Tissue expression of BRCA1 - Summary - The Human Protein Atlas

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BRCA1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	BRCA1
Gene description	Breast cancer 1, early onset
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	23
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic and nuclear expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 3 antibodies. HPA034966 , CAB001946 , CAB018369
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enhanced (testis)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	BRCA1 (HGNC Symbol)
Synonyms	BRCC1, PPP1R53, RNF53
Description	Breast cancer 1, early onset (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	43044295 - 43125483
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000012048 (version 78.38)
Entrez gene	672
UniProt	P38398 (UniProt - Evidence at protein level)
neXtProt	NX_P38398
Antibodypedia	BRCA1 antibodies

PROTEIN BROWSER

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ENST00000352993		ENST00000354071		ENST00000357654		ENST00000461574		ENST00000468300		ENST00000470026		ENST00000471181		ENST00000473961		ENST00000476777		ENST00000477152		ENST00000478531		ENST00000484087		ENST00000487825		ENST00000489037		ENST00000491747		ENST00000493795		ENST00000493919		ENST00000494123		ENST00000497488		ENST00000586385		ENST00000591534		ENST00000591849		ENST00000618469

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
BRCA1-001	ENSP00000350283 ENST00000357654	P38398 Show all » « Hide P38398 [Direct mapping] Breast cancer type 1 susceptibility protein Q3LRH8 [Target identity:97%; Query identity:100%] Breast cancer 1 early onset {ECO:0000313\|EMBL:ABA29229.1}; Early onset breast cancer 1 {ECO:0000313\|EMBL:ABF14462.1} E9PFZ0 [Target identity:97%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418775} E7EWN5 [Target identity:34%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419274} Q3B891 [Target identity:25%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:AAI06746.1}; Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419103} K7EPC7 [Target identity:19%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000467329} Q7KYU6 [Target identity:12%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAB08105.1} C9IZW4 [Target identity:9%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418986} Q4EW25 [Target identity:8%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant {ECO:0000313\|EMBL:AAZ16492.1} A0A068BDT6 [Target identity:6%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83553.1} A0A068BCA1 [Target identity:4%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83551.1} K4JXS7 [Target identity:4%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88804.1} K4K7V3 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88808.1} G4V4Z7 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57768.1} Q3YB53 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79406.1} Q3YB49 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79410.1} G4V503 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57774.1} G4V502 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57773.1} G4V500 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57771.1} G4V4Z8 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57769.1} K4JUB1 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88802.1} C4PFY7 [Target identity:1%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1} A0A068BI53 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1} A0A068BEU9 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83547.1} Q3YB50 [Target identity:1%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79409.1} A0A068BDV0 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83578.1} A0A068BDU7 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} Q92897 [Target identity:1%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1} Q9NQR3 [Target identity:1%; Query identity:100%] BRCAI {ECO:0000313\|EMBL:AAF97939.1}; Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAM18219.1} Q9UE29 [Target identity:1%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:CAA70003.1} G1UI37 [Target identity:1%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1}	Show » « Hide Phobius predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006301 [postreplication repair] GO:0006302 [double-strand break repair] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006633 [fatty acid biosynthetic process] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007059 [chromosome segregation] GO:0008270 [zinc ion binding] GO:0008274 [gamma-tubulin ring complex] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010212 [response to ionizing radiation] GO:0010575 [positive regulation vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0015631 [tubulin binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030529 [ribonucleoprotein complex] GO:0031398 [positive regulation of protein ubiquitination] GO:0031436 [BRCA1-BARD1 complex] GO:0031572 [G2 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0035066 [positive regulation of histone acetylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043234 [protein complex] GO:0043627 [response to estrogen] GO:0044212 [transcription regulatory region DNA binding] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045766 [positive regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046600 [negative regulation of centriole replication] GO:0046872 [metal ion binding] GO:0050681 [androgen receptor binding] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051865 [protein autoubiquitination] GO:0070512 [positive regulation of histone H4-K20 methylation] GO:0070531 [BRCA1-A complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0071356 [cellular response to tumor necrosis factor] GO:0071681 [cellular response to indole-3-methanol] GO:0085020 [protein K6-linked ubiquitination] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2000378 [negative regulation of reactive oxygen species metabolic process] GO:2000617 [positive regulation of histone H3-K9 acetylation] GO:2000620 [positive regulation of histone H4-K16 acetylation]	1863	207.7	No
BRCA1-003	ENSP00000418986 ENST00000497488	C9IZW4 Show all » « Hide C9IZW4 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418986}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004842 [ubiquitin-protein transferase activity] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]	177	20	No
BRCA1-004	ENSP00000419988 ENST00000477152	E9PH68 Show all » « Hide E9PH68 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419988} C9IZW4 [Target identity:28%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418986} Q4EW25 [Target identity:26%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant {ECO:0000313\|EMBL:AAZ16492.1} E7ENB7 [Target identity:15%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000420781} A0A068BI55 [Target identity:7%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83579.1} G4V500 [Target identity:7%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57771.1} G4V502 [Target identity:7%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57773.1} G4V503 [Target identity:7%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57774.1} A0A068BEU9 [Target identity:5%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83547.1} Q92897 [Target identity:4%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1} A0A068BDU7 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} A0A068BI53 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1} G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]	622	70	No
BRCA1-005	ENSP00000418960 ENST00000471181	P38398 Show all » « Hide P38398 [Direct mapping] Breast cancer type 1 susceptibility protein E7EWN5 [Target identity:34%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419274} Q3B891 [Target identity:25%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:AAI06746.1}; Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419103} K7EPC7 [Target identity:18%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000467329} Q7KYU6 [Target identity:12%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAB08105.1} C9IZW4 [Target identity:9%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418986} Q4EW25 [Target identity:8%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant {ECO:0000313\|EMBL:AAZ16492.1} A0A068BDT6 [Target identity:6%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83553.1} A0A068BCA1 [Target identity:4%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83551.1} K4JXS7 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88804.1} K4K7V3 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88808.1} G4V4Z7 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57768.1} G4V4Z8 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57769.1} G4V500 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57771.1} G4V502 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57773.1} G4V503 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57774.1} Q3YB49 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79410.1} Q3YB53 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79406.1} A0A068BI53 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1} Q9UE29 [Target identity:1%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:CAA70003.1} Q9NQR3 [Target identity:1%; Query identity:100%] BRCAI {ECO:0000313\|EMBL:AAF97939.1}; Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAM18219.1} Q92897 [Target identity:1%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1} A0A068BDU7 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} A0A068BDV0 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83578.1} Q3YB50 [Target identity:1%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79409.1} A0A068BEU9 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83547.1} C4PFY7 [Target identity:1%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1} K4JUB1 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88802.1} G1UI37 [Target identity:1%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1}	Show » « Hide Phobius predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0000793 [condensed chromosome] GO:0000794 [condensed nuclear chromosome] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006301 [postreplication repair] GO:0006302 [double-strand break repair] GO:0006349 [regulation of gene expression by genetic imprinting] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006633 [fatty acid biosynthetic process] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007059 [chromosome segregation] GO:0007098 [centrosome cycle] GO:0008270 [zinc ion binding] GO:0008274 [gamma-tubulin ring complex] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0009048 [dosage compensation by inactivation of X chromosome] GO:0010212 [response to ionizing radiation] GO:0010575 [positive regulation vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0015631 [tubulin binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030529 [ribonucleoprotein complex] GO:0031398 [positive regulation of protein ubiquitination] GO:0031436 [BRCA1-BARD1 complex] GO:0031572 [G2 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0035066 [positive regulation of histone acetylation] GO:0035067 [negative regulation of histone acetylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043009 [chordate embryonic development] GO:0043234 [protein complex] GO:0043627 [response to estrogen] GO:0044030 [regulation of DNA methylation] GO:0044212 [transcription regulatory region DNA binding] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045766 [positive regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046600 [negative regulation of centriole replication] GO:0046872 [metal ion binding] GO:0050681 [androgen receptor binding] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051572 [negative regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051574 [positive regulation of histone H3-K9 methylation] GO:0051865 [protein autoubiquitination] GO:0070512 [positive regulation of histone H4-K20 methylation] GO:0070531 [BRCA1-A complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0071356 [cellular response to tumor necrosis factor] GO:0071681 [cellular response to indole-3-methanol] GO:0085020 [protein K6-linked ubiquitination] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2000378 [negative regulation of reactive oxygen species metabolic process] GO:2000617 [positive regulation of histone H3-K9 acetylation] GO:2000620 [positive regulation of histone H4-K16 acetylation]	1884	210.3	No
