CASR

GENERAL INFORMATION

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Gene name

CASR

Gene description

Calcium-sensing receptor

Protein class

Disease related genes
FDA approved drug targets
G-protein coupled receptors
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (gallbladder, kidney)
GTEx:Group enriched (kidney, pancreas)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous expression in a subset of renal tubules, islets of Langerhans and parathyroid gland.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA039686 , HPA050335
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (gallbladder, kidney)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (kidney, pancreas)

Organ

Expression



GENE INFORMATION

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Gene name

CASR (HGNC Symbol)

Synonyms

FHH, GPRC2A, HHC, HHC1, NSHPT

Description

Calcium-sensing receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

Chromosome location (bp)

122183683 - 122286503

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000036828 (version 78.38)

Entrez gene

846

UniProt

P41180 (UniProt - Evidence at protein level)

neXtProt

NX_P41180

Antibodypedia

CASR antibodies


PROTEIN BROWSER

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ENST00000490131
 
ENST00000498619
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASR-001 ENSP00000418685
ENST00000490131
P41180
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Show » Show » 1078 120.7 Yes 7
CASR-002 ENSP00000420194
ENST00000498619
E7ENE0
Show all »
Show » Show » 1088 121.8 Yes 7