SPPL2B

GENE INFORMATION

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Gene name

SPPL2B (HGNC Symbol)

Synonyms

IMP4, KIAA1532, PSL1

Description

Signal peptide peptidase like 2B (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

2328615 - 2354806

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005206 (version 78.38)

Entrez gene

56928

UniProt

Q8TCT7 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TCT7

Antibodypedia

SPPL2B antibodies
 

PROTEIN VIEW

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SPPL2B-002
 
SPPL2B-004
 
SPPL2B-005
 
SPPL2B-013
 
SPPL2B-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPPL2B-002 ENSP00000478298
ENST00000613503
Q8TCT7
Show all »
Show » Show » 592 64.6 Yes 9
SPPL2B-004 ENSP00000482362
ENST00000614794
Show » Show » 291 32.5 No 4
SPPL2B-005 ENSP00000480813
ENST00000618220
Q8TCT7
Show all »
Show » Show » 319 35.3 Yes 4
SPPL2B-013 ENSP00000478510
ENST00000610743
Q8TCT7
Show all »
Show » Show » 511 56.4 Yes 9
SPPL2B-014 ENSP00000477658
ENST00000612623
Show » Show » 166 18.7 No 4