BRCA1-006	ENSP00000418775 ENST00000493795	E9PFZ0 Show all » « Hide E9PFZ0 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418775} K7EPC7 [Target identity:19%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000467329} Q7KYU6 [Target identity:12%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAB08105.1} Q4EW25 [Target identity:9%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant {ECO:0000313\|EMBL:AAZ16492.1} C9IZW4 [Target identity:9%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418986} A0A068BDT6 [Target identity:6%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83553.1} A0A068BCA1 [Target identity:5%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83551.1} K4JXS7 [Target identity:4%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88804.1} K4K7V3 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88808.1} G4V503 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57774.1} Q3YB53 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79406.1} Q3YB49 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79410.1} G4V502 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57773.1} G4V500 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57771.1} G4V4Z8 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57769.1} G4V4Z7 [Target identity:2%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57768.1} A0A068BEU9 [Target identity:2%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83547.1} K4JUB1 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88802.1} C4PFY7 [Target identity:1%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1} Q3YB50 [Target identity:1%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79409.1} A0A068BI53 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1} A0A068BDU7 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} Q9NQR3 [Target identity:1%; Query identity:100%] BRCAI {ECO:0000313\|EMBL:AAF97939.1}; Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAM18219.1} Q9UE29 [Target identity:1%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:CAA70003.1}	Show » « Hide Phobius predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]	1816	202.3	No
BRCA1-007	ENSP00000417148 ENST00000468300	P38398 Show all » « Hide P38398 [Direct mapping] Breast cancer type 1 susceptibility protein K4JXS7 [Target identity:10%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88804.1} A0A068BCB8 [Target identity:5%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83581.1} A0A068BDV0 [Target identity:5%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83578.1} Q9NQR3 [Target identity:4%; Query identity:100%] BRCAI {ECO:0000313\|EMBL:AAF97939.1}; Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAM18219.1} Q9UE29 [Target identity:4%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:CAA70003.1} A0A068BDU7 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} A0A068BI53 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1} C4PFY7 [Target identity:3%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1} G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1} Q92897 [Target identity:3%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1}	Show » « Hide Phobius predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006301 [postreplication repair] GO:0006302 [double-strand break repair] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006633 [fatty acid biosynthetic process] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007059 [chromosome segregation] GO:0008270 [zinc ion binding] GO:0008274 [gamma-tubulin ring complex] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010212 [response to ionizing radiation] GO:0010575 [positive regulation vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0015631 [tubulin binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030529 [ribonucleoprotein complex] GO:0031398 [positive regulation of protein ubiquitination] GO:0031436 [BRCA1-BARD1 complex] GO:0031572 [G2 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0035066 [positive regulation of histone acetylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043234 [protein complex] GO:0043627 [response to estrogen] GO:0044212 [transcription regulatory region DNA binding] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045766 [positive regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046600 [negative regulation of centriole replication] GO:0046872 [metal ion binding] GO:0050681 [androgen receptor binding] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051865 [protein autoubiquitination] GO:0070512 [positive regulation of histone H4-K20 methylation] GO:0070531 [BRCA1-A complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0071356 [cellular response to tumor necrosis factor] GO:0071681 [cellular response to indole-3-methanol] GO:0085020 [protein K6-linked ubiquitination] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2000378 [negative regulation of reactive oxygen species metabolic process] GO:2000617 [positive regulation of histone H3-K9 acetylation] GO:2000620 [positive regulation of histone H4-K16 acetylation]	699	78.2	No
