENST00000533668	E9PN14 Show all » « Hide E9PN14 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	139	15.7	No	0
FGFR1-036	ENSP00000434712 ENST00000525001	E9PNM3 Show all » « Hide E9PNM3 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434712} C9J205 [Target identity:35%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000400708}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0008543 [fibroblast growth factor receptor signaling pathway]	298	33.3	Yes	0
FGFR1-037	ENSP00000435283 ENST00000529552	E9PKV7 Show all » « Hide E9PKV7 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000435283} C9J1L5 [Target identity:38%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000392645}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0008543 [fibroblast growth factor receptor signaling pathway]	142	16	Yes	0
FGFR1-038	ENSP00000433569 ENST00000526742	E9PKF2 Show all » « Hide E9PKF2 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000433569} E9PQ40 [Target identity:58%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434473} C9J1L5 [Target identity:37%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000392645}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0008543 [fibroblast growth factor receptor signaling pathway]	145	16.4	Yes	0
FGFR1-201	ENSP00000340636 ENST00000341462	C1KBH7 Show all » « Hide C1KBH7 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1 isoform 3 {ECO:0000313\|EMBL:ACO38645.1} E9PN14 [Target identity:37%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} C9J205 [Target identity:28%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000400708}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	367	40.7	Yes	0
FGFR1-202	ENSP00000393312 ENST00000425967	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:45%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b {ECO:0000313\|EMBL:EAW63313.1} E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} C9J205 [Target identity:12%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000400708}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007411 [axon guidance] GO:0007420 [brain development] GO:0007435 [salivary gland morphogenesis] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010468 [regulation of gene expression] GO:0010518 [positive regulation of phospholipase activity] GO:0010629 [negative regulation of gene expression] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0021769 [orbitofrontal cortex development] GO:0021847 [ventricular zone neuroblast division] GO:0030324 [lung development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031410 [cytoplasmic vesicle] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048514 [blood vessel morphogenesis] GO:0048699 [generation of neurons] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0090080 [positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway] GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand]	853	95.3	No	1
FGFR1-203	ENSP00000400162 ENST00000447712	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:46%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b {ECO:0000313\|EMBL:EAW63313.1} E9PNM3 [Target identity:36%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434712} E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} C9J205 [Target identity:12%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000400708}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000165 [MAPK cascade] GO:0001501 [skeletal system development] GO:0001764 [neuron migration] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007411 [axon guidance] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031410 [cytoplasmic vesicle] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0046777 [protein autophosphorylation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048705 [skeletal system morphogenesis]	822	91.9	Yes	1
FGFR1-204	ENSP00000484553 ENST00000619564	B5A958 Show all » « Hide B5A958 [Target identity:100%; Query identity:100%] Soluble FGFR1 variant 1 {ECO:0000313\|EMBL:ACF47632.1} E9PKF2 [Target identity:63%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000433569} E9PN14 [Target identity:60%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434869} E9PQ40 [Target identity:37%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000434473} C9J1L5 [Target identity:23%; Query identity:100%] Fibroblast growth factor receptor 1 {ECO:0000313\|Ensembl:ENSP00000392645}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0008543 [fibroblast growth factor receptor signaling pathway]	228	25.8	Yes	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx