BIRC3 - Gene info - The Human Protein Atlas

Gene name

BIRC3 (HGNC Symbol)

Synonyms

API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49

Description

Baculoviral IAP repeat containing 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]

Chromosome

Cytoband

q22.2

Chromosome location (bp)

102317450 - 102339403

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000023445 (version 78.38)

Entrez gene

330

UniProt

Q13489 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BIRC3-001

ENSP00000432907
ENST00000532808

Q13489
Show all » « Hide

Q13489 [Direct mapping]
Baculoviral IAP repeat-containing protein 3

Show » « Hide

Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0060544 [regulation of necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:2000116 [regulation of cysteine-type endopeptidase activity]

604

68.4

BIRC3-002

ENSP00000263464
ENST00000263464

Q13489
Show all » « Hide

Q13489 [Direct mapping]
Baculoviral IAP repeat-containing protein 3

Show » « Hide

GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042326 [negative regulation of phosphorylation]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045121 [membrane raft]
GO:0050727 [regulation of inflammatory response]
GO:0051291 [protein heterooligomerization]
GO:0060544 [regulation of necroptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:2000116 [regulation of cysteine-type endopeptidase activity]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]

604

68.4

BIRC3-006

ENSP00000431718
ENST00000527309

H0YCJ5
Show all » « Hide

H0YCJ5 [Target identity:100%; Query identity:100%]
Baculoviral IAP repeat-containing protein 3 {ECO:0000313|Ensembl:ENSP00000431718}

Show » « Hide

   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

183

20.7

BIRC3-201

ENSP00000481903
ENST00000615299

Q13489
Show all » « Hide

Q13489 [Direct mapping]
Baculoviral IAP repeat-containing protein 3

Show » « Hide

604

68.4

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.