BRCA1-008	ENSP00000418819 ENST00000493919	B7ZA85 Show all » « Hide B7ZA85 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418819}; cDNA, FLJ79099, highly similar to Homo sapiens breast cancer 1, early onset (BRCA1), transcript variant BRCA1-delta 11b, mRNA {ECO:0000313\|EMBL:BAH14571.1} K4JXS7 [Target identity:13%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88804.1} Q9UE29 [Target identity:5%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:CAA70003.1} A0A068BDU7 [Target identity:4%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} C4PFY7 [Target identity:4%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1} A0A068BI53 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]	572	63.6	No
BRCA1-009	ENSP00000420412 ENST00000478531	E7EUM2 Show all » « Hide E7EUM2 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000420412} E7EQW4 [Target identity:35%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000417554} K4JXS7 [Target identity:12%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88804.1} A0A068BDV0 [Target identity:5%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83578.1} K4K7U9 [Target identity:5%; Query identity:100%] Breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88803.1} Q92897 [Target identity:4%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1} Q9UE29 [Target identity:4%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:CAA70003.1} A0A068BI53 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1} C4PFY7 [Target identity:3%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1} G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0046872 [metal ion binding]	623	69.5	No
BRCA1-011	ENSP00000419274 ENST00000470026	E7EWN5 Show all » « Hide E7EWN5 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419274} Q3B891 [Target identity:72%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:AAI06746.1}; Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419103} C9IZW4 [Target identity:27%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418986} Q4EW25 [Target identity:25%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant {ECO:0000313\|EMBL:AAZ16492.1} G4V503 [Target identity:7%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57774.1} G4V500 [Target identity:6%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57771.1} G4V502 [Target identity:6%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57773.1} A0A068BDV0 [Target identity:5%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83578.1} A0A068BEU9 [Target identity:5%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83547.1} Q92897 [Target identity:4%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1} A0A068BDU7 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} A0A068BI53 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1} G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0046872 [metal ion binding]	649	73.1	No
BRCA1-012	ENSP00000326002 ENST00000354071	Q5YLB2 Show all » « Hide Q5YLB2 [Target identity:100%; Query identity:100%] IRIS {ECO:0000313\|EMBL:AAQ92977.1} E7EWN5 [Target identity:46%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419274} Q3B891 [Target identity:33%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:AAI06746.1}; Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419103} C9IZW4 [Target identity:12%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418986} Q4EW25 [Target identity:11%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant {ECO:0000313\|EMBL:AAZ16492.1} A0A068BDT6 [Target identity:8%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83553.1} A0A068BCA1 [Target identity:6%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83551.1} K4K7V3 [Target identity:4%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88808.1} G4V500 [Target identity:3%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57771.1} G4V503 [Target identity:3%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57774.1} G4V502 [Target identity:3%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57773.1} G4V4Z8 [Target identity:3%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57769.1} G4V4Z7 [Target identity:3%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57768.1} A0A068BEU9 [Target identity:2%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83547.1} Q3YB49 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79410.1} Q3YB50 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79409.1} Q3YB53 [Target identity:2%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAZ79406.1} A0A068BDV0 [Target identity:2%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83578.1} G1UI37 [Target identity:1%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1} K4JUB1 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88802.1} A0A068BI53 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1} A0A068BDU7 [Target identity:1%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} Q92897 [Target identity:1%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0046872 [metal ion binding]	1399	156.3	No
BRCA1-013	ENSP00000419103 ENST00000494123	Q3B891 Show all » « Hide Q3B891 [Target identity:100%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:AAI06746.1}; Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419103} C9IZW4 [Target identity:37%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418986} Q4EW25 [Target identity:35%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant {ECO:0000313\|EMBL:AAZ16492.1} G4V500 [Target identity:9%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57771.1} G4V502 [Target identity:9%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57773.1} G4V503 [Target identity:9%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57774.1} A0A068BDV0 [Target identity:7%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83578.1} A0A068BEU9 [Target identity:7%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83547.1} A0A068BDU7 [Target identity:5%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} Q92897 [Target identity:5%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1} A0A068BI53 [Target identity:4%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1} G1UI37 [Target identity:4%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0046872 [metal ion binding]	473	53.4	No
