NR1H4

GENERAL INFORMATION

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Gene name

NR1H4

Gene description

Nuclear receptor subfamily 1, group H, member 4

Protein class

Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (liver, small intestine)
GTEx:Tissue enhanced (adrenal gland, liver, small intestine)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (liver, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adrenal gland, liver, small intestine)

Organ

Expression



GENE INFORMATION

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Gene name

NR1H4 (HGNC Symbol)

Synonyms

FXR, HRR-1, HRR1, RIP14

Description

Nuclear receptor subfamily 1, group H, member 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Chromosome

12

Cytoband

q23.1

Chromosome location (bp)

100473708 - 100564413

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000012504 (version 78.38)

Entrez gene

9971

UniProt

Q96RI1 (UniProt - Evidence at protein level)

neXtProt

NX_Q96RI1

Antibodypedia

NR1H4 antibodies


PROTEIN BROWSER

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ENST00000188403
 
ENST00000392986
 
ENST00000546380
 
ENST00000548884
 
ENST00000549996
 
ENST00000551184
 
ENST00000551379
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NR1H4-001 ENSP00000448506
ENST00000548884
Q96RI1
Show all »
Show » Show » 472 54.4 No 0
NR1H4-002 ENSP00000448978
ENST00000549996
Q96RI1
Show all »
Show » Show » 425 48.8 No 0
NR1H4-003 ENSP00000376712
ENST00000392986
Q96RI1
Show all »
Show » Show » 476 54.9 No 0
NR1H4-005 ENSP00000188403
ENST00000188403
Q96RI1
Show all »
Show » Show » 482 55.5 No 0
NR1H4-006 ENSP00000447149
ENST00000551379
Q96RI1
Show all »
Show » Show » 486 55.9 No 0
NR1H4-007 ENSP00000446861
ENST00000551184
Show » 34 3.8 No 0
NR1H4-008 ENSP00000446760
ENST00000546380
F8W1M1
Show all »
Show » 45 5.2 No 0