PKP2

GENE INFORMATION

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Gene name

PKP2

Synonyms

Description

Plakophilin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p11.21

Chromosome location (bp)

32790745 - 32896840

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000057294 (version 78.38)

Entrez gene

5318

UniProt

Q99959 (UniProt - Evidence at protein level)

neXtProt

NX_Q99959

Antibodypedia

PKP2 antibodies
 

PROTEIN VIEW

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PKP2-001
 
PKP2-002
 
PKP2-003
 
PKP2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PKP2-001 ENSP00000342800
ENST00000340811
Q99959
Show all »
Show » Show » 837 92.8 No 0
PKP2-002 ENSP00000070846
ENST00000070846
Q99959
Show all »
Show » Show » 881 97.4 No 0
PKP2-003 ENSP00000481383
ENST00000546741
Show » 36 3.7 No 0
PKP2-201 ENSP00000478295
ENST00000613243
B8QGS9
Show all »
Show » Show » 824 91.2 No 0