BRCA1-014	ENSP00000420705 ENST00000491747	P38398 Show all » « Hide P38398 [Direct mapping] Breast cancer type 1 susceptibility protein A0A024R1V0 [Target identity:100%; Query identity:100%] Breast cancer 1, early onset, isoform CRA_d {ECO:0000313\|EMBL:EAW60932.1} B4DES0 [Target identity:93%; Query identity:100%] cDNA FLJ58524, highly similar to Homo sapiens breast cancer 1, early onset (BRCA1), transcript variant BRCA1-delta 11b, mRNA {ECO:0000313\|EMBL:BAG57181.1} K7EPC7 [Target identity:46%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000467329} Q7KYU6 [Target identity:30%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAB08105.1} K4JXS7 [Target identity:9%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88804.1} A0A068BDV0 [Target identity:4%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83578.1} A0A068BDU7 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} C4PFY7 [Target identity:3%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1} G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1} Q92897 [Target identity:3%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1} Q9NQR3 [Target identity:3%; Query identity:100%] BRCAI {ECO:0000313\|EMBL:AAF97939.1}; Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAM18219.1} Q9UE29 [Target identity:3%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:CAA70003.1} A0A068BI53 [Target identity:2%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1}	Show » « Hide Phobius predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006301 [postreplication repair] GO:0006302 [double-strand break repair] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006633 [fatty acid biosynthetic process] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007059 [chromosome segregation] GO:0008270 [zinc ion binding] GO:0008274 [gamma-tubulin ring complex] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010212 [response to ionizing radiation] GO:0010575 [positive regulation vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0015631 [tubulin binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030529 [ribonucleoprotein complex] GO:0031398 [positive regulation of protein ubiquitination] GO:0031436 [BRCA1-BARD1 complex] GO:0031572 [G2 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0035066 [positive regulation of histone acetylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043234 [protein complex] GO:0043627 [response to estrogen] GO:0044212 [transcription regulatory region DNA binding] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045766 [positive regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046600 [negative regulation of centriole replication] GO:0046872 [metal ion binding] GO:0050681 [androgen receptor binding] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051865 [protein autoubiquitination] GO:0070512 [positive regulation of histone H4-K20 methylation] GO:0070531 [BRCA1-A complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0071356 [cellular response to tumor necrosis factor] GO:0071681 [cellular response to indole-3-methanol] GO:0085020 [protein K6-linked ubiquitination] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2000378 [negative regulation of reactive oxygen species metabolic process] GO:2000617 [positive regulation of histone H3-K9 acetylation] GO:2000620 [positive regulation of histone H4-K16 acetylation]	759	85	No
BRCA1-015	ENSP00000419481 ENST00000484087	H0Y8B8 Show all » « Hide H0Y8B8 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000419481} K4JXS7 [Target identity:15%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88804.1} K4K7U9 [Target identity:7%; Query identity:100%] Breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88803.1} Q9UE29 [Target identity:5%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:CAA70003.1} C4PFY7 [Target identity:4%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]	498	55.5	No
BRCA1-016	ENSP00000420781 ENST00000489037	E7ENB7 Show all » « Hide E7ENB7 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000420781} A0A068BI55 [Target identity:47%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83579.1} Q92897 [Target identity:26%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1} G1UI37 [Target identity:23%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1} A0A068BI53 [Target identity:22%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]	98	11.2	No
BRCA1-017	ENSP00000417554 ENST00000476777	E7EQW4 Show all » « Hide E7EQW4 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000417554} A0A068BDV0 [Target identity:16%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83578.1} K4K7U9 [Target identity:16%; Query identity:100%] Breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88803.1} Q92897 [Target identity:11%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1} G1UI37 [Target identity:10%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1} A0A068BI53 [Target identity:9%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0046872 [metal ion binding]	222	25.1	No
BRCA1-018	ENSP00000420201 ENST00000473961	Q4EW25 Show all » « Hide Q4EW25 [Target identity:52%; Query identity:100%] Breast and ovarian cancer suseptibility protein variant {ECO:0000313\|EMBL:AAZ16492.1} G4V500 [Target identity:14%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57771.1} G4V503 [Target identity:14%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57774.1} G4V502 [Target identity:13%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57773.1} A0A068BEU9 [Target identity:11%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83547.1} K4K7U9 [Target identity:11%; Query identity:100%] Breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88803.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		319	35.9	No
BRCA1-019	ENSP00000418212 ENST00000487825	H0Y881 Show all » « Hide H0Y881 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000418212} A0A068BDU7 [Target identity:9%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]	266	29.5	No
BRCA1-022	ENSP00000417241 ENST00000461574	G4V4Z8 Show all » « Hide G4V4Z8 [Target identity:20%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57769.1} G4V4Z7 [Target identity:18%; Query identity:100%] Breast cancer associated protein 1 {ECO:0000313\|EMBL:CCD57768.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		242	26.3	No
BRCA1-023	ENSP00000465818 ENST00000586385	C6YB45 Show all » « Hide C6YB45 [Target identity:100%; Query identity:100%] BRCA1 isoform E1aA-∆2-17 {ECO:0000313\|EMBL:ABC59810.1}; Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000465818} Q9NQR3 [Target identity:16%; Query identity:100%] BRCAI {ECO:0000313\|EMBL:AAF97939.1}; Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAM18219.1} C4PFY7 [Target identity:13%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1}	Show » « Hide Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]	173	19.8	No
BRCA1-024	ENSP00000467329 ENST00000591534	K7EPC7 Show all » « Hide K7EPC7 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000467329} Q7KYU6 [Target identity:65%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAB08105.1} K4JXS7 [Target identity:21%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88804.1} Q9UE29 [Target identity:8%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:CAA70003.1} Q9NQR3 [Target identity:7%; Query identity:100%] BRCAI {ECO:0000313\|EMBL:AAF97939.1}; Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAM18219.1} C4PFY7 [Target identity:6%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004842 [ubiquitin-protein transferase activity] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]	354	39.8	No
BRCA1-025	ENSP00000465347 ENST00000591849	K7EJW3 Show all » « Hide K7EJW3 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000465347}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005634 [nucleus] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]	96	10.9	No
BRCA1-027	ENSP00000478114 ENST00000618469	G1UI37 Show all » « Hide G1UI37 [Target identity:100%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		23	2.6	No
BRCA1-029	ENSP00000312236 ENST00000352993	P38398 Show all » « Hide P38398 [Direct mapping] Breast cancer type 1 susceptibility protein A0A024R1Z8 [Target identity:100%; Query identity:100%] Breast cancer 1, early onset, isoform CRA_b {ECO:0000313\|EMBL:EAW60938.1} K7EPC7 [Target identity:49%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|Ensembl:ENSP00000467329} Q7KYU6 [Target identity:32%; Query identity:100%] Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAB08105.1} K4JXS7 [Target identity:10%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AFU88804.1} A0A068BDV0 [Target identity:4%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83578.1} Q9UE29 [Target identity:4%; Query identity:100%] BRCA1 protein {ECO:0000313\|EMBL:CAA70003.1} A0A068BDU7 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83573.1} A0A068BI53 [Target identity:3%; Query identity:100%] Truncated breast and ovarian cancer susceptibility protein 1 {ECO:0000313\|EMBL:AIC83574.1} C4PFY7 [Target identity:3%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:ACR33809.1} G1UI37 [Target identity:3%; Query identity:100%] Breast cancer type 1 susceptibility protein {ECO:0000313\|EMBL:BAK64160.1} Q92897 [Target identity:3%; Query identity:100%] BRCA1 {ECO:0000313\|EMBL:AAB40910.1}; BRCA1 protein {ECO:0000313\|EMBL:AAC50330.1} Q9NQR3 [Target identity:3%; Query identity:100%] BRCAI {ECO:0000313\|EMBL:AAF97939.1}; Breast and ovarian cancer susceptibility protein {ECO:0000313\|EMBL:AAM18219.1}	Show » « Hide Phobius predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000151 [ubiquitin ligase complex] GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006301 [postreplication repair] GO:0006302 [double-strand break repair] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006359 [regulation of transcription from RNA polymerase III promoter] GO:0006633 [fatty acid biosynthetic process] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007059 [chromosome segregation] GO:0008270 [zinc ion binding] GO:0008274 [gamma-tubulin ring complex] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010212 [response to ionizing radiation] GO:0010575 [positive regulation vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0015631 [tubulin binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030529 [ribonucleoprotein complex] GO:0031398 [positive regulation of protein ubiquitination] GO:0031436 [BRCA1-BARD1 complex] GO:0031572 [G2 DNA damage checkpoint] GO:0031625 [ubiquitin protein ligase binding] GO:0035066 [positive regulation of histone acetylation] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043234 [protein complex] GO:0043627 [response to estrogen] GO:0044212 [transcription regulatory region DNA binding] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045766 [positive regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046600 [negative regulation of centriole replication] GO:0046872 [metal ion binding] GO:0050681 [androgen receptor binding] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051865 [protein autoubiquitination] GO:0070512 [positive regulation of histone H4-K20 methylation] GO:0070531 [BRCA1-A complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0071356 [cellular response to tumor necrosis factor] GO:0071681 [cellular response to indole-3-methanol] GO:0085020 [protein K6-linked ubiquitination] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2000378 [negative regulation of reactive oxygen species metabolic process] GO:2000617 [positive regulation of histone H3-K9 acetylation] GO:2000620 [positive regulation of histone H4-K16 acetylation]	721	80.6	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx