MAPK9

GENERAL INFORMATION

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Gene name

MAPK9

Gene description

Mitogen-activated protein kinase 9

Protein class

Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic and nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
CAB008910
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MAPK9 (HGNC Symbol)

Synonyms

JNK2, p54a, PRKM9, SAPK

Description

Mitogen-activated protein kinase 9 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

Chromosome

5

Cytoband

q35.3

Chromosome location (bp)

180233143 - 180292099

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000050748 (version 78.38)

Entrez gene

5601

UniProt

P45984 (UniProt - Evidence at protein level)

neXtProt

NX_P45984

Antibodypedia

MAPK9 antibodies


PROTEIN BROWSER

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ENST00000343111
 
ENST00000347470
 
ENST00000393360
 
ENST00000397072
 
ENST00000425491
 
ENST00000452135
 
ENST00000455781
 
ENST00000523583
 
ENST00000539014
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPK9-001 ENSP00000394560
ENST00000452135
P45984
Show all »
Show » Show » 424 48.1 No 0
MAPK9-002 ENSP00000345524
ENST00000343111
P45984
Show all »
Show » Show » 382 44.2 No 0
MAPK9-003 ENSP00000377028
ENST00000393360
P45984
Show all »
Show » Show » 382 44.1 No 0
MAPK9-004 ENSP00000389338
ENST00000455781
P45984
Show all »
Show » Show » 424 48.3 No 0
MAPK9-005 ENSP00000397422
ENST00000425491
P45984
Show all »
Show » Show » 242 27.3 No 0
MAPK9-006 ENSP00000321410
ENST00000347470
J3KNK1
Show all »
Show » Show » 339 38.2 No 0
MAPK9-012 ENSP00000430608
ENST00000523583
E5RJ57
Show all »
Show » Show » 104 11.7 No 0
MAPK9-201 ENSP00000380262
ENST00000397072
D7R528
Show all »
Show » Show » 124 13.7 No 0
MAPK9-202 ENSP00000443149
ENST00000539014
D7R525
Show all »
Show » Show » 214 24.6 No 0