DDX3Y

GENE INFORMATION

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Gene name

DDX3Y (HGNC Symbol)

Synonyms

DBY

Description

DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Chromosome

Y

Cytoband

q11.221

Chromosome location (bp)

12904108 - 12920478

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000067048 (version 78.38)

Entrez gene

8653

UniProt

O15523 (UniProt - Evidence at protein level)

neXtProt

NX_O15523

Antibodypedia

DDX3Y antibodies
 

PROTEIN VIEW

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DDX3Y-001
 
DDX3Y-003
 
DDX3Y-004
 
DDX3Y-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DDX3Y-001 ENSP00000353284
ENST00000360160
O15523
Show all »
Show » Show » 660 73.2 No 0
DDX3Y-003 ENSP00000336725
ENST00000336079
O15523
Show all »
Show » Show » 660 73.2 No 0
DDX3Y-004 ENSP00000398953
ENST00000454054
C9J8G5
Show all »
Show » 224 25 No 0
DDX3Y-005 ENSP00000400377
ENST00000440554
C9J081
Show all »
Show » Show » 250 27.7 No 0