Tissue expression of PRKCZ - Summary - The Human Protein Atlas

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PRKCZ

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	PRKCZ
Gene description	Protein kinase C, zeta
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	17
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic positivity in most tissues.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Data reliability	Supportive based on 2 antibodies. HPA021851 , CAB004533
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Mixed

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enhanced (cerebellum)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	PRKCZ (HGNC Symbol)
Synonyms	PKC2
Description	Protein kinase C, zeta (HGNC Symbol)
Entrez gene summary	Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	2050470 - 2185395
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000067606 (version 78.38)
Entrez gene	5590
UniProt	Q05513 (UniProt - Evidence at protein level)
neXtProt	NX_Q05513
Antibodypedia	PRKCZ antibodies

PROTEIN BROWSER

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ENST00000378567		ENST00000400920		ENST00000400921		ENST00000461106		ENST00000461465		ENST00000466352		ENST00000468310		ENST00000470511		ENST00000470596		ENST00000470986		ENST00000471018		ENST00000482686		ENST00000486681		ENST00000495347		ENST00000496325		ENST00000497183		ENST00000503297

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
PRKCZ-001	ENSP00000367830 ENST00000378567	Q05513 Show all » « Hide Q05513 [Direct mapping] Protein kinase C zeta type D6RAU1 [Target identity:22%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424763} D6RGG1 [Target identity:18%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421219} F2Z2H9 [Target identity:17%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422764} D6RBD4 [Target identity:16%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424228} D6RG01 [Target identity:13%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421350} D6RDM0 [Target identity:12%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000425317} D6RAN5 [Target identity:11%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421869} D6REZ8 [Target identity:10%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421587} J3KRP7 [Target identity:10%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000462105} D6RC84 [Target identity:7%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:4%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:3%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005923 [tight junction] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007596 [blood coagulation] GO:0007616 [long-term memory] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0016363 [nuclear matrix] GO:0016477 [cell migration] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018105 [peptidyl-serine phosphorylation] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0030010 [establishment of cell polarity] GO:0030054 [cell junction] GO:0030168 [platelet activation] GO:0031252 [cell leading edge] GO:0031333 [negative regulation of protein complex assembly] GO:0031532 [actin cytoskeleton reorganization] GO:0031584 [activation of phospholipase D activity] GO:0031941 [filamentous actin] GO:0032148 [activation of protein kinase B activity] GO:0032753 [positive regulation of interleukin-4 production] GO:0032869 [cellular response to insulin stimulus] GO:0034613 [cellular protein localization] GO:0035556 [intracellular signal transduction] GO:0035748 [myelin sheath abaxonal region] GO:0043066 [negative regulation of apoptotic process] GO:0043203 [axon hillock] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0043274 [phospholipase binding] GO:0043560 [insulin receptor substrate binding] GO:0045121 [membrane raft] GO:0045179 [apical cortex] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0046326 [positive regulation of glucose import] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0047496 [vesicle transport along microtubule] GO:0048471 [perinuclear region of cytoplasm] GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] GO:0050806 [positive regulation of synaptic transmission] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051222 [positive regulation of protein transport] GO:0051291 [protein heterooligomerization] GO:0051346 [negative regulation of hydrolase activity] GO:0051899 [membrane depolarization] GO:0060081 [membrane hyperpolarization] GO:0060291 [long-term synaptic potentiation] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070528 [protein kinase C signaling] GO:0071889 [14-3-3 protein binding] GO:0072659 [protein localization to plasma membrane] GO:1990138 [neuron projection extension] GO:2000463 [positive regulation of excitatory postsynaptic membrane potential] GO:2000553 [positive regulation of T-helper 2 cell cytokine production] GO:2000664 [positive regulation of interleukin-5 secretion] GO:2000667 [positive regulation of interleukin-13 secretion] GO:2001181 [positive regulation of interleukin-10 secretion]	592	67.7	No
PRKCZ-003	ENSP00000425317 ENST00000482686	D6RDM0 Show all » « Hide D6RDM0 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000425317} D6RAN5 [Target identity:95%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421869} J3KRP7 [Target identity:83%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000462105} D6RC84 [Target identity:63%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:34%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:28%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		73	8	No
PRKCZ-004	ENSP00000422349 ENST00000471018	D6RC84 Show all » « Hide D6RC84 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:54%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:45%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		46	5.1	No
PRKCZ-006	ENSP00000427134 ENST00000466352	D6RCN4 Show all » « Hide D6RCN4 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:84%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		25	2.8	No
PRKCZ-007	ENSP00000424945 ENST00000468310	F2Z3C5 Show all » « Hide F2Z3C5 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424945} D6RCN4 [Target identity:13%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:11%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding]	181	20.7	No
PRKCZ-009	ENSP00000383712 ENST00000400921	Q05513 Show all » « Hide Q05513 [Direct mapping] Protein kinase C zeta type D6RAU1 [Target identity:33%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424763} D6RGG1 [Target identity:26%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421219} F2Z2H9 [Target identity:25%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422764} D6RBD4 [Target identity:23%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424228} D6RG01 [Target identity:20%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421350} D6RAN5 [Target identity:17%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421869} D6RDM0 [Target identity:17%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000425317} J3KRP7 [Target identity:14%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000462105} D6RC84 [Target identity:11%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:6%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:5%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018105 [peptidyl-serine phosphorylation] GO:0030010 [establishment of cell polarity] GO:0030054 [cell junction] GO:0030168 [platelet activation] GO:0031333 [negative regulation of protein complex assembly] GO:0032753 [positive regulation of interleukin-4 production] GO:0043560 [insulin receptor substrate binding] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060291 [long-term synaptic potentiation] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:2000463 [positive regulation of excitatory postsynaptic membrane potential] GO:2000553 [positive regulation of T-helper 2 cell cytokine production] GO:2000664 [positive regulation of interleukin-5 secretion] GO:2000667 [positive regulation of interleukin-13 secretion] GO:2001181 [positive regulation of interleukin-10 secretion]	409	46.6	No
