ABCA7 - Gene info - The Human Protein Atlas

Gene name

ABCA7 (HGNC Symbol)

Synonyms

ABCX

Description

ATP-binding cassette, sub-family A (ABC1), member 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p13.3

Chromosome location (bp)

1040101 - 1065572

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000064687 (version 78.38)

Entrez gene

10347

UniProt

Q8IZY2 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCA7-001

ENSP00000414062
ENST00000433129

Q8IZY2
Show all » « Hide

Q8IZY2 [Direct mapping]
ATP-binding cassette sub-family A member 7
E9PL63 [Target identity:7%; Query identity:100%]
ATP-binding cassette sub-family A member 7 {ECO:0000313|Ensembl:ENSP00000431473}

Show » « Hide

Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)

Show » « Hide

GO:0001891 [phagocytic cup]
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006200 [ATP catabolic process]
GO:0006909 [phagocytosis]
GO:0007613 [memory]
GO:0009986 [cell surface]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017121 [phospholipid scrambling]
GO:0018149 [peptide cross-linking]
GO:0032587 [ruffle membrane]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034188 [apolipoprotein A-I receptor activity]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034504 [protein localization to nucleus]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0050766 [positive regulation of phagocytosis]
GO:0055085 [transmembrane transport]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1900223 [positive regulation of beta-amyloid clearance]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1902430 [negative regulation of beta-amyloid formation]
GO:1902995 [positive regulation of phospholipid efflux]

2146

234.3

ABCA7-002

ENSP00000465322
ENST00000435683

Q8IZY2
Show all » « Hide

Q8IZY2 [Direct mapping]
ATP-binding cassette sub-family A member 7

Show » « Hide

2008

218.5

ABCA7-006

ENSP00000431473
ENST00000524850

E9PL63
Show all » « Hide

E9PL63 [Target identity:100%; Query identity:100%]
ATP-binding cassette sub-family A member 7 {ECO:0000313|Ensembl:ENSP00000431473}

Show » « Hide

   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

164

18.4

ABCA7-007

ENSP00000433545
ENST00000531467

E9PKG5
Show all » « Hide

E9PKG5 [Target identity:100%; Query identity:100%]
ATP-binding cassette sub-family A member 7 {ECO:0000313|Ensembl:ENSP00000433545}

Show » « Hide

136

15.4

ABCA7-012

ENSP00000482948
ENST00000612569

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Show » « Hide

GO:0005524 [ATP binding]
GO:0016887 [ATPase activity]

280

ABCA7-013

ENSP00000432031
ENST00000525073

B3KUJ3
Show all » « Hide

B3KUJ3 [Target identity:94%; Query identity:100%]
cDNA FLJ40025 fis, clone STOMA2008050, highly similar to Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 7 (ABCA7), transcript variant 2, mRNA {ECO:0000313|EMBL:BAG53455.1}

Show » « Hide

Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)

Show » « Hide

GO:0005524 [ATP binding]
GO:0016887 [ATPase activity]

591

64.5

ABCA7-018

ENSP00000478857
ENST00000611490

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)

4.6

ABCA7-201

ENSP00000263094
ENST00000263094

Q8IZY2
Show all » « Hide

Q8IZY2 [Direct mapping]
ATP-binding cassette sub-family A member 7
E9PL63 [Target identity:7%; Query identity:100%]
ATP-binding cassette sub-family A member 7 {ECO:0000313|Ensembl:ENSP00000431473}

Show » « Hide

GO:0001891 [phagocytic cup]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006200 [ATP catabolic process]
GO:0006909 [phagocytosis]
GO:0007613 [memory]
GO:0009986 [cell surface]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016887 [ATPase activity]
GO:0017121 [phospholipid scrambling]
GO:0018149 [peptide cross-linking]
GO:0032587 [ruffle membrane]
GO:0032780 [negative regulation of ATPase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034188 [apolipoprotein A-I receptor activity]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034504 [protein localization to nucleus]
GO:0038027 [apolipoprotein A-I-mediated signaling pathway]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0043190 [ATP-binding cassette (ABC) transporter complex]
GO:0050766 [positive regulation of phagocytosis]
GO:0055085 [transmembrane transport]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1900223 [positive regulation of beta-amyloid clearance]
GO:1901076 [positive regulation of engulfment of apoptotic cell]
GO:1902430 [negative regulation of beta-amyloid formation]
GO:1902995 [positive regulation of phospholipid efflux]

2146

234.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.