IGF1

GENERAL INFORMATION

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Gene name

IGF1

Gene description

Insulin-like growth factor 1 (somatomedin C)

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Secreted

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Extracellular deposits and cytoplasmic expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Data reliability

Uncertain based on 1 antibody.
HPA048946
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

IGF1 (HGNC Symbol)

Synonyms

IGF-I, IGF1A, IGFI

Description

Insulin-like growth factor 1 (somatomedin C) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Chromosome

12

Cytoband

q23.2

Chromosome location (bp)

102395867 - 102480645

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000017427 (version 78.38)

Entrez gene

3479

UniProt

P05019 (UniProt - Evidence at protein level)

neXtProt

NX_P05019

Antibodypedia

IGF1 antibodies


PROTEIN BROWSER

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ENST00000307046
 
ENST00000337514
 
ENST00000392904
 
ENST00000392905
 
ENST00000424202
 
ENST00000456098
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGF1-001 ENSP00000337612
ENST00000337514
P05019
Show all »
Show » Show » 153 17 Yes 0
IGF1-002 ENSP00000302665
ENST00000307046
P05019
Show all »
Show » Show » 195 21.8 Yes 0
IGF1-003 ENSP00000376638
ENST00000392905
Q13429
Show all »
Show » Show » 139 15.6 Yes 0
IGF1-004 ENSP00000416811
ENST00000424202
P05019
Show all »
Show » Show » 137 15.2 Yes 0
IGF1-005 ENSP00000376637
ENST00000392904
P05019
Show all »
Show » Show » 158 17.8 Yes 0
IGF1-201 ENSP00000394999
ENST00000456098
P05019
Show all »
Show » Show » 158 17.8 Yes 0