PRKCZ-010	ENSP00000421219 ENST00000470986	D6RGG1 Show all » « Hide D6RGG1 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421219} F2Z2H9 [Target identity:96%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422764} D6RBD4 [Target identity:89%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424228} D6RG01 [Target identity:75%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421350} D6RDM0 [Target identity:66%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000425317} D6RAN5 [Target identity:64%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421869} J3KRP7 [Target identity:55%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000462105} D6RC84 [Target identity:42%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:22%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:19%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	109	12.2	No
PRKCZ-011	ENSP00000422764 ENST00000497183	F2Z2H9 Show all » « Hide F2Z2H9 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422764}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	105	11.7	No
PRKCZ-015	ENSP00000426412 ENST00000461106	Q05513 Show all » « Hide Q05513 [Direct mapping] Protein kinase C zeta type D6RAU1 [Target identity:27%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424763} D6RGG1 [Target identity:22%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421219} F2Z2H9 [Target identity:21%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422764} D6RBD4 [Target identity:20%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424228} D6RG01 [Target identity:16%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421350} D6RAN5 [Target identity:14%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421869} D6RDM0 [Target identity:14%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000425317} J3KRP7 [Target identity:12%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000462105} D6RC84 [Target identity:9%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:5%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:4%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018105 [peptidyl-serine phosphorylation] GO:0030010 [establishment of cell polarity] GO:0030054 [cell junction] GO:0030168 [platelet activation] GO:0031333 [negative regulation of protein complex assembly] GO:0032753 [positive regulation of interleukin-4 production] GO:0035556 [intracellular signal transduction] GO:0043560 [insulin receptor substrate binding] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060291 [long-term synaptic potentiation] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:2000463 [positive regulation of excitatory postsynaptic membrane potential] GO:2000553 [positive regulation of T-helper 2 cell cytokine production] GO:2000664 [positive regulation of interleukin-5 secretion] GO:2000667 [positive regulation of interleukin-13 secretion] GO:2001181 [positive regulation of interleukin-10 secretion]	488	56.1	No
PRKCZ-016	ENSP00000462105 ENST00000461465	J3KRP7 Show all » « Hide J3KRP7 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000462105} D6RC84 [Target identity:75%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:40%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:34%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		61	6.7	No
PRKCZ-017	ENSP00000424228 ENST00000470596	D6RBD4 Show all » « Hide D6RBD4 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424228} D6RG01 [Target identity:83%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421350} D6RDM0 [Target identity:74%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000425317} D6RAN5 [Target identity:71%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421869} J3KRP7 [Target identity:62%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000462105} D6RC84 [Target identity:46%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:25%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:21%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	98	10.9	No
PRKCZ-018	ENSP00000421869 ENST00000496325	D6RAN5 Show all » « Hide D6RAN5 [Target identity:98%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421869} J3KRP7 [Target identity:85%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000462105} D6RC84 [Target identity:64%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:35%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:29%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		71	7.8	No
PRKCZ-020	ENSP00000427085 ENST00000495347	D6RD31 Show all » « Hide D6RD31 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		21	2.3	No
PRKCZ-021	ENSP00000421350 ENST00000470511	D6RG01 Show all » « Hide D6RG01 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421350} D6RDM0 [Target identity:89%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000425317} D6RAN5 [Target identity:85%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421869} J3KRP7 [Target identity:74%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000462105} D6RC84 [Target identity:56%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:30%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:25%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		82	9	No
PRKCZ-022	ENSP00000424763 ENST00000486681	D6RAU1 Show all » « Hide D6RAU1 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424763} F2Z2H9 [Target identity:77%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422764}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	136	15.3	No
PRKCZ-026	ENSP00000421587 ENST00000503297	D6REZ8 Show all » « Hide D6REZ8 [Target identity:100%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421587}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	65	7.4	No
PRKCZ-201	ENSP00000383711 ENST00000400920	Q05513 Show all » « Hide Q05513 [Direct mapping] Protein kinase C zeta type D6RAU1 [Target identity:33%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424763} D6RGG1 [Target identity:26%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421219} F2Z2H9 [Target identity:25%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422764} D6RBD4 [Target identity:23%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000424228} D6RG01 [Target identity:20%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421350} D6RAN5 [Target identity:17%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000421869} D6RDM0 [Target identity:17%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000425317} J3KRP7 [Target identity:14%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000462105} D6RC84 [Target identity:11%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000422349} D6RCN4 [Target identity:6%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427134} D6RD31 [Target identity:5%; Query identity:100%] Protein kinase C zeta type {ECO:0000313\|Ensembl:ENSP00000427085}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018105 [peptidyl-serine phosphorylation] GO:0030010 [establishment of cell polarity] GO:0030054 [cell junction] GO:0030168 [platelet activation] GO:0031333 [negative regulation of protein complex assembly] GO:0032753 [positive regulation of interleukin-4 production] GO:0043560 [insulin receptor substrate binding] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060291 [long-term synaptic potentiation] GO:0070062 [extracellular vesicular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:2000463 [positive regulation of excitatory postsynaptic membrane potential] GO:2000553 [positive regulation of T-helper 2 cell cytokine production] GO:2000664 [positive regulation of interleukin-5 secretion] GO:2000667 [positive regulation of interleukin-13 secretion] GO:2001181 [positive regulation of interleukin-10 secretion]	409	46.6	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx