ISL1

GENERAL INFORMATION

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Gene name

ISL1

Gene description

ISL LIM homeobox 1

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (prostate, stomach)
GTEx:Tissue enhanced (prostate, vagina)

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in a few tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA057416
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (prostate, stomach)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (prostate, vagina)

Organ

Expression



GENE INFORMATION

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Gene name

ISL1 (HGNC Symbol)

Synonyms

Isl-1, ISLET1

Description

ISL LIM homeobox 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q11.1

Chromosome location (bp)

51383391 - 51394738

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000016082 (version 78.38)

Entrez gene

3670

UniProt

P61371 (UniProt - Evidence at protein level)

neXtProt

NX_P61371

Antibodypedia

ISL1 antibodies


PROTEIN BROWSER

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ENST00000230658
 
ENST00000511384
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ISL1-001 ENSP00000230658
ENST00000230658
P61371
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Show » Show » 349 39 No 0
ISL1-003 ENSP00000422676
ENST00000511384
D6RBJ1
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Show » Show » 326 36.7 No 0